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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Smartinor 5mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Drug-Drug Interactions

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NorethisteroneBexarotene
Severe

Drug-Drug Interactions

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How does the drug interact with Smartinor 5 mg Tablet:
Taking Smartinor 5 mg Tablet with rifampicin can decrease the blood levels of Smartinor 5 mg Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Smartinor 5 mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneBexarotene
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Bexarotene and Smartinor 5 mg Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Smartinor 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Acitretin with Smartinor 5 mg Tablet may interfere with the contraceptive effect of Smartinor 5 mg Tablet.

How to manage the interaction:
Acitretin and Smartinor 5 mg Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.
How does the drug interact with Smartinor 5 mg Tablet:
Taking griseofulvin with Smartinor 5 mg Tablet may reduce blood levels and the effects of Smartinor 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Griseofulvin and Smartinor 5 mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Smartinor 5 mg Tablet with Tizanidine can cause drowsiness, confusion, slow heart rate, shallow breathing, feeling light-headed, fainting.

How to manage the interaction:
Taking Smartinor 5 mg Tablet with Tizanidine together can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NorethisteroneAmprenavir
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Amprenavir and Smartinor 5 mg Tablet together may reduce amprenavir effects.

How to manage the interaction:
Combining Amprenavir with Smartinor 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Smartinor 5 mg Tablet and primidone can reduce the blood levels and effects of Smartinor 5 mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Smartinor 5 mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneTelaprevir
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Using Telaprevir and Smartinor 5 mg Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Smartinor 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Smartinor 5 mg Tablet with Oxcarbazepine can reduce the blood levels and effects of norethindrone. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Although taking oxcarbazepine and Smartinor 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
The combined use of Smartinor 5 mg Tablet and phenobarbital can reduce the blood levels and effects of Smartinor 5 mg Tablet.

How to manage the interaction:
Although taking phenobarbital and Smartinor 5 mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Smartinor 5 mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Smartinor 5 mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Smartinor 5 mg Tablet dose.

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