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Regestrone 5 mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Regestrone 5 mg Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Regestrone 5 mg Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Regestrone 5 mg Tablet as it may increase the levels of Regestrone 5 mg Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Regestrone 5 mg Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Regestrone 5 mg Tablet .

Drug-Drug Interactions

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How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Dabrafenib can reduce the metabolism and decrease the levels of Regestrone 5 mg Tablet in the body.

How to manage the interaction:
Taking Regestrone 5 mg Tablet with Dabrafenib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet and Mycophenolic acid can decrease the levels and effects of Regestrone 5 mg Tablet.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Regestrone 5 mg Tablet, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Fosphenytoin can reduces the blood levels and effects of Regestrone 5 mg Tablet .

How to manage the interaction:
Taking Regestrone 5 mg Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NorethisteroneBoceprevir
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using Boceprevir and Regestrone 5 mg Tablet together can reduce the blood levels and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Boceprevir with Regestrone 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, abnormal bleeding, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Acitretin with Regestrone 5 mg Tablet may interfere with the contraceptive effect of Regestrone 5 mg Tablet.

How to manage the interaction:
Acitretin and Regestrone 5 mg Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet with Topiramate can reduce the blood levels and effects of norethindrone in the body. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Regestrone 5 mg Tablet and topiramate together can result in an interaction; it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, hot flashes or vaginal dryness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using Felbamate and Regestrone 5 mg Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Regestrone 5 mg Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Regestrone 5 mg Tablet:
The combined use of Regestrone 5 mg Tablet and phenobarbital can reduce the blood levels and effects of Regestrone 5 mg Tablet.

How to manage the interaction:
Although taking phenobarbital and Regestrone 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
NorethisteroneEtretinate
Severe
How does the drug interact with Regestrone 5 mg Tablet:
Using Etretinate and Regestrone 5 mg Tablet together can cause severe, birth defects. Never use etretinate if you are pregnant. Both a primary and a secondary form of birth control must be used together and for at least 3 years after stopping therapy.

How to manage the interaction:
Although taking Regestrone 5 mg Tablet and Etretinate together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these signs, make sure to contact your doctor right away. These symptoms may be related to your birth control. Do not stop using any medications without a doctor's advice.
How does the drug interact with Regestrone 5 mg Tablet:
Coadministration of Regestrone 5 mg Tablet and primidone can reduce the blood levels and effects of Regestrone 5 mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Regestrone 5 mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Regestrone 5 mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Regestrone 5 mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Regestrone 5 mg Tablet dose.

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