Ofloxacin+tinidazole
About Ofloxacin+tinidazole
Ofloxacin+tinidazole is a combination of medicines called 'antibiotics' primarily used to treat various infections caused by bacteria & protozoans. Ofloxacin+tinidazole is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria.
Ofloxacin+tinidazole is a combination of two antibiotics: Ofloxacin and Tinidazole. Ofloxacin helps treat and prevent a wide range of bacterial infections. It is bactericidal in nature, which means it works by killing bacteria that cause infections. It inhibits the processes of bacterial cells, ultimately destroying the bacteria and thereby preventing the further spread of the infection. Ofloxacin+tinidazole is a broad-spectrum antibiotic against most Gram-negative bacteria, many Gram-positive bacteria, and some anaerobic bacteria (that live without oxygen). On the other hand, Tinidazole kills parasites and anaerobic bacteria responsible for causing infections. It works by damaging their genetic material, called DNA.
Ofloxacin+tinidazole should be taken in the dose and duration your doctor advises. It is recommended to take it with food and at a fixed time to achieve maximum effect. You may experience nausea, vomiting, stomach pain, loss of appetite, headache, and other symptoms. Most of these side effects of Ofloxacin+tinidazole do not require medical attention and typically resolve on their own over time. However, if the side effects are persistent, reach out to your doctor. Please consult your doctor immediately if you experience any allergic reaction symptoms such as rashes, itching, swelling, or shortness of breath.
Inform your doctor if you have any lung disease, muscle weakness (myasthenia gravis), a sleeping disorder or difficulty sleeping (sleep apnoea), severe liver disease, or a problem with alcohol or other prescription or recreational drugs. Inform your doctor if you plan to get pregnant, are pregnant, or are breastfeeding. Use of Ofloxacin+tinidazole is associated with an increased risk of tendinitis and tendon (tough tissue that connects muscle to bone) rupture in all ages. People taking Ofloxacin+tinidazole who are over 60 years are at high risk, especially those taking anti-allergic medicines like corticosteroid drugs. Ofloxacin+tinidazole is contraindicated in people with kidney/heart diseases and those who have had lung transplants; its use is not recommended.
Uses of Ofloxacin+tinidazole
• Treatment of Bacterial Infections: Ofloxacin+tinidazole is an antibiotic used to treat various bacterial infections, including respiratory, urinary tract, sexually transmitted infections, and skin infections.
• Management of Gastrointestinal Infections: Ofloxacin+tinidazole helps to treat gastrointestinal infections caused by bacteria, relieving symptoms and promoting recovery.
• Urinary tract Infections (UTIs): Ofloxacin+tinidazole can be used to treat urinary tract infections (UTIs) caused by susceptible bacteria.
• Preventing Infection: Ofloxacin+tinidazole can be prescribed to prevent infections in patients undergoing surgery or those with weakened immune systems.
Medicinal Benefits
Ofloxacin+tinidazole contains the antibiotics Ofloxacin and Tinidazole, which help treat and prevent a wide range of bacterial infections caused by Gram-negative bacteria, Gram-positive bacteria, and some anaerobic bacteria (that live without oxygen). It is bactericidal and works by killing bacteria that cause infections by preventing the formation of their cell walls, which are required for living. It also inhibits the repair of bacterial cells. Altogether, it kills the bacteria. Ofloxacin+tinidazole has the advantage of good penetration in most deep tissues and body fluids. Hence, it is also suitable for treating deep tissue and bone bacterial infections.
Directions for Use
- Ofloxacin+tinidazole can be taken with or without food (excluding dairy products).
- Follow your doctor's instructions on the dosage and timing of this medication.
- Swallow Ofloxacin+tinidazole as a whole with a glass of water.
- Do not crush, break, or chew it.
