About NEBIVOLOL+INDAPAMIDE
NEBIVOLOL+INDAPAMIDE is a combination drug containing antihypertensive medication, primarily used to treat high blood pressure (hypertension). Hypertension (High blood pressure) is a condition in which the force exerted by the blood against the artery walls becomes so high that it causes health problems, such as heart disease. It is also used to reduce strokes and chest pain (angina) caused by the arteries' blockage. In addition to this, NEBIVOLOL+INDAPAMIDE is also used to treat preterm labour.
NEBIVOLOL+INDAPAMIDE contains Nebivolol and Indapamide. Nebivolol is a beta-blocker; that relaxes and widens the blood vessels making it easier for the heart to pump blood to all parts of the body. This helps in decreasing the blood pressure and the risk of having a heart attack or stroke. Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure.
Take NEBIVOLOL+INDAPAMIDE as prescribed by your doctor. You are advised to take NEBIVOLOL+INDAPAMIDE for as long as your doctor has prescribed it for you, depending upon your medical condition. You may experience nausea, constipation, fatigue, headache, stomach pain, diarrhoea, indigestion, weakness, dizziness, cough, peripheral oedema (swelling in feet and hands), nervousness, hypertonia (increased muscle tone) in some cases. Most of these side effects of NEBIVOLOL+INDAPAMIDE do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
Try not to stop taking this medicine of your own as it may suddenly increase blood pressure, chest pain or may cause a heart attack. Let your doctor know if you have any liver or heart problems, are pregnant or breastfeeding. You should monitor your blood pressure regularly to be sure that the NEBIVOLOL+INDAPAMIDE is working efficiently. And also, a healthy diet, regular exercise is necessary to keep blood pressure under control. Do not eat grapefruit or drink grapefruit juice while you're taking nifedipine. It can make side effects worse. Even a small reduction in sodium in your diet helps improve your heart's health and reduce blood pressure. Avoid alcohol consumption while taking NEBIVOLOL+INDAPAMIDE as it might lower the blood pressure than normal.
Uses of NEBIVOLOL+INDAPAMIDE
Hypertension (high blood pressure).
Medicinal Benefits
NEBIVOLOL+INDAPAMIDE is a combination drug containing antihypertensive medication, Nebivolol, and Indapamide, primarily used to treat high blood pressure (hypertension). In addition to this, nebivolol also helps prevent increased heart rate and controls heart pumping strength, and indapamide also treats fluid retention and overload (oedema) in congestive heart failure patients. Nebivolol is a beta-blocker; that relaxes and widens the blood vessels making it easier for the heart to pump blood to all parts of the body. This helps in decreasing the blood pressure and the risk of having a heart attack or stroke. Indapamide is a thiazide diuretic that inhibits excess salt absorption in the body, resulting in increased chloride, sodium, and water excretion through urine. This diuresis process (increased urine production) and excess salts and fluid removal help lower blood pressure.
Directions for Use
Storage
Side Effects of NEBIVOLOL+INDAPAMIDE
- Nausea
- Constipation
- Fatigue
- Headache
- Stomach pain
- Diarrhoea
- Indigestion
- Weakness
- Dizziness, Infection
- Cough
- Peripheral oedema (swelling in feet and hands)
- Nervousness
In-Depth Precautions and Warning
Drug Warnings
Do not skip any doses or stop taking NEBIVOLOL+INDAPAMIDE without consulting your doctor. Avoid intake of NEBIVOLOL+INDAPAMIDE if you are allergic to any of its contents. Talk to your doctor if you have heart, kidney, or liver problems. Do not take NEBIVOLOL+INDAPAMIDE if you have low blood pressure, serious circulation problems in arms and legs, very slow heartbeat, serious heart rhythm problems, recent heart failure, asthma, liver function disorder, or metabolic disorder. Avoid taking NEBIVOLOL+INDAPAMIDE if you are pregnant or breast-feeding, and talk to your doctor. Avoid alcohol consumption while taking NEBIVOLOL+INDAPAMIDE as it might lower the blood pressure than normal. NEBIVOLOL+INDAPAMIDE is not recommended for children below the age of 18 years as the efficacy and safety have not been established. Regular monitoring of blood pressure, electrolyte levels, and kidney functioning is advised while taking NEBIVOLOL+INDAPAMIDE.
