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Loette Tablet is used for contraception and treating dysmenorrhea (irregular and painful periods). It contains Ethinylestradiol and Levonorgestrel, which maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Also, it prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). It may also change the lining of the uterus to prevent the development of a pregnancy. It may cause side effects such as stomach pain, headache, nausea, breast pain, weight gain, and irregular uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Loette Tablet:
Taking Loette Tablet with Tranexamic acid may increase the risk of blood clot formation.

How to manage the interaction:
Taking Loette Tablet with Tranexamic acid is not recommended, as it can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you suffer from chest discomfort, shortness of breath, blood in the urine, blood in the cough, sudden loss of vision, and pain, redness, or swelling in your arm or leg, consult doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Taking Loette Tablet with Tranexamic acid may increase the risk of blood clot formation which can lead to serious conditions such as heart problems and kidney failure.

How to manage the interaction:
Taking Tranexamic acid with Loette Tablet may leads to an interaction but can be taken if prescribed by the doctor. However, if you experience chest pain; shortness of breath; coughing up blood; blood in the urine; sudden loss of vision; and pain, redness, or swelling in your arm or leg, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Coadministration of Acitretin with Loette Tablet can increase the risk and severity of birth defects in unborn when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Loette Tablet together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Never use acitretin if you are pregnant. Do not stop using any medications without talking to a doctor.
LevonorgestrelEtretinate
Critical
How does the drug interact with Loette Tablet:
Using etretinate and Loette Tablet can cause severe birth defects.

How to manage the interaction:
Taking Etretinate with Loette Tablet can cause an interaction, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
Phenytoin may lower ethinyl estradiol levels in the blood and its effects. You may be more likely to experience breakthrough bleeding and unexpected pregnancy if you use low-dose oral contraceptives.

How to manage the interaction:
Although taking Phenytoin and Loette Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you are on hormone replacement therapy for menopause, inform a doctor if your symptoms are no longer being controlled or if you are experiencing abnormal bleeding. Do not stop using any medications without a doctor's advice.
How does the drug interact with Loette Tablet:
When used with Loette Tablet, the effectiveness of Exemestane might be reduced.

How to manage the interaction:
Although taking Exemestane and Loette Tablet together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Loette Tablet:
Taking carbamazepine and Loette Tablet may reduce the effects of Loette Tablet, which might result in a higher risk of breakthrough bleeding and unplanned pregnancy.

How to manage the interaction:
Although taking carbamazepine and Loette Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Loette Tablet:
When Loette Tablet and clindamycin are taken together, the effects of Clindamycin can be reduced.

How to manage the interaction:
There may be a possibility of interaction between Loette Tablet and clindamycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Loette Tablet:
When taken together ethinyl estradiol may interfere with letrozole's activity and make it less effective in treating the condition.

How to manage the interaction:
Although taking Letrozole and Loette Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not stop using any medications without a doctor's advice.
How does the drug interact with Loette Tablet:
Taking rifabutin with ethinyl estradiol it may significantly reduces the blood levels.

How to manage the interaction:
There may be a possibility of interaction between Loette Tablet and Rifabutin, but it can be taken if prescribed by a doctor. If you use hormone replacement therapy for menopause, inform a doctor if experience any unusual symptoms or if you develop unusual bleeding. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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ETHINYLESTRADIOL-0.02MG+LEVONORGESTREL-0.1MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ETHINYLESTRADIOL-0.02MG+LEVONORGESTREL-0.1MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking Grapefruit or Grapefruit juice while on the treatment with Ethinylestradiol, Levonorgestrel can lead to increase in blood levels of Ethinylestradiol, Levonorgestrel. Avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ethinylestradiol, Levonorgestrel.

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