Storage
Side Effects of Ofloxacin+tinidazole
- Nausea
- Vomiting
- Headache
- Headache
- Metallic taste
- Stomach pain
- Loss of appetite
- Dryness in the mouth
Drug Warnings
Do not take Ofloxacin+tinidazole if you are allergic or have had a severe reaction to Ofloxacin or other quinolone or fluoroquinolone antibiotics such as Delafloxacin, Gemifloxacin, Levofloxacin, Moxifloxacin, and Ciprofloxacin. Taking Ofloxacin+tinidazole may increase the chances of developing tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or having a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle). Inform your doctor if you have or have ever had a kidney, heart, or lung transplant, kidney disease, a joint or tendon disorder such as rheumatoid arthritis (an autoimmune condition of joints causing pain, swelling, and loss of function), seizures (fits), epilepsy or if you participate in regular physical activity. Taking Ofloxacin+tinidazole may worsen muscle weakness in people with myasthenia gravis (a nervous system disorder that causes muscle weakness) and cause severe difficulty breathing or death. Dairy products should be avoided along with Ofloxacin+tinidazole. Additionally, exposure to sunlight should be avoided while taking Ofloxacin+tinidazole, as it may increase phototoxicity or photosensitivity. Patients with epilepsy and irregular heartbeat (QT prolongation) should tell their doctor before taking Ofloxacin+tinidazole.
Drug Interactions
Drug-Drug Interaction: This medicine may have an interaction with blood thinners (aspirin, warfarin), antidepressants and antipsychotics (clozapine, olanzapine), caffeine, insulin or other anti-diabetic medications (chlorpropamide, glimepiride, glipizide, glyburide, metformin, tolazamide, and tolbutamide), medications for regulating irregular heartbeat (amiodarone, disopyramide, procainamide, quinidine), pain killers (ibuprofen, naproxen). Take Ofloxacin+tinidazole either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product containing calcium, magnesium, aluminium, iron, zinc, an antiulcer agent (such as sucralfate), or an anti-HIV drug (such as didanosine).
Drug-Food Interaction: Ofloxacin+tinidazole interacts with dairy products (milk or yoghurt) or calcium-fortified juices alone.
Drug-Disease Interaction: Inform your doctor if you have or have ever had tendon rupture, musculoskeletal problem (myopathy, rhabdomyolysis), kidney/heart/lung transplant, low blood potassium (hypokalemia), kidney disease, rheumatoid arthritis, seizures (fits), epilepsy or any other neurological disorder if you participate in regular physical activity before starting Ofloxacin+tinidazole.
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeAlcohol is not known to cause any unpleasant side effects if taken along with Ofloxacin+tinidazole. But the intake of alcohol may damage your liver. So, consuming alcohol should be avoided with Ofloxacin+tinidazole.
Pregnancy
consult your doctorOfloxacin+tinidazole is a pregnancy Category C medicine. It is not known whether Ofloxacin+tinidazole will affect pregnancy. Hence, the intake of Ofloxacin+tinidazole should be avoided if you are pregnant or planning to become pregnant, as it may harm your foetus. Please consult your doctor.
Breast Feeding
unsafeOfloxacin+tinidazole is excreted in human milk. But the amount of Ofloxacin+tinidazole absorbed by the nursing infant is unknown. So, it may be unsafe to be used while breastfeeding. Please consult your doctor.
Driving
unsafeOfloxacin+tinidazole can affect alertness and coordination. So, driving vehicles and operating machinery which requires concentration should be avoided.
Liver
cautionOfloxacin+tinidazole to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may need to adjust the dose if you experience symptoms such as nausea, vomiting, loss of appetite, dark-coloured urine, or yellow discolouration of the skin or eyes.
Kidney
cautionOfloxacin+tinidazole to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.
Children
unsafeOfloxacin+tinidazole is not recommended for use in children and adolescents below 18 years of age.
Habit Forming
Diet & Lifestyle Advise
- Avoid consuming many caffeine-containing products, such as coffee, tea, energy drinks, cola, and chocolate. Ofloxacin+tinidazole may increase nervousness, sleeplessness and anxiety caused by caffeine.
