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Lefra 20 Tablet 10's
Lefra 20 Tablet 10's
Lefra 20 Tablet 10's

Lefra 20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. This medicine may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Lefra 20 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Drug-Drug Interactions

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LeflunomideRituximab
Severe
LeflunomideLevamisole
Severe

Drug-Drug Interactions

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LeflunomideRituximab
Severe
How does the drug interact with Lefra 20 Tablet:
Taking Rituximab with Lefra 20 Tablet can increase the risk of infections.

How to manage the interaction:
Taking Rituximab with Lefra 20 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience fatigue, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
LeflunomideLevamisole
Severe
How does the drug interact with Lefra 20 Tablet:
When cladribine and levamisole are used together, there is a higher chance of getting serious infections.

How to manage the interaction:
There may be a possibility of interaction between Levamisole and Lefra 20 Tablet, but it can be taken if prescribed by a doctor. If you have any of these symptoms - infection, complications, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideCarfilzomib
Severe
How does the drug interact with Lefra 20 Tablet:
Combining Carfilzomib with Lefra 20 Tablet can increase the risk of negative side effects.

How to manage the interaction:
Taking Carfilzomib with Lefra 20 Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include liver damage, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or bleeding. Do not discontinue any medications without consulting your doctor.
LeflunomideCladribine
Severe
How does the drug interact with Lefra 20 Tablet:
Combining Cladribine with Lefra 20 Tablet can increase the risk of serious infections.

How to manage the interaction:
Taking Lefra 20 Tablet with Cladribine together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any complications, infections, fever, chills, diarrhoea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, it is recommended to contact your doctor right away. Do not discontinue any medications without consulting your doctor.
LeflunomideLevofloxacin
Severe
How does the drug interact with Lefra 20 Tablet:
Coadministration of Levofloxacin and Lefra 20 Tablet can increase the risk of liver issues.

How to manage the interaction:
Although concomitant administration of levofloxacin alongside Lefra 20 Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you have a fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes, contact the doctor right away. Do not discontinue any medications without consulting a doctor.
LeflunomideTemozolomide
Severe
How does the drug interact with Lefra 20 Tablet:
Taking Temozolomide with Lefra 20 Tablet can increase the risk of infections.

How to manage the interaction:
Although taking temozolomide and Lefra 20 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
LeflunomideEtanercept
Severe
How does the drug interact with Lefra 20 Tablet:
Taking Lefra 20 Tablet with etanercept may affect bone marrow functioning, resulting in a low quantity of different types of blood cells. This increases your chances of developing anemia, bleeding issues, or infections.

How to manage the interaction:
Co-administration of Etanercept with Lefra 20 Tablet can result in an interaction, but it can be taken if a doctor has advised it. If you experience paleness, exhaustion, dizziness, lightheadedness, unusual bleeding or bruising, fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, or pain or burning during urination, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
LeflunomideFlurbiprofen
Severe
How does the drug interact with Lefra 20 Tablet:
Using Flurbiprofen with Lefra 20 Tablet can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Lefra 20 Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
LeflunomideClozapine
Severe
How does the drug interact with Lefra 20 Tablet:
The combined use of Lefra 20 Tablet and clozapine may increase the risk of neutropenia (low white blood cell count)

How to manage the interaction:
There may be a possibility of interaction between Lefra 20 Tablet and Clozapine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomidePosaconazole
Severe
How does the drug interact with Lefra 20 Tablet:
Taking Lefra 20 Tablet with posaconazole can increase the risk of liver problems.

How to manage the interaction:
Although using Posaconazole and Lefra 20 Tablet together can result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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