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Smartinor 5mg Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Smartinor 5mg Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Smartinor 5mg Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Smartinor 5mg Tablet as it may increase the levels of Smartinor 5mg Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Smartinor 5mg Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Smartinor 5mg Tablet .

Drug-Drug Interactions

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How does the drug interact with Smartinor 5 mg Tablet:
Eslicarbazepine may reduce the effects of Smartinor 5 mg Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Smartinor 5 mg Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Using tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking Smartinor 5 mg Tablet with tranexamic acid can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Smartinor 5 mg Tablet with Fosphenytoin can reduces the blood levels and effects of Smartinor 5 mg Tablet .

How to manage the interaction:
Taking Smartinor 5 mg Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Smartinor 5 mg Tablet with Dabrafenib can reduce the metabolism and decrease the levels of Smartinor 5 mg Tablet in the body.

How to manage the interaction:
Taking Smartinor 5 mg Tablet with Dabrafenib together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of hot flashes, vaginal dryness, or abnormal bleeding, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Taking griseofulvin with Smartinor 5 mg Tablet may reduce blood levels and the effects of Smartinor 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Griseofulvin and Smartinor 5 mg Tablet, you can take these medicines together if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Coadministration of Smartinor 5 mg Tablet and primidone can reduce the blood levels and effects of Smartinor 5 mg Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Smartinor 5 mg Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneTelaprevir
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Using Telaprevir and Smartinor 5 mg Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Smartinor 5 mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Using Felbamate and Smartinor 5 mg Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Smartinor 5 mg Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosamprenavir
Severe
How does the drug interact with Smartinor 5 mg Tablet:
Using norethindrone together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Taking Smartinor 5 mg Tablet with Fosamprenavir together can result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing any symptoms, it's important to reach out to a doctor right away. They can recommend other options that won't interfere with your medication. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Smartinor 5 mg Tablet:
Taking Smartinor 5 mg Tablet with rifampicin can decrease the blood levels of Smartinor 5 mg Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Smartinor 5 mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Smartinor 5 mg Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Smartinor 5 mg Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Smartinor 5 mg Tablet dose.

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