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About METRONIDAZOLE+NORFLOXACIN

METRONIDAZOLE+NORFLOXACIN is a combination drug containing antibacterial and anti-amoebic medication, primarily used to treat dysentery and diarrhea caused due to amoeba. In addition, it is also used to treat infections caused due to microbes. Amoebic dysentery can be caused due to Entamoeba histolyticaGiardia lamblia or Clostridium difficile.

METRONIDAZOLE+NORFLOXACIN is a combination medicine that contains Norfloxacin and Metronidazole. Norfloxacin prevents the division of bacterial cells. It also inhibits the repairing of bacterial cells. Metronidazole kills parasites and anaerobic bacteria that are responsible for causing infections. It works by damaging their DNA. Both are bactericidal (kills the bacteria) in nature, and collectively they help treat the disease effectively.

Take METRONIDAZOLE+NORFLOXACIN in the dose and duration as advised by your doctor. It is advised to take it with food at a fixed time to achieve maximum effect. In some cases, you may experience nausea, vomiting, upset stomach, loss of appetite, dry mouth and metallic taste. Metronidazole can also cause headaches, dizziness, drowsiness and confusion. Most of these side effects of METRONIDAZOLE+NORFLOXACIN do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. If you experience any allergic reaction symptoms such as rashes, itching, swelling, shortness of breath, etc., please consult your doctor immediately.

It is not advisable to stop taking METRONIDAZOLE+NORFLOXACIN suddenly to avoid unpleasant side effects. The full course prescribed by the doctor should be completed. Inform your doctor if you have any lung disease, epilepsy, sleeping disorder or difficulty sleeping (sleep apnoea), severe liver disease or problem with alcohol or other prescription recreational drugs. METRONIDAZOLE+NORFLOXACIN should not be used by pregnant women (especially during the first trimester), breastfeeding mothers and patients with liver diseases, low blood white cells (leukopenia), or gastro intestine diseases (like Crohn's disease, Inflammatory bowel disease, etc.). Do not drive or operate heavy machinery, as it can lower your mental alertness and cause dizziness.

Uses of METRONIDAZOLE+NORFLOXACIN

Diarrhea, Dysentry, Intestinal infection

Medicinal Benefits

METRONIDAZOLE+NORFLOXACIN is a combination medicine that consists of Norfloxacin and Metronidazole. Norfloxacin prevents the division of bacterial cells. It also inhibits the repairing of bacterial cells. Both these actions lead to the killing of the bacteria. Metronidazole kills parasites and bacteria that are responsible for causing infections. It works by damaging their DNA. Both are bactericidal.

 

 

Directions for Use

Tablet: METRONIDAZOLE+NORFLOXACIN can be taken with or without food (excluding dairy products) or as prescribed by your doctor. Swallow it as a whole with water; do not crush, break or chew it. Suspension: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dropper.

Storage

Store in a cool and dry place away from sunlight

Side Effects of METRONIDAZOLE+NORFLOXACIN

  • Nausea
  • Vomiting
  • Headache
  • Dizziness
  • Upset stomach
  • Heartburn
  • Loss of appetite
  • Dry mouth
  • Metallic taste

In-Depth Precautions and Warning

Drug Warnings

If you are allergic to norfloxacin, metronidazole or any other antibacterial or anti-amoebic agents, please inform your doctor to avoid unwanted side effects like swallowing or breathing problems, and swelling of your lips, face, throat or tongue. Taking METRONIDAZOLE+NORFLOXACIN may increase the chances of developing tendinitis (swelling of a tissue that joins a bone to a muscle) or a tendon rupture. Dairy products should be avoided along with METRONIDAZOLE+NORFLOXACIN. And also, exposure to sunlight should be avoided while taking METRONIDAZOLE+NORFLOXACIN as it may cause increased phototoxicity or photosensitivity. Patients with an irregular heartbeat (QT prolongation) should tell their doctor before taking METRONIDAZOLE+NORFLOXACIN. METRONIDAZOLE+NORFLOXACIN should not be given to the pregnant mother (during the first trimester) and in nursing mothers as it passes into the breast milk. Please inform your doctor before taking METRONIDAZOLE+NORFLOXACIN if you have a history of problems with your liver, blood, low white blood cell count (leukopenia), and nervous system (convulsions). Do not drink alcohol with METRONIDAZOLE+NORFLOXACIN as it may cause flushing and drowsiness, which can alter your mental alertness.

Drug Interactions

Drug-Drug Interaction: This medicine may have an interaction with other antibiotics (sparfloxacin, azithromycin, sulfamethoxazole, trimethoprim, metronidazole, nitrofurantoin, erythromycin), calcium supplements (calcium/vitamin D), pain killers (ibuprofen or diclofenac), anti-asthma (theophylline), anti-diabetic (glibenclamide), anti-gout (probenecid), anti-cancer (busulfan, fluorouracil, mycophenolate), antidepressant (lithium), antiepileptic (phenobarbital, phenytoin) and blood thinner (warfarin).

Drug-Food Interaction: METRONIDAZOLE+NORFLOXACIN interacts with dairy products (like milk or yogurt) or calcium-fortified juices alone, alcohol.

Drug-Disease Interaction: Inform your doctor if you have or have ever had a liver, kidney or heart problem or lung transplant, a joint or tendon disorder (rheumatoid arthritis), seizures (fits), low white blood cell count (leukopenia), epilepsy, muscle problems (myasthenia gravis), heart rhythm disorder (arrhythmia), seizures (fits), alcoholism, cancer, electrolyte imbalance (low potassium or magnesium level), colitis (inflammation of the intestine), porphyria (rare genetic blood disorder) and neuro-related diseases.

