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About RABEPRAZOLE+MOSAPRIDE

RABEPRAZOLE+MOSAPRIDE belongs to a group of gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). It is also used to treat acidity, indigestion, heartburn and peptic ulcers. Gastroesophageal reflux disease occurs when stomach acid frequently flows back into the food pipe (esophagus); this causes acidity and heartburn. Peptic ulcers are sores that develop on the inner lining of the intestine and stomach.

RABEPRAZOLE+MOSAPRIDE is a combination of two drugs: Rabeprazole (proton pump inhibitor) and Mosapride (prokinetic agent). Rabeprazole works by blocking an enzyme called the gastric proton pump, which is responsible for acid production. Mosapride works by accelerating the gastric emptying time, increasing the food pipe, intestine, and stomach's movement. It also increases the inferior oesophageal (food pipe) sphincter pressure, thereby preventing the backflow of food and acid into the mouth. Together, RABEPRAZOLE+MOSAPRIDE helps prevent acid reflux, thereby providing relief from dyspepsia (indigestion and abdominal pain), acidity, and heartburn.

Take RABEPRAZOLE+MOSAPRIDE as prescribed. You are advised to take RABEPRAZOLE+MOSAPRIDE for as long as your doctor has prescribed it for you depending on your medical condition. In some cases, you may experience certain common side effects such as nausea, stomach pain, diarrhea, flatulence, headache, dizziness, weakness, sleepiness, and flu-like symptoms. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Inform your doctor before taking RABEPRAZOLE+MOSAPRIDE if you have a history of gastrointestinal bleeding or intestinal obstruction. On long-term treatment, RABEPRAZOLE+MOSAPRIDE may cause osteoporosis-related fractures of the hip, wrist, spine, and hypomagnesemia (low magnesium levels). Do not take RABEPRAZOLE+MOSAPRIDE if you are pregnant or breastfeeding unless prescribed by the doctor. RABEPRAZOLE+MOSAPRIDE should not be given to children as safety has not been established. RABEPRAZOLE+MOSAPRIDE may cause drowsiness and dizziness, so drive only if you are alert. Avoid consuming alcohol and RABEPRAZOLE+MOSAPRIDE as it could lead to increased drowsiness and elevate stomach acid production.

Uses of RABEPRAZOLE+MOSAPRIDE

Gastro Esophageal reflux disease (GERD), Heartburn, Hyperacidity, Stomach ulcer

Medicinal Benefits

RABEPRAZOLE+MOSAPRIDE belongs to a group of gastrointestinal agents used to treat gastro-oesophageal reflux disease (GERD). RABEPRAZOLE+MOSAPRIDE is a combination of two drugs: Rabeprazole (proton pump inhibitor) and Mosapride (prokinetic agent). Rabeprazole works by blocking an enzyme called the gastric proton pump, which is responsible for acid production. Mosapride works by accelerating the gastric emptying time, increasing the food pipe, intestine, and stomach movement. It also increases the inferior oesophageal (food pipe) sphincter pressure, thereby preventing the backflow of food and acid into the mouth. Besides this, it also facilitates the intestine's movement, thereby increasing the frequency of bowel movements, softening stools, and reducing abdominal discomfort and pain. Mosapride enhanced the acid-inhibitory effect of PPIs such as Rabeprazole. Collectively, RABEPRAZOLE+MOSAPRIDE helps prevent acid reflux, thereby providing relief from acidity, heartburn, and dyspepsia (indigestion and abdominal pain). 

Directions for Use

Take RABEPRAZOLE+MOSAPRIDE 1-hour prior food or as advised by the doctor. Swallow it as a whole with a glass of water. Do not chew or crush it.

