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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Spazio Kit Tablet 5's is used for the medical termination of the pregnancy before 63 days after the first day of the last menses period. It also works in the second trimester of pregnancy. It contains Mifepristone and Misoprostol, which blocks the effects of the progesterone hormone required in women to continue the pregnancy. Also, it increases the womb's (uterus) contraction and dilates the cervix, thereby expelling the pregnancy. In some cases, you may experience side effects such as nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Spazio Kit Tablet:
When Methylprednisolone is taken with Spazio Kit Tablet, it may decrease the levels of Methylprednisolone, which may be less effective in treating your condition.

How to manage the interaction:
Taking Methylprednisolone with Spazio Kit Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Taking Clopidogrel together with Spazio Kit Tablet increases the risk of vaginal bleeding in women.

How to manage the interaction:
Although taking clopidogrel with Spazio Kit Tablet is not recommended, that would certainly result in interaction, it can be taken if a doctor prescribes it. If you experience prolonged and heavy bleeding, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Co-administration of Betamethasone with Spazio Kit Tablet may significantly reduce the effect of Betamethasone which may be less effective as a therapy.

How to manage the interaction:
Taking betamethasone with Spazio Kit Tablet together can result in an interaction, it can be taken if a doctor has advised it. Contact a doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
Using Fluticasone furoate with Spazio Kit Tablet can reduce the effect of fluticasone furoate.

How to manage the interaction:
Taking Fluticasone furoate with Spazio Kit Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Spazio Kit Tablet:
Using Spazio Kit Tablet together with budesonide may significantly reduce the effects of budesonide.

How to manage the interaction:
Taking Budesonide with Spazio Kit Tablet is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Spazio Kit Tablet:
Co-administration of Spazio Kit Tablet and Midazolam may significantly increase Midazolam blood levels and effects, which increases the risk of side effects.

How to manage the interaction:
Although taking Spazio Kit Tablet and Midazolam together may result in an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have excessive or prolonged sleepiness and breathing issues. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
When Spazio Kit Tablet is taken with Dabigatran etexilate, it may increase the risk of severe vaginal bleeding in women.

How to manage the interaction:
Taking Spazio Kit Tablet with Dabigatran etexilate is not recommended, but it can be taken if prescribed by the doctor. However, if you experience heavy, persistent vaginal bleeding, consult the door. Do not stop using any medications without talking to a doctor.
How does the drug interact with Spazio Kit Tablet:
When Fludrocortisone is taken with Spazio Kit Tablet, it can increase the risk of side effects.

How to manage the interaction:
Taking Spazio Kit Tablet with Fludrocortisone is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medication without consulting a doctor.
How does the drug interact with Spazio Kit Tablet:
When Spazio Kit Tablet is taken with Lovastatin, it can increase the risk of side effects including rhabdomyolysis (a condition that causes your muscles to break down (disintegrate), which leads to muscle death).

How to manage the interaction:
Taking Lovastatin with Spazio Kit Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
MifepristoneLepirudin
Critical
How does the drug interact with Spazio Kit Tablet:
Co-administration of Lepirudin with Spazio Kit Tablet can increase the risk of side effects like vaginal bleeding in women.

How to manage the interaction:
Taking Spazio Kit Tablet with Lepirudin is not recommended, but it can be taken if prescribed by the doctor. However, if you experience excessive, prolonged vaginal bleeding, consult the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MG+MISOPROSTOL-200MCGFruit juices, Fruits
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consumption of grapefruit or grapefruit juice along with Spazio Kit Tablet may cause the medication's blood levels to rise to unwanted levels and raise the chance of adverse effects. Avoid taking grapefruit or grapefruit juice along with Spazio Kit Tablet as this can raise the chance of adverse effects. However, consult a doctor if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, hypokalemia (low blood potassium), fluid retention, swelling, and high blood pressure.

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