Drug-Drug Interactions Checker List:

  • SPARFLOXACIN
  • AZITHROMYCIN
  • SULFAMETHOXAZOLE
  • TRIMETHOPRIM
  • ERYTHROMYCIN
  • NITROFURANTOIN
  • CALCIUM
  • IBUPROFEN
  • DICLOFENAC
  • THEOPHYLLINE
  • GLIBENCLAMIDE
  • PROBENECID
  • BUSULFAN
  • FLUOROURACIL
  • MYCOPHENOLATE MOFETIL
  • LITHIUM
  • PHENOBARBITAL
  • PHENYTOIN
  • WARFARIN
  • Safety Advice

    • Safety Warning

      Alcohol

      caution

      Alcohol should not be consumed while taking METRONIDAZOLE+NORFLOXACIN as it may cause unpleasant side effects like flushing, lightheadedness, dizziness and drowsiness.

    • Safety Warning

      Pregnancy

      unsafe

      METRONIDAZOLE+NORFLOXACIN should not be taken if you are pregnant or planning pregnancy. If you become pregnant while taking METRONIDAZOLE+NORFLOXACIN, stop taking the medication and contact your doctor immediately. Metronidazole should not be given in the first trimester of pregnancy as it may harm the fetus.

    • Safety Warning

      Breast Feeding

      caution

      METRONIDAZOLE+NORFLOXACIN is not recommended for use in breastfeeding as it may pass into breast milk and may harm your infant. Please consult your doctor before taking this medicine.

    • Safety Warning

      Driving

      caution

      METRONIDAZOLE+NORFLOXACIN can cause dizziness in some patients. If you feel dizzy after taking this medicine, avoid driving or operating machines.

    • Safety Warning

      Liver

      caution

      METRONIDAZOLE+NORFLOXACIN to be taken with caution, especially if you have a pre-existing or a history of liver disease. Your doctor may adjust the dose if required based on your condition.

    • Safety Warning

      Kidney

      caution

      METRONIDAZOLE+NORFLOXACIN to be taken with caution, especially if you have a pre-existing or a history of kidney disease. Your doctor may adjust the dose if required based on your condition.

    • Safety Warning

      Children

      caution

      METRONIDAZOLE+NORFLOXACIN is recommended for children with diarrhea, a stomach infection, amoebiasis, abdominal infection, and intestinal infection. Use it as prescribed by your doctor.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Do not drink or eat a lot of caffeine-containing products such as coffee, tea, energy drinks, cola or chocolate. METRONIDAZOLE+NORFLOXACIN may increase nervousness, sleeplessness and anxiety caused by caffeine.
    • Probiotics should be taken after taking the full course of METRONIDAZOLE+NORFLOXACIN to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhea. Certain fermented foods like yogurt, cheese, sauerkraut, kombucha and kimchi can help restore the intestine's good bacteria. 
    • Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after antibiotics. Whole grains like whole-grain bread and brown rice should be included in your diet. Make sure you drink plenty of water or other fluids every day while you are taking METRONIDAZOLE+NORFLOXACIN.
    • Avoid alcoholic beverages with METRONIDAZOLE+NORFLOXACIN as they can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the METRONIDAZOLE+NORFLOXACIN in fighting off infections.

    Special Advise

    • You should consult a doctor if you have symptoms associated with dehydration, like dry mouth, excessive thirst, wrinkled skin, little or no urination, dizziness and lightheadedness.
    • METRONIDAZOLE+NORFLOXACIN may cause changes in liver function tests and prothrombin time (time taken for blood clotting). Inform the person doing the tests that you are taking METRONIDAZOLE+NORFLOXACIN.

    Patients Concern

    Disease/Condition Glossary

    • Diarrhea: It is the increase in bowel movement leading to increased and loose motions. 
    • Dysentery: It is inflammation of the intestine, particularly the colon, caused by bacteria.

    FAQs

    How does METRONIDAZOLE+NORFLOXACIN work?

    METRONIDAZOLE+NORFLOXACIN contains antibiotics that work by preventing the division of bacterial cells. It also inhibits the repairing of bacterial cells. Both these actions lead to the killing of the bacteria and hence treating the infection.

    Can I take alcohol along with METRONIDAZOLE+NORFLOXACIN?

    It is not advised to take alcohol with METRONIDAZOLE+NORFLOXACIN. Taking alcohol while taking METRONIDAZOLE+NORFLOXACIN can cause serious side effects such as headaches, feeling or being sick, pain in the stomach, hot flushes, a fast or irregular heartbeat, dizziness, drowsiness, etc.

    Can METRONIDAZOLE+NORFLOXACIN cause dry mouth?

    Yes, METRONIDAZOLE+NORFLOXACIN is known to cause dry mouth, especially when you start taking METRONIDAZOLE+NORFLOXACIN. If you feel excessively thirsty, do frequent mouth rinses, and increase fluid intake.

    Why exposure to sunlight is avoided while taking METRONIDAZOLE+NORFLOXACIN?

    METRONIDAZOLE+NORFLOXACIN makes your skin sensitive to sunlight, known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In case of emergency, you should always wear sunscreen before going out.

    Does intake of METRONIDAZOLE+NORFLOXACIN cause dry mouth?

    Yes, intake of METRONIDAZOLE+NORFLOXACIN may cause dry mouth, and you might feel thirsty frequently. Try to drink plenty of fluids (water with electrolytes) and probiotics. You may also have a dry lip for which you can use lip balm.

    In which disease condition should I avoid taking METRONIDAZOLE+NORFLOXACIN?

    Avoid intake of METRONIDAZOLE+NORFLOXACIN if you have a history of problems with your liver, blood or nervous system (convulsions or fits) or low white blood cell count (leukopenia).

    Available Medicines for

    METRONIDAZOLE+NORFLOXACIN