Storage

Store in a cool and dry place away from sunlight

Side Effects of RABEPRAZOLE+MOSAPRIDE

  • Headache
  • Dry mouth
  • Stomach pain
  • Flatulence
  • Diarrhoea
  • Nausea
  • Vomiting
  • Flu like symptoms

In-Depth Precautions and Warning

Drug Warnings

Do not take RABEPRAZOLE+MOSAPRIDE if you are allergic to any of its contents, have a gastrointestinal hemorrhage, porphyria (liver disorder) and cardiac impairment. Inform your doctor before taking RABEPRAZOLE+MOSAPRIDE if you have stomach pain, indigestion, vomiting food or blood or if you pass black stools,  have severe liver or kidney problems, if you are due to have Chromogranin A test. Do not take RABEPRAZOLE+MOSAPRIDE if you are pregnant or breastfeeding unless prescribed by the doctor. RABEPRAZOLE+MOSAPRIDE should not be given to children as safety has not been established. RABEPRAZOLE+MOSAPRIDE should be used with extreme caution in elderly patients since the risk of side effects is high. RABEPRAZOLE+MOSAPRIDE may cause osteoporosis (weak and brittle bones) and hypomagnesemia (low magnesium levels) on long-term treatment, the doctor may advise regular tests for monitoring your condition. Prolonged intake of PPIs or proton pump inhibitors like Rabeprazole may cause brittle bones so intake of Vitamin D and calcium can be additionally given by your doctor while using RABEPRAZOLE+MOSAPRIDE. RABEPRAZOLE+MOSAPRIDE may cause dizziness and drowsiness, so drive only if you are alert. Avoid consuming alcohol along with RABEPRAZOLE+MOSAPRIDE as it could lead to increased drowsiness and can elevate the production of stomach acid. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Drug Interactions

Drug-Drug Interactions: RABEPRAZOLE+MOSAPRIDE may have interaction with a pain killer (ibuprofen, diclofenac, aspirin, naproxen), anti-depressant (duloxetine, amitriptyline), blood thinner (clopidogrel, heparin, warfarin), a drug used to treat hypothyroidism (levothyroxine), anti-HIV (atazanavir, nelfinavir), anti-fungal (ketoconazole, itraconazole, voriconazole, posaconazole), anti-cancer (methotrexate), vitamin (cyanocobalamin), medicines to help you to sleep or feel more relaxed (diazepam, zolpidem).

Drug-Food Interactions: Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increases acidity and heartburn. RABEPRAZOLE+MOSAPRIDE may have interaction with St.John’s wort (herbal supplement used to treat depression). 

Drug-Disease Interactions: RABEPRAZOLE+MOSAPRIDE may have interactions with gastrointestinal bleeding, intestinal obstruction, Clostridium difficile-associated diarrhoea (CDAD), liver disease, bone fractures, hypomagnesemia (low levels of magnesium).

Drug-Drug Interactions Checker List:

  • IBUPROFEN
  • DICLOFENAC
  • ASPIRIN
  • NAPROXEN
  • DULOXETINE
  • AMITRIPTYLINE
  • CLOPIDOGREL
  • WARFARIN
  • HEPARIN
  • LEVOTHYROXINE
  • ATAZANAVIR
  • NELFINAVIR
  • KETOCONAZOLE
  • ITRACONAZOLE
  • VORICONAZOLE
  • POSACONAZOLE
  • METHOTREXATE
  • CYANOCOBALAMIN
  • DIAZEPAM
  • ZOLPIDEM
  • Safety Advice

    • Safety Warning

      Alcohol

      unsafe

      You are recommended to avoid consumption of alcohol with RABEPRAZOLE+MOSAPRIDE as it may increase the risk of stomach bleeding and ulcer.

    • Safety Warning

      Pregnancy

      caution

      Do not take RABEPRAZOLE+MOSAPRIDE if you are pregnant or planning for pregnancy. Please consult your doctor. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

    • Safety Warning

      Breast Feeding

      caution

      Do not take RABEPRAZOLE+MOSAPRIDE if you are breastfeeding. Please consult your doctor before intake of RABEPRAZOLE+MOSAPRIDE. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

    • Safety Warning

      Driving

      caution

      RABEPRAZOLE+MOSAPRIDE may cause dizziness and sleepiness. Do not drive or operate machinery unless you are alert.

    • Safety Warning

      Liver

      caution

      Take RABEPRAZOLE+MOSAPRIDE with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required.