Drug Interactions
Drug-Drug Interaction: NEBIVOLOL+INDAPAMIDE may have interaction with diuretic medications (hydrochlorothiazide, furosemide), anti-hypertensive drugs (chlorthalidone, ramipril, metoprolol, amlodipine), drugs treating mental illness (alprazolam, amisulpride), painkillers (ibuprofen, naproxen), anti-depressants (lithium), diabetic drugs (Insulin glargine, metformin), drugs treating stomach acid (esomeprazole), fits medicine (clonazepam), corticosteroids (prednisone), drugs treating impotence (sildenafil). Maintain a gap of two hours between NEBIVOLOL+INDAPAMIDE and multivitamins and minerals as they might decrease the effects of NEBIVOLOL+INDAPAMIDE.
Drug-Food Interaction: Maintain low salt and low-fat diet while taking NEBIVOLOL+INDAPAMIDE. Avoid alcohol consumption while taking NEBIVOLOL+INDAPAMIDE as it might lower the blood pressure than normal. Avoid foods containing high cholesterol while taking NEBIVOLOL+INDAPAMIDE.
Drug-Disease Interaction: NEBIVOLOL+INDAPAMIDE may have interactions with diabetes, hypersensitivity, liver impairment, high cholesterol, hyperthyroidism, psoriasis, kidney impairment, asthma, heart problems, such as bradyarrhythmia, cardiogenic shock, low blood pressure, fast heart rate, ischemic heart disease, and congestive heart failure, and low potassium levels (hypokalemia).
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol may lower your blood pressure. It would help if you avoided or limit consuming alcohol whilst taking this medicine
Pregnancy
cautionIt is not recommended to take NEBIVOLOL+INDAPAMIDE while pregnant as it is a pregnancy category C drug, and it is unknown whether it will harm the baby. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe you NEBIVOLOL+INDAPAMIDE only if the benefits outweigh the risks.
Breast Feeding
cautionThere are limited studies on how NEBIVOLOL+INDAPAMIDE affects the breastfed infants. However, Indapamide in NEBIVOLOL+INDAPAMIDE may pass into the breast milk during breastfeeding. Please consult your doctor before using NEBIVOLOL+INDAPAMIDE if you are a lactating mother.
Driving
cautionNEBIVOLOL+INDAPAMIDE may cause side effects due to lowering of the blood pressure such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.
Liver
cautionDose adjustment may be needed. NEBIVOLOL+INDAPAMIDE should be used with caution in patients with liver impairment/liver disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Kidney
cautionDose adjustment may be needed. NEBIVOLOL+INDAPAMIDE should be used with caution in patients with kidney impairment/kidney disease. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
unsafeNEBIVOLOL+INDAPAMIDE is not recommended for use in people below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Keep your weight under control with a body mass index (BMI) between 19.5 and 24.9.
- Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
- Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
- If you are taking alcohol, use only one serving for women and two servings for men.
- Quit smoking to lower the risk of heart diseases.
- Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
- Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
- Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil that help in lowering your elevated blood pressure.
Special Advise
- Monitor your blood pressure regularly and seek medical advice if you notice any drastic fluctuations.
- Let your doctor know if you are advised for any blood examinations as, diuretics like Indapamide can cause changes in the laboratory parameters like low potassium levels in the blood, low sodium in the blood, low blood pressure, increase in uric acid, increase in blood glucose levels in diabetic patients, increase in calcium levels in the blood, and increase in the liver enzyme levels.
- Athletes should be aware that Indapamide in NEBIVOLOL+INDAPAMIDE gives a positive reaction in doping tests.
Patients Concern
Disease/Condition Glossary
Hypertension: It is a chronic condition when blood pressure is too high. Blood pressure is defined as the amount of blood pumped by the heart and the amount of resistance exerted by the arteries against the blood flow. If the heart pumps more blood, then arteries become narrower, and in turn, blood pressure becomes high. If blood pressure becomes uncontrolled, it may lead to serious heart diseases, including stroke and heart attack. Additionally, high blood pressure can also cause brain damage (stroke) and kidney failure. Blood pressure is expressed as systolic and diastolic pressures. Systolic blood pressure represents the contraction and relaxation of the heart. Diastolic pressure is exerted in the blood vessels when the heart beats and is in the resting state. Ideal blood pressure should be between 90/60mmHg and 120/80mmHg. Hypertension is detected when systolic blood pressure is more than 140mmHg, and diastolic pressure is higher than 90mmHg. Some of the symptoms of hypertension include headache, nose bleed, vomiting, and chest pain.
