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Loette Tablet is used for contraception and treating dysmenorrhea (irregular and painful periods). It contains Ethinylestradiol and Levonorgestrel, which maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Also, it prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). It may also change the lining of the uterus to prevent the development of a pregnancy. It may cause side effects such as stomach pain, headache, nausea, breast pain, weight gain, and irregular uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Loette Tablet:
Taking Loette Tablet with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Loette Tablet with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Coadministration of Acitretin with Loette Tablet can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Loette Tablet together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use acitretin if you are pregnant. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Taking Loette Tablet with Tranexamic acid may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Tranexamic acid with Loette Tablet may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
LevonorgestrelEtretinate
Critical
How does the drug interact with Loette Tablet:
Using etretinate and Loette Tablet can cause severe birth defects.

How to manage the interaction:
Taking Etretinate with Loette Tablet can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Taking thalidomide together with Loette Tablet may increase the risk of blood clots and that may lead to serious complications.

How to manage the interaction:
Although taking thalidomide and Loette Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Loette Tablet:
Taking Loette Tablet and Amprenavir together may make amprenavir less effective.

How to manage the interaction:
Co-administration of Loette Tablet with Amprenavir can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Loette Tablet:
Taking carbamazepine and Loette Tablet may reduce the effects of Loette Tablet, which might result in a higher risk of breakthrough bleeding and unplanned pregnancy.

How to manage the interaction:
Although taking carbamazepine and Loette Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Loette Tablet may interfere with anastrozole's function and make it less effective in treating the condition.

How to manage the interaction:
There may be a possibility of interaction between Anastrozole and Loette Tablet, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Loette Tablet:
When coupled with Dabrafenib, the blood level of Loette Tablet can be reduced.

How to manage the interaction:
There may be a possibility of interaction between Dabrafenib and Loette Tablet, but it can be taken if prescribed by a doctor. If you are taking hormone replacement therapy for menopause, you should notify your doctor if you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Loette Tablet:
When Loette Tablet and clindamycin are taken together, the effects of Clindamycin can be reduced.

How to manage the interaction:
There may be a possibility of interaction between Loette Tablet and clindamycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ETHINYLESTRADIOL-0.02MG+LEVONORGESTREL-0.1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ETHINYLESTRADIOL-0.02MG+LEVONORGESTREL-0.1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking Grapefruit or Grapefruit juice while on the treatment with Ethinylestradiol, Levonorgestrel can lead to increase in blood levels of Ethinylestradiol, Levonorgestrel. Avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ethinylestradiol, Levonorgestrel.

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