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CORVELA TABLET

CORVELA TABLET is used alone or with other medicines to treat angina pectoris. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines. In some cases, it may cause side effects such as constipation, dizziness, headache, or feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Corvela Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Drug-Drug Interactions

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RanolazineRifampicin
Critical
RanolazineTroglitazone
Critical

Drug-Drug Interactions

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RanolazineRifampicin
Critical
How does the drug interact with Corvela Tablet:
When Corvela Tablet is taken with rifampicin, it can reduce the blood levels and effects of Corvela Tablet.

How to manage the interaction:
Although there is an interaction between Corvela Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazineTroglitazone
Critical
How does the drug interact with Corvela Tablet:
Co-administration of Troglitazone with Corvela Tablet may significantly reduce blood levels of Corvela Tablet.

How to manage the interaction:
Taking Corvela Tablet with Troglitazone together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RanolazineMifepristone
Critical
How does the drug interact with Corvela Tablet:
When Mifepristone is taken with Corvela Tablet, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Corvela Tablet can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineRifapentine
Critical
How does the drug interact with Corvela Tablet:
When Corvela Tablet is taken with Rifapentine, may significantly reduce the blood levels of Corvela Tablet.

How to manage the interaction:
Taking Corvela Tablet with Rifapentine together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
RanolazineRifabutin
Critical
How does the drug interact with Corvela Tablet:
Taking Rifabutin and Corvela Tablet may significantly reduce the blood levels of Corvela Tablet.

How to manage the interaction:
There may be a possibility of interaction between Rifabutin and Corvela Tablet, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
RanolazineNafcillin
Critical
How does the drug interact with Corvela Tablet:
When Nafcillin is taken with Corvela Tablet, may significantly reduce the blood levels of Corvela Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Nafcillin with Corvela Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. Do not stop taking any medications without consulting a doctor.
RanolazineCarbamazepine
Critical
How does the drug interact with Corvela Tablet:
Taking Corvela Tablet with carbamazepine may significantly reduce the blood levels of Corvela Tablet, which may make the medication ineffective or less effective.

How to manage the interaction:
Taking Corvela Tablet with Carbamazepine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
RanolazineCeritinib
Critical
How does the drug interact with Corvela Tablet:
When Ceritinib is taken with Corvela Tablet, may significantly increase the blood levels and effects of Corvela Tablet.

How to manage the interaction:
Taking Corvela Tablet with Ceritinib together can possibly result in an interaction, but it can be taken if a doctor has advised it. In case you experience any side effects like lightheadedness, fainting, dizziness, or fast or pounding heartbeats, consult a doctor. Do not discontinue any medications without consulting a doctor.
RanolazinePhenytoin
Critical
How does the drug interact with Corvela Tablet:
Using Corvela Tablet together with phenytoin may significantly reduce the blood levels of Corvela Tablet leading to dreceased effectiveness of Corvela Tablet in treating your condition.

How to manage the interaction:
Taking Phenytoin with Corvela Tablet is not recommended. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
RanolazineEnzalutamide
Critical
How does the drug interact with Corvela Tablet:
Taking Enzalutamide may decrease the blood levels of Corvela Tablet, which may make Corvela Tablet less effective.

How to manage the interaction:
Taking Enzalutamide with Corvela Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Corvela Tablet, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Corvela Tablet if possible.

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