SAQUINAVIR is an antiretroviral medicine used in the treatment of HIV infection. HIV is a retroviral infection that attacks and destroys immune cells. This reduces the body's ability to fight infections and illnesses. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Syndrome (AIDS). This medicine is used in combination with ritonavir and other antiviral medicines.
SAQUINAVIR contains Saquinavir, which belongs to the class of protease inhibitors. It works by inhibiting the protease enzyme production, which is required for the HIV-infected cells to make new viruses. Therefore, SAQUINAVIR inhibits viral replication.
SAQUINAVIR may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, depression, fever, tiredness, blood in urine, diarrhea, and itching. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. SAQUINAVIR should be taken as advised by your doctor. Your doctor will decide the dose of the medicine based on your health condition. Do not take more than the recommended dose.
SAQUINAVIR should be avoided if you are allergic to it. This medicine is contraindicated in patients with congenital or documented acquired QT prolongation, AV block, anaphylactic reactions, Stevens-Johnson syndrome, use of SAQUINAVIR with ritonavir in severe hepatic impairment, combination of SAQUINAVIR and ritonavir with CYP3A substrates and rifampicin due to hepatotoxicity as it can cause serious side effects. Hence, avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, diabetes, or immune reconstitution syndrome on priority. SAQUINAVIR should be given to pregnant and breastfeeding women only if recommended by the doctor.
HIV Infection.
SAQUINAVIR contains Saquinavir (protease inhibitor), which works by inhibiting the protease enzyme production required for the HIV-infected cells to make new viruses. This causes inhibition of viral replication. SAQUINAVIR is used alone or in combination with other antiretroviral medicines to help reduce the symptoms, control the infection, and prevent opportunistic infections effectively. It also helps in improving the quality of life of a patient with HIV.
Avoid taking SAQUINAVIR if you are allergic to it. Caution should be exercised if you have liver/kidney disease, cardiovascular conditions, Congenital Long QT Syndrome, diabetes, hepatitis B infection, and hepatitis C infection. This medicine is contraindicated in patients with congenital or documented acquired QT prolongation, AV block, anaphylactic reactions, Stevens-Johnson syndrome, use of SAQUINAVIR with ritonavir in severe hepatic impairment, combination of SAQUINAVIR and ritonavir with CYP3A substrates and rifampicin due to hepatotoxicity as it can cause serious side effects. Hence, avoid using this medicine under such conditions. SAQUINAVIR should be given to pregnant and breastfeeding women only if recommended by the doctor. This medicine may cause dizziness; hence, avoid driving or operating machines while taking SAQUINAVIR. Children below 16 years of age should take SAQUINAVIR only if prescribed by the doctor.
Drug-Drug Interactions: SAQUINAVIR may interact with alpha-adrenergic blockers (prazosin, alfuzosin), gastrointestinal medicine (cisapride), contraceptives (ethynyl estradiol, norethindrone), immunosuppressants (cyclosporin, sirolimus, tacrolimus), antibiotics (clarithromycin), antiretroviral drugs (efavirenz, nevirapine, indinavir), antidepressant drugs (phenytoin, phenobarbitone, carbamazepine), etc.
Drug-Food Interactions: Avoid smoking and alcohol consumption.
Drug-Disease Interactions: Inform your doctor if you have cardiac problems, liver or kidney disease, Congenital Long QT Syndrome, or diabetes.
Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption while receiving SAQUINAVIR to prevent serious side effects.
If you are pregnant or planning pregnancy, inform your doctor before taking SAQUINAVIR. Your doctor may prescribe this medicine if the benefits outweigh the risks.
It is unknown whether saquinavir is excreted in human milk. Mothers should not breastfeed if they are on SAQUINAVIR because of the risk of HIV-1 transmission and major adverse effects in nursing infants.
Avoid driving vehicles as it may cause dizziness and affect your ability to drive. Hence, it is advised to drive only when you are alert.
There have been instances of worsening liver illness in people with underlying hepatitis B or C, cirrhosis, persistent drinking, and/or other underlying liver abnormalities after using SAQUINAVIR. If you have such conditions, inform your doctor before taking SAQUINAVIR.
Patients with renal impairment do not require any initial dose adjustments. However, patients with severe renal impairment or end-stage renal disease (ESRD) have not been examined, and it should be used with caution in place with renal impairment.
The use of SAQUINAVIR in children below 16 years old is unclear. Hence, consult your pediatrician. It should be given only upon pediatrician advice for children.
HIV Infection: Human Immunodeficiency Virus (HIV) is a retroviral infection that attacks and damages the cells of the immune system. This weakens the ability to fight against infections and diseases. If this condition is left untreated, it can lead to Acquired Immuno Deficiency Virus (AIDS). Symptoms of HIV include headache, fever, chills, joint pain, fatigue, swollen lymph nodes, sore throat, mouth nodes, muscle aches, etc. SAQUINAVIR helps reduce the symptoms, control the infection, and also helps improve the HIV patient’s quality of life.