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Arpimune ME 50 Tablet 5's
Arpimune ME 50 Tablet 5's

Arpimune ME 50 Tablet is used to prevent organ transplant rejection. It is also used to treat inflammation and pain associated with psoriasis and rheumatoid arthritis. This medicine contains cyclosporine, which works by suppressing the immune system. It also helps reduce rapid skin cell growth, pain, and inflammation. It may sometimes cause common side effects such as headaches, vomiting, nausea, loss of appetite, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Arpimune ME 50 Tablet
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
CiclosporinSimvastatin
Critical

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
How does the drug interact with Arpimune ME 50 Tablet:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Arpimune ME 50 Tablet with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinSimvastatin
Critical
How does the drug interact with Arpimune ME 50 Tablet:
Combining Arpimune ME 50 Tablet and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Arpimune ME 50 Tablet and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBosentan
Critical
How does the drug interact with Arpimune ME 50 Tablet:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Arpimune ME 50 Tablet with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinPitavastatin
Critical
How does the drug interact with Arpimune ME 50 Tablet:
Coadministration of pitavastatin with Arpimune ME 50 Tablet may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Arpimune ME 50 Tablet is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinCidofovir
Critical
How does the drug interact with Arpimune ME 50 Tablet:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Arpimune ME 50 Tablet with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinRitonavir
Severe
How does the drug interact with Arpimune ME 50 Tablet:
Taking Arpimune ME 50 Tablet with ritonavir may significantly increases the blood levels of Arpimune ME 50 Tablet.

How to manage the interaction:
Taking ritonavir with Arpimune ME 50 Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loose stools, abdominal pain, dizziness, weakness, headache, fits, shaking, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination, contact a doctor. Do not stop using any medications without talking to a doctor.
CiclosporinColchicine
Severe
How does the drug interact with Arpimune ME 50 Tablet:
Co-administration of colchicine with Arpimune ME 50 Tablet may increases the blood levels and effects of both medications.

How to manage the interaction:
Although there is a possible interaction between colchicine and Arpimune ME 50 Tablet, you can take these medicines together if prescribed by your doctor. However, contact a doctor immediately if you experience any symptoms such as abdominal pain, diarrhoea, fever, muscle pain, weakness, and numbness or tingling in your hands and feet. Do not discontinue any medications without consulting a doctor.
CiclosporinTenofovir alafenamide
Severe
How does the drug interact with Arpimune ME 50 Tablet:
Co-administration of tenofovir alafenamide with Arpimune ME 50 Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction, tenofovir alafenamide can be taken with Arpimune ME 50 Tablet if prescribed by the doctor. However, consult the doctor if you experience side effects such as diarrhea, nausea, vomiting, abdominal pain, dizziness, weakness, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, and increased or decreased urination. Do not discontinue the medication without a doctor's advice.
CiclosporinLovastatin
Severe
How does the drug interact with Arpimune ME 50 Tablet:
Co-administration of lovastatin with Arpimune ME 50 Tablet may significantly increase the blood levels of lovastatin. This can raise the chance of side effects such as liver injury and rhabdomyolysis, an uncommon but serious illness that causes the breakdown of skeletal muscle tissue. Rhabdomyolysis occasionally results in kidney injury.

How to manage the interaction:
Although taking lovastatin with cyclosporine together can possibly result in an interaction, they can be taken if your doctor has prescribed it. However, if you experience muscle pain, tenderness, or weakness especially accompanied by fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, light colored stools, and/or yellowing of the skin or eyes, you should consult the doctor.
CiclosporinOrlistat
Severe
How does the drug interact with Arpimune ME 50 Tablet:
Coadministration of Arpimune ME 50 Tablet with Orlistat can reduce the levels and effects of Arpimune ME 50 Tablet.

How to manage the interaction:
Although there is a possible interaction between Orlistat and Arpimune ME 50 Tablet, you can take these medicines together when prescribed by your doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Arpimune ME 50 Tablet can increase the effects of Arpimune ME 50 Tablet. Avoid consuming grapefruit and grapefruit juice while taking Arpimune ME 50 Tablet.

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