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Overy-L Tablet 21's is used for contraception and treating dysmenorrhea (irregular and painful periods). It contains Ethinylestradiol and Levonorgestrel, which maintains a normal menstrual cycle (periods) in women. It works by fulfilling the deficiency of estrogen hormone, thereby preventing symptoms like night sweats, hot flashes, and mood swings. Also, it prevents the release of an egg from the ovary (female reproductive cells) or prevents fertilization of an egg by sperm (male reproductive cells). It may also change the lining of the uterus to prevent the development of a pregnancy. It may cause side effects such as stomach pain, headache, nausea, breast pain, weight gain, and irregular uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-drug interactions: Overy-L Tablet 21's may have an interaction with anti-epilepsy medicines (primidone, phenytoin, carbamazepine), medications used to treat tuberculosis (rifampicin, rifabutin), drugs used to treat HIV (ritonavir, efavirenz, paritaprevir) medicine used to treat fungal infections (griseofulvin, ketoconazole, itraconazole, posaconazole).

Drug-Food Interactions: Overy-L Tablet 21's interacts with St. John's wort (an antidepressant herbal supplement). Also, alcohol consumption and grapefruit juice should not be included with the Overy-L Tablet 21's.

Drug-Disease Interactions: Inform your doctor if you smoke, have or have ever had liver or kidney disease, heart disease, hypertension, diabetes mellitus, liver disease, abnormal uterine bleeding, breast, cervix, uterus cancer, or anaemia.

Drug-Drug Interactions

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How does the drug interact with Overy-L Tablet:
Using Etretinate with Ethinylestradiol, Levonorgestrel can increase the risk of side effects during pregnancy.

How to manage the interaction:
Taking Etretinate with Ethinylestradiol, Levonorgestrel can cause an interaction, consult a doctor before taking it. In case you experience any unusual symptoms, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Overy-L Tablet:
Co-administration of Acitretin with Ethinylestradiol, Levonorgestrel can increase the risk of side effects during pregnancy.

How to manage the interaction:
Taking Acitretin with Ethinylestradiol, Levonorgestrel together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not stop using any medications without talking to a doctor.
How does the drug interact with Overy-L Tablet:
Taking Ethinylestradiol, Levonorgestrel with Tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Ethinylestradiol, Levonorgestrel with Tranexamic acid can lead to an interaction, but can be taken if a doctor has prescribed it. However, if you experience any symptoms like chest tightness, shortness of breath, blood in the urine, blood in the cough, disturbances in eye sight or swelling in the arms or legs, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol, Levonorgestrel with Topiramate together may decrease the blood levels of Ethinylestradiol, Levonorgestrel.

How to manage the interaction:
Although there is a possibility of interaction between Ethinylestradiol, Levonorgestrel with Topiramate, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like menstrual irregularities, dryness in the vaginal region or feeling of warmth in the upper part of the body, consult a doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol with Mycophenolic acid may lower the blood levels and effects of Ethinylestradiol and Levonorgestrel.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid with Ethinylestradiol and Levonorgestrel, but they can be taken together if a doctor has prescribed them. However, if you are taking hormone replacement therapy for menopause, and you notice an increase in the frequency or severity of your symptoms, such as hot flashes, vaginal dryness, or irregular bleeding, consult a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol, Levonorgestrel with Exemestane together may decrease the blood levels of Exemestane.

How to manage the interaction:
Although there is a possibility of interaction between Ethinylestradiol, Levonorgestrel with Exemestane, they can be taken if prescribed by a doctor. In case you experience any unusual side effects, consult a doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol, Levonorgestrel with Amprenavir together may decrease the blood levels of Ethinylestradiol, Levonorgestrel.

How to manage the interaction:
Although there is a possibility of interaction between Ethinylestradiol, Levonorgestrel with Amprenavir, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like menstrual irregularities, dryness in the vaginal region or feeling of warmth in the upper part of the body, consult a doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol, Levonorgestrel with Bexarotene together may decrease the blood levels of Ethinylestradiol, Levonorgestrel.

How to manage the interaction:
Although there is a possibility of interaction between Ethinylestradiol, Levonorgestrel with Bexarotene, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like menstrual irregularities, dryness in the vaginal region or feeling of warmth in the upper part of the body, consult a doctor. Do not stop taking any medications without consulting a doctor.
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol, Levonorgestrel with Rifapentine together may decrease the blood levels of Ethinylestradiol, Levonorgestrel.

How to manage the interaction:
Although there is a possibility of interaction between Ethinylestradiol, Levonorgestrel with Rifapentine, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like menstrual irregularities, dryness in the vaginal region or feeling of warmth in the upper part of the body, consult a doctor. Do not stop taking any medications without consulting a doctor.
Severe
How does the drug interact with Overy-L Tablet:
Co-administration of Ethinylestradiol, Levonorgestrel with Mycophenolate Mofetil together may decrease the blood levels of Ethinylestradiol, Levonorgestrel.

How to manage the interaction:
Although there is a possibility of interaction between Ethinylestradiol, Levonorgestrel with Mycophenolate Mofetil, they can be taken if prescribed by a doctor. In case you experience any unusual symptoms like menstrual irregularities, dryness in the vaginal region or feeling of warmth in the upper part of the body, consult a doctor. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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ETHINYLESTRADIOL-0.03MG+LEVONORGESTREL-0.15MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ETHINYLESTRADIOL-0.03MG+LEVONORGESTREL-0.15MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Taking Grapefruit or Grapefruit juice while on the treatment with Ethinylestradiol, Levonorgestrel can lead to increase in blood levels of Ethinylestradiol, Levonorgestrel. Avoid or limit the consumption of grapefruit and grapefruit juice during treatment with Ethinylestradiol, Levonorgestrel.

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