Relugolix+estradiol+norethindrone Acetate
About Relugolix+estradiol+norethindrone Acetate
Relugolix+estradiol+norethindrone Acetate is used to treat moderate-to-severe symptoms of uterine fibroids. It helps reduce heavy menstrual bleeding associated with uterine fibroids. Uterine fibroids are non-cancerous growths in the uterus that may develop during a woman’s childbearing age.
Relugolix+estradiol+norethindrone Acetate contains relugolix, estradiol and norethisterone acetate. Relugolix reduces the production of certain hormones (estrogen and progesterone). Estradiol and norethindrone acetate help maintain hormonal balance and reduce side effects.
The common side effects of Relugolix+estradiol+norethindrone Acetate include hot flashes, decreased sexual interest, headache, hair loss, night sweats, and mood changes. These side effects may vary from person to person. If you notice any side effects that are not manageable, please consult your doctor.
Inform your doctor if you are allergic to Relugolix+estradiol+norethindrone Acetate or any other components of it. Avoid taking Relugolix+estradiol+norethindrone Acetate if you are pregnant or breastfeeding. Relugolix+estradiol+norethindrone Acetate is not recommended for children below 12 years of age.
Medicinal Benefits
- Reduces heavy menstrual bleeding associated with uterine fibroids.
- Relieves pelvic pain and discomfort in endometriosis.
- Helps shrink fibroids by controlling hormone levels.
- Maintains hormonal balance with added estrogen and progestin.
- Reduces risk of bone loss compared to hormone suppression alone.
- Improves overall quality of life by controlling symptoms effectively.
Directions for Use
- Relugolix+estradiol+norethindrone Acetate can be taken with or without food as advised by the doctor.
- Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
- It is advised to take Relugolix+estradiol+norethindrone Acetate within the first 7 days of start of the menstrual bleeding.
- Swallow Relugolix+estradiol+norethindrone Acetate as a whole with a glass of water.
- Do not break, crush or chew it
Storage
Side Effects of Relugolix+estradiol+norethindrone Acetate
- Hot flushes
- Muscle weakness
- Loss of interest in sexual intercourse
- Difficulty sleeping
- Hair loss
- Night sweats
- Mood swings
- Abdominal pain
Medicines Containing this Salt
View AllDrug Warnings
- If you are allergic to Relugolix+estradiol+norethindrone Acetate or any other medicines, please tell your doctor.
- Relugolix+estradiol+norethindrone Acetate can affect the unborn baby when used in pregnancy. Hence, Relugolix+estradiol+norethindrone Acetate is not indicated for use in pregnant and breastfeeding women.
- Relugolix+estradiol+norethindrone Acetate is not recommended for children below 12 years of age.
- If you have a seizure or unusual changes in mood or behaviour, inform your doctor immediately.
- Relugolix+estradiol+norethindrone Acetate is contraindicated in patients with liver disease, women with history of thromboembolic disorders, uncontrolled BP, liver tumours, genital bleeding, depression, fits, or weak bones, as it is contraindicated in these patients.
- Caution should be exercised while taking Relugolix+estradiol+norethindrone Acetate in patients with thromboembolic disorders, depression, mood disorders, bone loss, elevated blood pressure, a change in menstrual bleeding pattern and severe uterine bleeding.
- Inform your doctor if you are taking any hormonal contraceptive pills, as concomitant use is contraindicated.
Drug Interactions
Drug-Drug Interaction: Inform your doctor if you are taking any of these medicines, as there may be an interaction.
- Strong P-gp inhibitors (cyclosporin)
• Potential effect: May increase the levels of Relugolix+estradiol+norethindrone Acetate leading to severe side effects. Hence, it should be avoided. - Antifungal drugs (ketoconazole)
• Potential effect: May increase the effectiveness of Relugolix+estradiol+norethindrone Acetate. - Blood thinners (warfarin)
• Potential effect: May increase the levels of Relugolix+estradiol+norethindrone Acetate - Hormonal contraceptives (levonorgestrel)
• Potential effect: May reduce the effectiveness of Relugolix+estradiol+norethindrone Acetate
Drug-Food Interaction: No interactions found/established.
