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UNICONTIN 400MG TABLET is used for the management of asthma and chronic obstructive pulmonary disease (COPD). It contains Theophylline, which works by relaxing the airway in the lungs and making it easier to breathe. In some cases, you may experience side effects such as nausea, vomiting, restlessness, tremors, headache, muscle cramps, and increased heart rate. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Unicontin 400mg Tablet
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Maintain consistent habits, sleep patterns and food times to help maintain stability and reduce confusion.
  • Mindfulness techniques such as deep breathing or meditation help you stay focused and in the now.
  • Participate in cognitive therapy to enhance your ability to remember, focus and solve problems.
  • As directed by your physician, take your medications to help control underlying disorders like depression, anxiety or cognitive impairment.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

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Drug-Drug Interactions

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Drug-Drug Interactions: This medicine interacts with asthma or breathing medicine (aminophylline, salbutamol, terbutaline or salmeterol), oral contraceptives, antidepressant (St. John’s Wort), anticancer (aminoglutethimide, methotrexate or lomustine), high blood pressure medicine (adenosine, moracizine, diltiazem, isoprenaline, mexiletine, propafenone, propranolol, verapamil), sleeping pills (benzodiazepines), stomach ulcers medicines (cimetidine or nizatidine), antibiotics (ciprofloxacin, clarithromycin, erythromycin, norfloxacin, ofloxacin), and treat alcoholism (disulfiram).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: UNICONTIN 400MG TABLET should be taken with caution if you have high blood pressure or any other heart problems, an overactive thyroid gland (hyperthyroidism), stomach ulcer, liver problems,  seizures (fits) or convulsions, fever, viral infection, alcoholism, male and have difficulty in passing urine (due to an enlarged prostate gland).

Drug-Drug Interactions

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How does the drug interact with Unicontin 400mg Tablet:
Co-administration of Unicontin 400mg Tablet with Riociguat can increase the risk of low blood pressure.

How to manage the interaction:
Taking Unicontin 400mg Tablet with Riociguat is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, lightheadedness, fainting, flushing (a sudden reddening of the face), headache, and nasal congestion (stuffy nose). Do not discontinue any medications without consulting a doctor.
How does the drug interact with Unicontin 400mg Tablet:
Taking fluvoxamine with Unicontin 400mg Tablet may significantly increase the blood levels of Unicontin 400mg Tablet.

How to manage the interaction:
Although taking fluvoxamine and Unicontin 400mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as nausea, vomiting, diarrhea, loss of hunger, headache, shaking of hands and legs, confusion, restlessness, insomnia, fits, heart palpitations, or irregular heartbeat. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Unicontin 400mg Tablet:
Coadministration of Nebivolol with Unicontin 400mg Tablet may reduce the effect of Nebivolol.

How to manage the interaction:
Taking Nebivolol with Unicontin 400mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Unicontin 400mg Tablet:
Taking timolol with Unicontin 400mg Tablet, could make timolol less effective and enhance the effects of Unicontin 400mg Tablet.

How to manage the interaction:
Although taking timolol and Unicontin 400mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Unicontin 400mg Tablet:
Combined use of Nebivolol with Unicontin 400mg Tablet may increase the effect of Unicontin 400mg Tablet.

How to manage the interaction:
Although there is a possible interaction between Unicontin 400mg Tablet and Nebivolol, you can take these medicines together if prescribed by your doctor. However, if you experience nausea, vomiting, insomnia, tremors, restlessness, irregular heartbeats, contact a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Unicontin 400mg Tablet:
Taking sotalol with Unicontin 400mg Tablet, could reduce sotalol effects and increase the effects of Unicontin 400mg Tablet.

How to manage the interaction:
Although taking sotalol and Unicontin 400mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Unicontin 400mg Tablet:
Taking Unicontin 400mg Tablet with ciprofloxacin may increase the blood levels of Unicontin 400mg Tablet, which increases the risk of side effects.

How to manage the interaction:
Although taking ciprofloxacin and Unicontin 400mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, if you experience nausea, vomiting, diarrhea, lack of appetite, headache, tremor(shaking of hands & legs), confusion, restlessness, sleeplessness, seizures(fits), irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
TheophyllinePindolol
Severe
How does the drug interact with Unicontin 400mg Tablet:
Taking pindolol with Unicontin 400mg Tablet, could make pindolol less effective and increase the effects of Unicontin 400mg Tablet.

How to manage the interaction:
Although taking pinolol and Unicontin 400mg Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Unicontin 400mg Tablet:
Taking Metoprolol Succinate with Unicontin 400mg Tablet, could make Metoprolol Succinate less effective and enhance the effects of Unicontin 400mg Tablet.

How to manage the interaction:
Although taking metoprolol succinate and Unicontin 400mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, shaking of hands and legs, restlessness, uneven heartbeats, or difficulty breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Unicontin 400mg Tablet:
Taking Labetalol with Unicontin 400mg Tablet may reduce the effectiveness of Labetalol and increase Unicontin 400mg Tablet's effects.

How to manage the interaction:
Although taking Labetalol and Unicontin 400mg Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience sleeplessness, shaking, irregular heartbeats, or trouble breathing, consult a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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THEOPHYLLINE-400MGCaffeine containing foods/drinks
Moderate

Drug-Food Interactions

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THEOPHYLLINE-400MGCaffeine containing foods/drinks
Moderate
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Caffeine consumption can modify Unicontin 400mg Tablet blood levels. Caffeine should be avoided in excess while using Unicontin 400mg Tablet. Consult a doctor if you suffer any symptoms such as headaches, sleeplessness, or increases in blood pressure or heart rate. Do not discontinue any medications without consulting a doctor.

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