Esomeprazole+levosulpiride
About Esomeprazole+levosulpiride
Levosulpiride+esomeprazole is used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn.
Levosulpiride+esomeprazole contains Esomeprazole and Levosulpiride. Esomeprazole works by preventing the production of stomach acid. Levosulpiride works by increasing the stomach and intestinal movement and preventing the backflow of food and acid into the mouth.
In some cases, you may experience certain common side effects such as headache, abdominal pain, constipation, diarrhoea, flatulence, nausea and vomiting. You are advised to talk to your doctor if you experience these side effects persistently.
Before taking this medicine, you should tell your doctor if you are allergic to any of its components. Consult your doctor if you are pregnant or breastfeeding. Levosulpiride+esomeprazole should not be given to children as safety has not been established.
Uses of Esomeprazole+levosulpiride
Medicinal Benefits
- Levosulpiride+esomeprazole belongs to a group of medicines called gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD).
- Esomeprazole (proton pump inhibitor) works by blocking the action of an enzyme called the gastric proton pump, which is responsible for the production of acid.
- Levosulpiride (prokinetic agent) works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth.
- Levosulpiride+esomeprazole helps in preventing acid reflux, thereby providing relief from acidity and heartburn.
Directions for Use
- Levosulpiride+esomeprazole should be taken 1 hour before a meal, preferably in the morning.
- It is usually taken once daily or as prescribed by your doctor.
- Swallow Levosulpiride+esomeprazole as a whole with a glass of water.
- Do not crush, break, or open it.
Storage
Side Effects of Esomeprazole+levosulpiride
- Headache
- Abdominal pain
- Flushing
- Dry mouth
- Constipation
- Diarrhea
- Flatulence
- Nausea
- Vomiting
Medicines Containing this Salt
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Drug Warnings
- Do not take Levosulpiride+esomeprazole if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment.
- Inform your doctor before taking Levosulpiride+esomeprazole if you have severe liver or kidney problems; if you are due to have a Chromogranin A test; if you experience unexplained weight loss, stomach pain, indigestion, vomiting food or blood, or if you pass black stools.
- On long-term treatment, Levosulpiride+esomeprazole may increase the risk of bone fractures.
- Do not take Levosulpiride+esomeprazole if you are pregnant or breastfeeding.
- Levosulpiride+esomeprazole may cause dizziness and drowsiness, so drive only if you are alert.
- Levosulpiride+esomeprazole should not be given to children as safety has not been established.
- Avoid consuming alcohol along with Levosulpiride+esomeprazole as it could lead to increased drowsiness and can elevate the production of stomach acid.
Drug Interactions
Drug-Drug Interactions: Levosulpiride+esomeprazole may interact with painkillers (aspirin, naproxen), anti-HIV (atazanavir), blood thinner (clopidogrel, warfarin, cilostazol), anti-fungal (ketoconazole, itraconazole, voriconazole), anti-cancer (erlotinib, methotrexate), anti-depressant (citalopram, imipramine, clomipramine, duloxetine), anti-anxiety (diazepam), anti-convulsant (phenytoin), gastroprokinetic agent (cisapride), a drug used to treat heart problems (digoxin), immunosuppressant (tacrolimus), anti-tuberculosis (rifampicin).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interaction: Inform your doctor if you have epilepsy, mania, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, or hypomagnesemia (low levels of magnesium).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAvoid consumption of alcohol while taking Levosulpiride+esomeprazole. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn.
Pregnancy
unsafeLevosulpiride+esomeprazole should not be taken if you are pregnant. Consult your doctor before taking Levosulpiride+esomeprazole if you are pregnant.
Breast Feeding
unsafeLevosulpiride+esomeprazole may pass into breast milk. Consult your doctor before taking Levosulpiride+esomeprazole if you are breastfeeding.
Driving
cautionLevosulpiride+esomeprazole may cause dizziness, drowsiness and blurred vision. Do not drive or operate machinery unless you are alert.
Liver
unsafeLevosulpiride+esomeprazole should not be used in patients with hepatic impairment. Consult your doctor before taking Levosulpiride+esomeprazole if you have a liver impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. Consult your doctor before taking Levosulpiride+esomeprazole if you have kidney impairment or any concerns regarding this.
