Do not take TOPIROXOSTAT if you are allergic to its ingredients. The safety of TOPIROXOSTAT in pregnant women is uncertain. As a result, inform your doctor; your doctor will consider the benefits and potential hazards before giving this medication. TOPIROXOSTAT is not known if it is excreted in human milk. It should not be used if the potential advantages outweigh the hazards to the newborn. If you are breastfeeding, consult with your doctor before using this medication. This medication may increase your chances of significant heart and blood vessel problems, such as unstable chest discomfort, heart attack, or stroke. Contact your doctor immediately if you experience chest pain, difficulty breathing, a sudden or severe headache, or problems with vision, speech, or walking.

Drug-Drug Interactions: TOPIROXOSTAT is known to interact with immunosuppressive medication (e.g. Azathioprine, Methotrexate), anticancer medications (e.g. Mercaptopurine), medicines used to prevent cardiovascular disease (e.g. Rosuvastatin) and medications used to treat asthma and chronic obstructive pulmonary disease (e.g. Theophylline).

Drug-Food Interactions: TOPIROXOSTAT is known to interact with alcohol.

Drug-Disease Interactions: The presence of other medical issues may interfere with the usage of this medication. Inform your doctor about all your medical problems, including cancers, brain or blood vessel illness, diabetes, heart disease, kidney or liver disease, or organ transplant.

• Adopting a balanced diet is an important lifestyle component in gout therapy or management.
• A healthy diet generally includes plant-based foods such as vegetables, fruits, legumes, and whole grains.
• Stay well-hydrated by drinking water.
• Consume uric acid-lowering foods.  Low-fat dairy products are one example. Calcium-rich foods may help reduce gout attacks while also protecting your bones.
• Citrus fruits and other vitamin C-rich foods (such as strawberries and peppers) may benefit people with gout. Eating cherries or juice can help minimize gout episodes and pain.
• Being overweight raises the risk of having gout, while reducing weight reduces the risk.
• Avoiding purine-rich meals such as red meat, some seafood, and alcohol may help you lower uric acid levels in your blood and lessen your risk of gout attacks.
• Avoid meals and beverages containing high fructose, and restrict your consumption of naturally sweet fruit juices.
• Avoid drinking alcohol and quit smoking.

• The doctor will monitor your kidney function constantly before and during treatment with TOPIROXOSTAT.
• A liver function test should be done regularly to monitor liver enzymes as TOPIROXOSTAT can cause liver enzyme fluctuations.
• If you are undergoing a urine test, inform the lab technician or the doctor about using TOPIROXOSTAT.