SACUBITRIL+VALSARTAN belongs to a class of cardiovascular agents that is used in the treatment of heart failure. It helps to reduce the risk of death and hospitalization in adults with chronic heart failure. Also, it can be used in children 1 to less than 18 years old to treat heart failure. Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should.
SACUBITRIL+VALSARTAN is a combination of two medicines: Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. Together, SACUBITRIL+VALSARTAN helps in the treatment of heart failure.
Take SACUBITRIL+VALSARTAN with or without food or as directed by your doctor. Do not crush, chew or break the tablet, swallow it as a whole with a glass of water. You are advised to take SACUBITRIL+VALSARTAN for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side-effects such as cough, dizziness, nausea, diarrhea, weakness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
To treat your condition effectually, continue taking SACUBITRIL+VALSARTAN for as long as your doctor has prescribed it. Try not to stop taking it on your own as it may cause a sudden increase the blood pressure, chest pain, or heart attack. Do not be reluctant to speak with your doctor if you experience any difficulty while taking SACUBITRIL+VALSARTAN. Do not take SACUBITRIL+VALSARTAN with ACE inhibitors (such as captopril, enalapril) since the risk of side effects may increase. Do not take SACUBITRIL+VALSARTAN for at least 36 hours before or after taking an ACE inhibitor drug. Inform your doctor before taking SACUBITRIL+VALSARTAN if you have kidney or liver problems, if you are pregnant or breastfeeding, or if you have a history of hereditary angioedema (rapid oedema or swelling beneath the area of skin).
Heart failure.
SACUBITRIL+VALSARTAN is a combination of two medicines Valsartan and sacubitril. Valsartan belongs to the class of drugs called angiotensin receptor blockers (ARBs) that block the effect of angiotensin II receptors that tighten the blood vessels. By blocking the effect of angiotensin II receptors, Valsartan makes it easier for the heart to pump blood to all body parts by relaxing and widening the blood vessels. Sacubitril belongs to the class of drugs known as neprilysin inhibitors which work by relaxing and widening the blood vessels and makes it easier for the heart to pump blood to all body parts. SACUBITRIL+VALSARTAN helps in the treatment of certain types of heart failure. It may also help you to live longer and lowers the frequency of hospitalizations for heart failure.
Keep your doctor informed if you have kidney or liver diseases. Discuss with your doctor if you are taking any other medicines along with SACUBITRIL+VALSARTAN. Avoid smoking and alcohol consumption. Pregnant women and breastfeeding women should consult their doctor before taking SACUBITRIL+VALSARTAN. A prolonged intake of SACUBITRIL+VALSARTAN can cause an altered potassium level so, regular monitoring of potassium is required. Driving and operating heavy machinery should not be done as it may cause dizziness and drowsiness. Orthostatic hypotension (sudden lowering of blood pressure n standing) might occur, so patients using SACUBITRIL+VALSARTAN should get up with caution. Speak to your doctor if you have diabetes before taking SACUBITRIL+VALSARTAN. Inform your doctor about your current medicines such as aliskiren (medication to treat high blood pressure), any other heart or blood pressure medicines, lithium, mineral supplements that contain potassium. Inform your doctor if you feel light-headed or have little or no urination, rapid weight gain, swelling in your hands, feet, or ankles after taking SACUBITRIL+VALSARTAN.
Drug-Drug Interaction: Pain medication (aspirin), a medicine used to lower cholesterol (rosuvastatin, atorvastatin), medicine to treat both type 1 and type 2 diabetes (insulin detemir), blood pressure medication (metoprolol), a medication used in the management of asthma (budesonide/formoterol).
Drug-Food Interaction: Maintain low salt and low-fat diet while taking SACUBITRIL+VALSARTAN. Avoid consuming food rich in potassium, such as potassium-containing salt substitutes or over-the-counter potassium supplements. Avoid smoking and alcohol consumption.
Drug-Disease Interaction: Hypotension (low blood pressure), diabetes, angioedema (rapid edema or swelling beneath the skin), hyperkalemia (high potassium in the blood), renal artery stenosis, renal/liver disease, renal impairment.
You are recommended to avoid alcohol consumption while taking SACUBITRIL+VALSARTAN to avoid unpleasant side-effects.
It is not recommended to take SACUBITRIL+VALSARTAN while you are pregnant. Please consult your doctor. Your doctor will decide whether SACUBITRIL+VALSARTAN can be given to pregnant women or not.
It is not recommended to take SACUBITRIL+VALSARTAN while you are breast-feeding. Please consult your doctor. Your doctor will decide whether SACUBITRIL+VALSARTAN can be given to breast-feeding mothers or not.
SACUBITRIL+VALSARTAN may cause dizziness, do not drive or operate heavy machinery if you feel dizzy.
Dose adjustment may be needed. SACUBITRIL+VALSARTAN should be used with caution in patients with liver impairment/liver disease.
Dose adjustment may be needed. SACUBITRIL+VALSARTAN should be used with caution in patients with kidney impairment/kidney disease.
SACUBITRIL+VALSARTAN can be used to treat heart failure in children who are at least 1 year old when prescribed by a child specialist
Heart failure is a chronic condition in which the heart cannot pump blood as effectively as it should. Heart failure may occur due to certain conditions like high blood pressure, swelling or damage of heart muscle, faulty heart valves, or narrow arteries in the heart. Symptoms of heart failure include shortness of breath, tiredness, fast heartbeat, and swollen legs.