- Probiotics should be taken after taking the full course of Ofloxacin+tinidazole to restore some healthy bacteria in the intestines that may have been killed. Taking probiotics after antibiotic treatment can reduce the risk of antibiotic-associated diarrhoea. Certain fermented foods, such as yoghurt, cheese, sauerkraut, kombucha, and kimchi, can help restore the intestine's good bacteria.
- Include more fibre-enriched food in your diet, as it can be easily digested by gut bacteria, which helps stimulate their growth. Thus, fibre-rich foods may help restore healthy gut bacteria after a course of antibiotics. Whole grains, such as whole-grain bread and brown rice, should be included in your diet. Make sure you drink plenty of water or other fluids daily while taking Ofloxacin+tinidazole.
- Avoid alcoholic consumption with Ofloxacin+tinidazole as it can make you dehydrated and may affect your sleep. This can make it harder for your body to aid the Ofloxacin+tinidazole in fighting off infections.
Special Advise
- Tendon damage (especially to the Achilles tendon) can occur within 48 hours of starting Ofloxacin+tinidazole treatment, so at the first sign of tendinitis (like painful swelling or inflammation), immediately stop taking Ofloxacin+tinidazole and consult a doctor. The affected limbs should be appropriately treated (immobilisation).
- In rare cases, prolonged use of Ofloxacin+tinidazole may increase blood sugar levels, requiring regular blood sugar monitoring.
- Ofloxacin+tinidazole may cause confusion and dizziness, affecting the central nervous system. If you experience any of these symptoms, immediately stop taking Ofloxacin+tinidazole and consult a doctor.
Patients Concern
Disease/Condition Glossary
A bacterial infection is a condition in which harmful bacteria enter, multiply, and infect our bodies. It can target any body part and multiple parts very quickly. When you get infected with bacteria, you can experience generalised symptoms like fevers, chills, and fatigue. Bacteria are of various forms, commonly spherical, rod-shaped, and spiral-shaped. Bacterial infections range from minor illnesses, such as sore throats and ear infections, to severe brain infections, including meningitis and encephalitis. A few harmful bacteria that cause infections include Streptococcus, Staphylococcus, and E. coli. Anyone can contract a bacterial infection. Individuals with weakened immune systems or those taking immunosuppressive medications are more susceptible to bacterial infections.
Pneumonia: In this type of infection, there is inflammation of the air sacs in one or both lungs. Various organisms, including bacteria, viruses, and fungi, can cause it.
Endocarditis: It is the infection of the inner lining of the heart chambers and heart valves. It can occur when microorganisms, such as bacteria, fungi, or other germs from other body parts, like the mouth, spread through the bloodstream and attach to damaged areas in the heart.
Septic arthritis: It is also known as joint infection or infectious arthritis. Joint inflammation is due to an infectious agent's invasion of a joint.
Osteomyelitis is an infection of the bone caused by Staphylococcus bacteria, which can be found in the nose or skin of healthy individuals.
Meningitis is an inflammation of the meninges, which are the membranes that cover the brain and spinal cord. It occurs due to infection, which can be caused by bacteria or viruses.
Dysentery is an inflammation of the intestine, particularly the colon, caused by the bacterium Shigella.
Diarrhoea: It is a medical condition in which a person faces loose, watery stools loose or a frequent need to have a bowel movement.
FAQs
Ofloxacin+tinidazole is used to treat various infections caused by bacteria and protozoans. It is used to treat a wide variety of infections caused by susceptible Gram-positive organisms, Gram-negative organisms, anaerobes, and protozoa. Examples of infection caused by protozoa include dysentery (inflammation of the colon) and malaria.
