BOSENTAN is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). BOSENTAN can even increase our exercising ability, delay disease progression, and improve quality of life. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart.
BOSENTAN contains Bosentan, and an endothelin receptor antagonist used to treat pulmonary arterial hypertension. It works by blocking the action of endothelin. Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. BOSENTAN helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.
Take BOSENTAN as prescribed by your doctor. You are advised to take BOSENTAN for as long as your doctor has prescribed it for you, depending upon your medical condition. You may experience swelling of legs and ankles, headaches, and diarrhoea in some cases. Most of these side effects of BOSENTAN do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor. Some rare cases may cause anaemia and abnormal liver function such as nausea, vomiting, dark urine, and fever, which your doctor should know.
Please inform your doctor if you have liver dysfunction before starting BOSENTAN. If you are pregnant or breastfeeding, do not take BOSENTAN a pregnancy category X drug. If you are taking BOSENTAN, women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping BOSENTAN. Also, the blood test for liver functions should be monitored regularly and for haemoglobin level.
Pulmonary arterial hypertension (PAH)
BOSENTAN is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). BOSENTAN can even increase our exercising ability, delay disease progression, and improve quality of life. It works by blocking the action of endothelin. Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. BOSENTAN helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs. It also improves the quality of life, exercising ability, and delays the progression of pulmonary arterial hypertension.
Do not take BOSENTAN if you are allergic to BOSENTAN or any of its ingredients. Please inform your doctor if you have liver dysfunction before starting BOSENTAN. If you are pregnant or breastfeeding, do not take BOSENTAN as it is a pregnancy category X drug. It can lead to defects in the baby if taken during pregnancy. Also, after stoping BOSENTAN at least after a gap of one month, you should try to conceive so that BOSENTAN flushed out of body completely. If you are taking BOSENTAN, women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping BOSENTAN. Blood tests for liver functions should be monitored regularly and for hemoglobin level as well. As low hemoglobin could be a sign of anemia.
Drug-Drug Interaction: BOSENTAN is known to interact with anti-hypertensive medicines (amiodarone), cholesterol-lowering medications (atorvastatin, lovastatin, simvastatin), antibiotics (erythromycin, rifampin), anti-fungal (fluconazole, itraconazole, ketoconazole), anti-viral (ritonavir), blood thinner (warfarin), immune suppression medicines (cyclosporine), anti-diabetic (glibenclamide), and medicines to treat erectile dysfunction (sildenafil, tadalafil).
Drug-Food Interaction: BOSENTAN is known to interact with grapefruit juice.
Drug-Disease Interaction: BOSENTAN is known to interact if you have liver disease, anaemia, cardiovascular disease and fluid retention.
BOSENTAN should not be taken along with alcohol to avoid unpleasant side effects.
BOSENTAN is a category X pregnancy drug and it can cause harm to the baby, so it should not be taken if you are pregnant or planning to get pregnant.
BOSENTAN is known to pass through breast milk and may cause harm to the baby, so it should not be taken if you are breastfeeding.
BOSENTAN may cause hypotension (low blood pressure), which may make you feel dizzy. If you feel dizzy, please do not drive a car.
BOSENTAN to be taken with caution, especially if you have or have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
BOSENTAN to be taken with caution, especially if you have or have had a kidney disease history. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.
BOSENTAN is not recommended for use in children.
, ,Pulmonary arterial hypertension (PAH): High pressure in the blood vessels that carry blood from the heart to the lungs. It can be due to constriction of blood vessels or some blockage in blood vessels' pathway.