PANOBINOSTAT belongs to the group of anti-cancer medicines used to treat multiple myeloma. Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.
PANOBINOSTAT contains Panobinostat. It works by blocking the action of histone deacetylase in myeloma cells. Thereby, it can prevent myeloma cells from growing and multiplying.
Depending on your medical condition, you are advised to take PANOBINOSTAT for as long as your doctor prescribes it. Sometimes, you may experience common side effects, such as diarrhoea, fatigue, nausea, peripheral oedema, decreased appetite, pyrexia, vomiting and hematologic laboratory abnormalities. Do not be reluctant to talk with your doctor if you persistently experience any of these side effects.
Do not take PANOBINOSTAT if you are allergic to any of its components or if you are pregnant. Do not try to become pregnant as PANOBINOSTAT may cause Embryo-Fetal Toxicity. Advise women not to breastfeed while taking PANOBINOSTAT. Inform your doctor if you are suffering from Hepatic dysfunction, as this increases panobinostat exposure. Your doctor reduces the dose in patients with mild to moderate hepatic (liver) impairment. It is recommended not to be used in people with severe hepatic (liver) impairment. If you feel dizzy or lightheaded when taking panobinostat, you should not operate machinery or drive a car.
Multiple myeloma
PANOBINOSTAT contains Panobinostat, which belongs to the anti-cancer medicines used to treat multiple myeloma. It works by blocking the action of histone deacetylase in myeloma cells. Thereby, it can prevent myeloma cells from growing and multiplying.
Do not take PANOBINOSTAT if you are allergic to any of its contents. Inform your doctor about your health condition and medications to rule out any side effects/interactions. Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking PANOBINOSTAT for as long as your doctor has prescribed. Do not stop PANOBINOSTAT midway. Talk to your doctor before taking PANOBINOSTAT if you have severe allergic reactions to PANOBINOSTAT or other medicines or suffer from any medical illness. Avoid taking PANOBINOSTAT if you are pregnant or breastfeeding because this PANOBINOSTAT can cause harmful effects on the unborn baby. Both women and men using this PANOBINOSTAT should use birth control to avoid pregnancy. Inform your doctor if you have a history of low blood pressure; your doctor will closely monitor and manage it. If you are taking medication to help lower your blood pressure, you may need to reduce or discontinue it while taking panobinostat.
Drug-Drug Interactions: PANOBINOSTAT may interact with medicines used to treat benign prostatic hyperplasia (e.g. alfuzosin), anticoagulant (e.g. apixaban), vaccines (e.g. BCG vaccine, Dengue vaccine), antibiotics (e.g. clarithromycin, ciprofloxacin), antithrombotic drugs (e.g. dabigatran), HIV medications (e.g. efavirenz) and immunomodulating medication (e.g. fingolimod).
Drug-Food Interactions: No interactions found/established.
Drug-Disease Interactions: Inform your doctor if you have Low blood pressure, cardiac toxicity (Arrhythmias, Ischemic Heart Disease, Electrolyte Abnormalities), myelosuppression (decreased activity of bone marrow), renal or hepatic impairment and infections (Bacterial/Fungal/Protozoal/Viral).
Avoid alcohol consumption while on treatment with PANOBINOSTAT.
PANOBINOSTAT should not be taken during pregnancy as it might cause fetal harm. Inform your doctor immediately if you are conceiving while on therapy.
You should not breastfeed when taking PANOBINOSTAT as it is unknown if the panobinostat can pass to your baby in the milk.
PANOBINOSTAT can cause a drop in blood pressure, which can make you feel dizzy, lightheaded or like you are about to faint. If you feel dizzy or lightheaded when taking PANOBINOSTAT, you should not operate machinery or drive a car.
Caution should be exercised. Monitor hepatic enzymes and adjust the dosage if abnormal liver function tests are observed during panobinostat therapy.
Limited information is available. Please inform your doctor before prescribing PANOBINOSTAT if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing PANOBINOSTAT.
The safety and efficacy of PANOBINOSTAT in children has not been established.
Multiple myeloma, also known as myeloma, is a type of bone marrow cancer that affects several areas of the body, such as the spine, skull, pelvis, and ribs.