Not recommended. A patient with a transplanted kidney might be taking an immunosuppressive drug like cyclosporin, which is contraindicated with Ofloxacin+tinidazole failing to respond to the efficacy of the immunosuppressant drug. There are chances of rejection of the transplanted kidney in the patient, and, hence, it is not recommended to take Ofloxacin+tinidazole without a doctor's consultation.
Do not consume alcohol or alcohol-based products while taking Ofloxacin+tinidazole and for at least 3 days after your treatment commences. You may experience unpleasant side effects, such as a fast heartbeat, nausea, vomiting, sweating, and tingling under your skin.
Yes, after taking Ofloxacin+tinidazole, you may have diarrhoea. Ofloxacin+tinidazole is an antibiotic that kills or prevents bacterial growth, so some good intestinal bacteria that aid digestion might also get killed. Therefore, drink plenty of fluids and take probiotics to prevent excessive fluid loss from the body (dehydration).
It is advised not to take Ofloxacin+tinidazole with dairy products, as it may affect the absorption and efficacy of Ofloxacin+tinidazole. However, you can take it with a meal that includes these foods or drinks.
Ofloxacin+tinidazole can make your skin sensitive to sunlight, a condition known as photosensitivity. So, prolonged exposure to sunlight or ultraviolet light should be avoided. In the event of an emergency, always wear sunscreen before going outdoors.
If you miss a dose of Ofloxacin+tinidazole, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
Take Ofloxacin+tinidazole either 2 hours before or 2 hours after taking an antacid, multivitamin, or other product that has calcium/magnesium/aluminium/iron/zinc, antiulcer agent (sucralfate) or anti-HIV drug (didanosine).
No, Ofloxacin+tinidazole should be taken as advised by the doctor in terms of dose and duration. If you take it in a dose greater than the recommended amount, it may cause unpleasant side effects. If you think your symptoms are not improving, please consult your doctor
Ofloxacin+tinidazole contains lactose, so tell your doctor if you are intolerant to some sugars.
It is advised to tell your doctor if you are already taking Warfarin before taking Ofloxacin+tinidazole as it can increase the time it takes for blood clotting.
Take Ofloxacin+tinidazole for as long as it is prescribed by your doctor. It is important to complete the full course of treatment for effective results.
Yes, Ofloxacin+tinidazole can cause dry mouth as a side effect. If you experience this, it's essential to stay hydrated by drinking plenty of water, taking regular sips throughout the day, and keeping a glass of water by your bedside at night.
You are recommended to take your doctor’s advice before taking Ofloxacin+tinidazole if you are breastfeeding, as Ofloxacin+tinidazole might enter breast milk and harm the unborn child.
Yes, a metallic taste may occur as a side effect of using Ofloxacin+tinidazole. This is usually temporary and can be managed by chewing sugar-free gum or mints, brushing your teeth after meals, and drinking plenty of water. If this side effect persists, consult your doctor.
The use of Ofloxacin+tinidazole is harmful for patients with a known allergy to ofloxacin or tinidazole. It should be avoided in patients with a history of tendinitis (inflammation of the tendons), or tendon rupture when using ofloxacin or any other medicine that belongs to the same group (quinolone group) of antimicrobial agents, and in patients with certain neurological disorders, kidney, or heart diseases.
Store the Ofloxacin+tinidazole in a cool, dry place at room temperature, away from direct light. Keep it out of reach of children.
Inform your doctor if you don't feel better after finishing the full course of treatment. Also, please inform us if your symptoms are worsening while using this Ofloxacin+tinidazole.
No, you should not stop taking Ofloxacin+tinidazole even if you feel better. Complete the full course of treatment as prescribed by your doctor. If you stop using Ofloxacin+tinidazole too early, your infection may worsen.
Ofloxacin+tinidazole may affect alertness and coordination. Therefore, do not drive until you know how this medication affects you.
The common side effects of Ofloxacin+tinidazole are nausea, vomiting, stomach pain, loss of appetite, headache, and dry mouth. If any of these side effects persist or worsen, please consult your doctor.
