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Depakote 500 Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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Drug-Drug Interactions

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Drug-Drug Interactions: Inform your doctor if you are taking pain killers (aspirin), anti-epileptics (pregabalin, topiramate, phenobarbital, primidone, phenytoin, carbamazepine, lamotrigine, felbamate, ethosuximide), anti-HIV (zidovudine), anti-depressant (duloxetine, escitalopram, amitriptyline, nortriptyline), anti-psychotic (aripiprazole, lurasidone, quetiapine), anti-anxiety (alprazolam), anti-TB (rifampicin), anti-coagulant (warfarin), antibiotics (imipenem, meropenem), and benzodiazepine (diazepam).

Drug-Food Interactions: Avoid alcohol consumption while taking Depakote 500 Tablet , as it might cause increased dizziness and sleepiness. Alcohol intake might also provoke seizures.

Drug-Disease Interactions: Inform your doctor if you have disease conditions such as depression, liver disease, urea cycle disorders, suicidal tendency, HIV disease, and thrombocytopenia (low levels of platelets).

DivalproexGlycerol phenylbutyrate
Critical

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Depakote 500 Tablet:
Coadministration of Glycerol phenylbutyrate and Depakote 500 Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Depakote 500 Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Depakote 500 Tablet:
Co-administration of Depakote 500 Tablet and Doripenem can reduce the blood levels of Depakote 500 Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Depakote 500 Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexMipomersen
Severe
How does the drug interact with Depakote 500 Tablet:
Co-administration of Depakote 500 Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Depakote 500 Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
How does the drug interact with Depakote 500 Tablet:
Co-administration of Depakote 500 Tablet and Meropenem can reduce the blood levels of Depakote 500 Tablet sodium.

How to manage the interaction:
Co-administration of Depakote 500 Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Depakote 500 Tablet:
Coadministration of Ertapenem with Depakote 500 Tablet may reduce the blood levels of Depakote 500 Tablet and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Depakote 500 Tablet if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
How does the drug interact with Depakote 500 Tablet:
Co-administration of Depakote 500 Tablet and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Depakote 500 Tablet and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Depakote 500 Tablet:
Co-administration of Depakote 500 Tablet and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Depakote 500 Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Depakote 500 Tablet:
Co-administration of Sodium phenylbutyrate and Depakote 500 Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Depakote 500 Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Depakote 500 Tablet:
Co-administration of Depakote 500 Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Depakote 500 Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Depakote 500 Tablet:
Co-administration of buprenorphine with Depakote 500 Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Depakote 500 Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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