Keygraf Capsule యొక్క ఉపయోగాలు, ప్రయోజనాలు మరియు ధరను వీక్షించండి in Telugu

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Keygraf Capsule is used to prevent rejection of a transplanted organ, such as a liver, kidney, or heart. It contains Tacrolimus, which works by suppressing the activity of T and B lymphocytes (cells in the immune system) that usually attack foreign invaders and defend the body against foreign cells and infection. Thus, it prevents organ rejection in transplanted patients and helps the body to accept the new organ.

Written By Veda Maddala , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

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Side effects of Keygraf Capsule

Indigestion

Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:

Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Low Potassium Levels In Blood

Talk to your doctor about oral potassium supplements.
Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.

Loss of appetite

Low White Blood Cell Count

Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
Get sufficient sleep and manage stress which helps in improving white blood cell count.
Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.

Involuntary Shaking

Here are the steps to manage medication-triggered tremors or involuntary shaking:

Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

Burning Or Tingling Sensation

Change positions or take a break from activity to relieve symptoms.
Avoid postures that put a lot of pressure on just one area of the body.
If you have vitamin deficiency, take supplements or change your diet.
Exercise regularly like cycling, walking or swimming.
Avoid sitting with your legs crossed.
Clench and unclench your fists and wiggle your toes.
Massage the affected area.

Trouble Falling/ Staying Asleep

Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:

Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
Try relaxing techniques like deep breathing, mindfulness meditation and any others.
Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.

Have a query?

Drug-Drug Interactions

Drug-Drug Interaction: Inform your doctor if you are taking immunosuppressants (cyclosporine, sirolimus), anti-HIV drugs (nelfinavir), anticonvulsants (phenytoin), antifungals (itraconazole, ketoconazole, voriconazole), antibiotics (erythromycin, clarithromycin), diuretics (triamterene, amiloride) and other medicines.

Drug-Food Interaction: Keygraf Capsule may interact with St. John’s Wort (a herbal supplement to treat depression). Avoid taking grapefruit and grapefruit juice with Keygraf Capsule as it may cause serious side effects. Also, avoid consumption of alcohol with Keygraf Capsule .

Drug-Disease Interaction: If you have liver, kidney or heart problems, inform your doctor before taking Keygraf Capsule .

TacrolimusSaquinavir

Critical

TacrolimusDronedarone

Critical

Drug-Drug Interactions

TacrolimusSaquinavir

Critical

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with saquinavir can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf Capsule with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

TacrolimusDronedarone

Critical

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with dronedarone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf Capsule with Dronedarone is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

TacrolimusCidofovir

Critical

How does the drug interact with Keygraf Capsule:
Taking cidofovir with Keygraf Capsule can increase the risk of kidney problems.

How to manage the interaction:
Taking Keygraf Capsule with Cidofovir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor immediately if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without first talking to your doctor.

TacrolimusZiprasidone

Critical

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf Capsule with Ziprasidone together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.

TacrolimusThioridazine

Critical

How does the drug interact with Keygraf Capsule:
Combining Keygraf Capsule with Thioridazine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Keygraf Capsule with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

TacrolimusMifepristone

Critical

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with Mifepristone may significantly increase the blood levels of Keygraf Capsule, which may increase the risk and/or severity of side effects.

How to manage the interaction:
Taking Keygraf Capsule with Mifepristone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience unusual symptoms. Do not discontinue any medications without consulting a doctor.

TacrolimusGentamicin

Severe

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with gentamicin may cause kidney problems.

How to manage the interaction:
Although there is a possible interaction, gentamicin can be taken with Keygraf Capsule if prescribed by the doctor. However, consult the doctor if you experience symptoms of kidney damage such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

TacrolimusTenofovir alafenamide

Severe

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with tenofovir alafenamide will have additive effect and may increase risk of kidney problems.

How to manage the interaction:
Although taking Keygraf Capsule and tenofovir alafenamide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

TacrolimusEtodolac

Severe

How does the drug interact with Keygraf Capsule:
Taking Keygraf Capsule with etodolac may increase risk of kidney problems.

How to manage the interaction:
Although taking Keygraf Capsule and etodolac together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

TacrolimusClarithromycin

Severe

How does the drug interact with Keygraf Capsule:
Clarithromycin may boost the blood levels of Keygraf Capsule increasing the risk of kidney problems, high blood sugars, high potassium levels in the blood, high blood pressure, irregular heart rhythm, and infections.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Keygraf Capsule if prescribed by the doctor. However, consult the doctor if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

TACROLIMUS-0.25MGGrapefruit and Grapefruit Juice

Moderate

Drug-Food Interactions

TACROLIMUS-0.25MGGrapefruit and Grapefruit Juice

Moderate

Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking of grapefruit or grapefruit juice while on Keygraf Capsule treatment may lead to increased Keygraf Capsule levels in blood. Avoid or limit grapefruit or grapefruit juice intake during treatment with Keygraf Capsule.

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