Drug-Disease Interaction: Inform your doctor if you have a history of the following conditions before taking Relugolix+estradiol+norethindrone Acetate, as it may worsen your condition or cause complications.
- Liver diseases
- Liver tumors
- Depression
- Fits
- Weak bones
- Genital bleeding
- Hormonal cancer
- Blood clot
- increased blood pressure
Drug-Drug Interactions Checker List:
Safety Advice
Alcohol
unsafeYou are recommended to avoid alcohol consumption while taking Relugolix+estradiol+norethindrone Acetate to avoid unpleasant side effects. Alcohol intake, along with Relugolix+estradiol+norethindrone Acetate, may cause increased drowsiness.
Pregnancy
unsafeRelugolix+estradiol+norethindrone Acetate is contraindicated for use in pregnant women. Therefore, let your doctor know if you are pregnant or planning for pregnant before taking Relugolix+estradiol+norethindrone Acetate.
Breast Feeding
unsafeRelugolix+estradiol+norethindrone Acetate should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. Please consult your doctor.
Driving
safe if prescribedRelugolix+estradiol+norethindrone Acetate is unlikely to affect your ability to drive. However, drive or operate heavy machinery only if you are alert.
Liver
consult your doctorIf you have a history of liver disease, inform the doctor before taking Relugolix+estradiol+norethindrone Acetate. Relugolix+estradiol+norethindrone Acetate is not recommended for use in patients with severe liver impairment.
Kidney
consult your doctorIf you have a history of liver disease, inform the doctor before taking Relugolix+estradiol+norethindrone Acetate.
Children
unsafeRelugolix+estradiol+norethindrone Acetate is not recommended for use in children below 12 years of age.
Habit Forming
Diet & Lifestyle Advise
Diet
- Include calcium- and vitamin D–rich foods (milk, curd, leafy greens) to support bone health.
- Eat a balanced diet with fruits, vegetables, and whole grains for overall hormonal health.
- Limit caffeine, sugary, and processed foods as they may worsen symptoms like bloating.
- Reduce excess salt intake and stay well hydrated to help manage fluid retention.
Lifestyle changes
- Engage in regular exercise (especially weight-bearing activities) to maintain bone strength.
- Maintain a healthy weight and routine by getting proper sleep and staying active daily.
Habits
- Avoid smoking and limit alcohol intake to reduce side effects and protect bone health.
Stress control
- Practice relaxation techniques like meditation, deep breathing, or yoga to reduce stress.
- Stay physically active with light exercises such as walking to improve mood and reduce tension.
Patients Concern
Disease/Condition Glossary
Uterine fibroids: These are non-cancerous growths in the uterus that may develop during a woman’s childbearing age. Symptoms include heavy menstrual bleeding, pelvic pain, and prolonged periods.
FAQs
Relugolix+estradiol+norethindrone Acetate is used to treat heavy menstrual bleeding caused by uterine fibroids in premenopausal women.
Relugolix+estradiol+norethindrone Acetate helps reduce hormone levels that contribute to fibroid symptoms and provides low-dose estrogen and progesterone to maintain hormonal balance and protect bones.
Hormonal contraceptives should not be used together with Relugolix+estradiol+norethindrone Acetate. It is advised to inform your doctor before starting treatment with Relugolix+estradiol+norethindrone Acetate.
Relugolix+estradiol+norethindrone Acetate may decrease bone density, which may increase the chances of fractures or broken bones. Talk to the doctor about the risks and how to prevent them.
Many women notice improvement in bleeding within the first few weeks, but the response may vary from person to person.
Relugolix+estradiol+norethindrone Acetate may cause side effects like hot flashes, decreased sexual interest, headache, hair loss, night sweats, and mood changes.If you have a history of liver disease, inform the doctor before receiving Relugolix+estradiol+norethindrone Acetate. If you notice any side effects that are not manageable, please consult your doctor.