Children
unsafeLevosulpiride+esomeprazole should not be given to children as the safety and effectiveness were not established.
Habit Forming
Diet & Lifestyle Advise
- Eat smaller meals more often.
- Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
- Maintain a healthy weight through regular exercise.
- Avoid lying down after eating, as it causes acid reflux.
- Avoid tight-fitting clothes as they might increase the pressure on the abdomen, leading to acid reflux.
- Practice relaxation techniques and avoid stress by doing yoga or meditation.
- Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda.
- Avoid sitting continuously, as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.
Special Advise
- Levosulpiride+esomeprazole may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Levosulpiride+esomeprazole.
- Inform your doctor before taking Levosulpiride+esomeprazole if you are due to have a Chromogranin A test.
Patients Concern
Disease/Condition Glossary
Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth and difficulty swallowing.
FAQs
Levosulpiride+esomeprazole is used to treat gastro-oesophageal reflux disease (GERD). Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (oesophagus); this causes acidity, pain and heartburn.
Levosulpiride+esomeprazole is a combination of two drugs, namely: Esomeprazole and Levosulpiride. Esomeprazole works by blocking the action of an enzyme called gastric proton pump, which is responsible for the production of acid. Levosulpiride works by increasing the stomach and intestinal movement and pressure of the inferior oesophageal (food pipe) sphincter, thereby preventing the backflow of food and acid into the mouth. Together, Levosulpiride+esomeprazole helps in preventing acid reflux, thereby providing relief from acidity.
Diarrhoea might be a side effect of Levosulpiride+esomeprazole. Drink enough fluids and eat non-spicy food if you experience diarrhoea. If you find blood in your stools (tarry stools) or if you experience severe diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.
Do not take Levosulpiride+esomeprazole with nelfinavir (a drug used to treat HIV infections). Consult your doctor before taking Levosulpiride+esomeprazole with other medications to avoid potential side effects.
Levosulpiride+esomeprazole contains esomeprazole, which might increase the risk of fracture in the wrist, hip or spine. This mainly occurs in people taking Levosulpiride+esomeprazole for longer durations. Inform your doctor if you have osteoporosis or if you are taking corticosteroids; your doctor may prescribe calcium and vitamin D supplements.
Levosulpiride+esomeprazole may cause changes in blood tests for checking liver functioning. Inform the person doing the tests that you are taking Levosulpiride+esomeprazole.
Dry mouth could be a side effect of Levosulpiride+esomeprazole. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy may help stimulate saliva and thereby prevent mouth dryness.
Levosulpiride+esomeprazole works by relieving the symptoms such as heartburn, stomach pain, or irritation. It also neutralises the acid production in the stomach to prevent discomfort.
Levosulpiride+esomeprazole contains Esomeprazole and Levosulpiride.
The usual recommendation is to take it one hour before the meal, preferably in the morning.
Yes, Levosulpiride+esomeprazole may cause dizziness and drowsiness, so drive or operate machinery only if you are alert.
Yes, it can help to ease stomach pain.
Store Levosulpiride+esomeprazole according to the instructions on the leaflet, away from sunlight, at a temperature not exceeding 25°C. Dispose of unused medicine. Keep it out of reach of pets and children.
Levosulpiride+esomeprazole is usually taken in the morning, one hour before the food, or as directed by the physician.
Levosulpiride+esomeprazole is contraindicated for use if you are allergic to any of its contents, if you are taking nelfinavir (anti-HIV), if you have a gastrointestinal haemorrhage, mechanical obstruction or perforation, epilepsy, mania, porphyria, or cardiac impairment. It is also contraindicated for use in pregnant and breastfeeding women.
Levosulpiride+esomeprazole might increase the risk of wrist, hip or spine fracture. This mainly occurs in individuals taking Levosulpiride+esomeprazole for extended periods.
Common side effects of Levosulpiride+esomeprazole may include headache, abdominal pain, constipation, diarrhea, flatulence, nausea and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Levosulpiride+esomeprazole should not be given to children as safety and effectiveness have not been established.