    • Safety Warning

      Kidney

      caution

      Take RABEPRAZOLE+MOSAPRIDE with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Rabeprazole in RABEPRAZOLE+MOSAPRIDE may cause kidney problems in rare cases, so if you are urinating less than usual, or have blood coming in your urine, let your doctor know about this immediately.

    • Safety Warning

      Children

      unsafe

      RABEPRAZOLE+MOSAPRIDE should not be given to children as the safety and effectiveness were not established.

    Habit Forming

    No

    Diet & Lifestyle Advise

    • Eat smaller meals more often.
    • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
    • Maintain a healthy weight by regular exercising.
    • Avoid lying down after eating as it causes acid reflux.
    • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
    • Practice relaxation techniques and avoid stress by doing yoga or meditation.
    • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
    • Avoid sitting continuously as it may trigger acidity. Take a break of 5 minutes every hour by doing brisk walking or stretching.

    Special Advise

    • Inform your doctor before taking RABEPRAZOLE+MOSAPRIDE if you are due to have Chromogranin A test.
    • Prolonged intake of PPIs or proton pump inhibitors like Rabeprazole may cause diarrhoea, autoimmune disease (lupus), and brittle bones. So tell your doctor if you have these symptoms.
    • Patients with a history of gastrointestinal bleeding or ulcer, movement disorders, or mechanical obstruction, or perforations (holes) in the intestine should avoid using RABEPRAZOLE+MOSAPRIDE and contact their doctor before using it.

    Patients Concern

    Disease/Condition Glossary

    Gastroesophageal reflux disease (GERD): The stomach is usually protected from acid by a mucous layer. In some cases, due to excess acid production, the mucous layer gets eroded, which leads to complications like GERD, acidity, heartburn and peptic ulcers. Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the food pipe (oesophagus). This backflow (acid reflux) irritates the food pipe and causes heartburn and acidity. Symptoms include heartburn, sour or bitter taste in the mouth, and difficulty swallowing. 

    FAQs

    How does RABEPRAZOLE+MOSAPRIDE work?

    RABEPRAZOLE+MOSAPRIDE contains Rabeprazole (proton pump inhibitor) and Mosapride (prokinetic agent). Rabeprazole works by blocking the action of an enzyme called gastric proton pump responsible for stomach acid production. Mosapride works by increasing the inferior oesophageal (food pipe) sphincter pressure, thereby preventing the backflow of food and acid towards the food pipe or mouth. Together, RABEPRAZOLE+MOSAPRIDE helps in preventing acid reflux, thereby provides relief from acidity.

    Is it safe to take RABEPRAZOLE+MOSAPRIDE for longer durations?

    Do not take RABEPRAZOLE+MOSAPRIDE for longer durations unless prescribed by the doctor. Talk to your doctor if you do not find symptomatic relief. The doctor may monitor your condition regularly if you are on long term treatment with RABEPRAZOLE+MOSAPRIDE.

    How can I minimize symptoms of hyperacidity after taking meal?

    Avoid lying down immediately after meals to prevent acid reflux. Raise the head of the bed 10-20 cm by putting a pillow so that the head and chest are above the waist. This helps in preventing acid reflux.

    Does RABEPRAZOLE+MOSAPRIDE cause bone fractures?

    RABEPRAZOLE+MOSAPRIDE contains rabeprazole which might increase the risk of fracture in the wrist, hip or spine. This mainly occurs in people taking RABEPRAZOLE+MOSAPRIDE for longer durations. Prolonged use of RABEPRAZOLE+MOSAPRIDE may cause low magnesium level in your bones. Inform your doctor if you have osteoporosis or taking corticosteroids, your doctor may prescribe calcium and vitamin D supplements.

    How to cope with dry mouth?

    Dry mouth could be a side-effect of RABEPRAZOLE+MOSAPRIDE. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might help in stimulating saliva and thereby prevents drying of the mouth.

    Can I stop taking RABEPRAZOLE+MOSAPRIDE if I feel well?

    Do not discontinue RABEPRAZOLE+MOSAPRIDE without consulting your doctor. To treat your condition effectually continue taking RABEPRAZOLE+MOSAPRIDE for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking RABEPRAZOLE+MOSAPRIDE.