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  3. Divalio 500 Tablet ER

Divalio 500 Tablet ER, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Divalio 500 Tablet ER is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Side effects of Divalio 500 Tablet ER
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat eggs for zinc and other nutrients that support healthy vision.
  • Consume blueberries as antioxidants to combat eye strain.
  • Include broccoli in your diet for diverse eye-boosting nutrients.
  • Eat sweet potatoes as a natural source of vitamin A.
  • Snack on almonds for vitamin E and eye protection.
  • Add tomatoes to your diet for lycopene and vision protection.
  • Perform exercises that improve binocular vision, such as dot-to-dot cards, coloring within lines, and Brock string tests.
  • Wear an eye patch and perform tasks like playing games and solving puzzles.
  • Patching and eye exercises can improve symptoms.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Drug-Drug Interactions

verifiedApollotooltip
DivalproexGlycerol phenylbutyrate
Critical
DivalproexKetoconazole
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Divalio 500 Tablet ER:
Coadministration of Glycerol phenylbutyrate and Divalio 500 Tablet ER can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Divalio 500 Tablet ER together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexKetoconazole
Severe
How does the drug interact with Divalio 500 Tablet ER:
Coadministration of Ketoconazole and Divalio 500 Tablet ER may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Divalio 500 Tablet ER together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexMeropenem
Severe
How does the drug interact with Divalio 500 Tablet ER:
Co-administration of Divalio 500 Tablet ER and Meropenem can reduce the blood levels of Divalio 500 Tablet ER sodium.

How to manage the interaction:
Co-administration of Divalio 500 Tablet ER with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Divalio 500 Tablet ER:
Coadministration of Esketamine and Divalio 500 Tablet ER can increase the side effects of esketamine.

How to manage the interaction:
Although taking Divalio 500 Tablet ER and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexErtapenem
Severe
How does the drug interact with Divalio 500 Tablet ER:
Coadministration of Ertapenem with Divalio 500 Tablet ER may reduce the blood levels of Divalio 500 Tablet ER and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Divalio 500 Tablet ER if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
DivalproexBuprenorphine
Severe
How does the drug interact with Divalio 500 Tablet ER:
Co-administration of buprenorphine with Divalio 500 Tablet ER may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Divalio 500 Tablet ER can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Divalio 500 Tablet ER:
Co-administration of Sodium oxybate and Divalio 500 Tablet ER can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Divalio 500 Tablet ER can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexTeriflunomide
Severe
How does the drug interact with Divalio 500 Tablet ER:
Co-administration of Divalio 500 Tablet ER and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divalio 500 Tablet ER and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexVorinostat
Severe
How does the drug interact with Divalio 500 Tablet ER:
Coadministration of Divalio 500 Tablet ER and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Divalio 500 Tablet ER and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexLomitapide
Severe
How does the drug interact with Divalio 500 Tablet ER:
Co-administration of Divalio 500 Tablet ER and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divalio 500 Tablet ER and lomitapide can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like fever, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, or yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without the doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 22, 2025 | 11:25 AM IST

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