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Evergraf 0.5 Tablet is used to treat cancer and to prevent organ rejection. It contains Everolimus which works by stopping cancer cells from reproducing and decreasing the activity of the immune system. In some cases, this medicine may cause side effects such as weakness, infection, cough, diarrhoea, fever, and fatigue. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Evergraf 0.5 Tablet
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Evergraf 0.5 Tablet:
When Evergraf 0.5 Tablet is taken with Efavirenz, the effect of Evergraf 0.5 Tablet is reduced.

How to manage the interaction:
Co-administration of Evergraf 0.5 Tablet with Efavirenz can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Evergraf 0.5 Tablet:
Co-administration of Evergraf 0.5 Tablet and Imatinib may significantly increase the blood levels of Evergraf 0.5 Tablet. This may increase the severity of side effects (bleeding, infection, mouth ulcers, anemia, or pneumonitis - lung inflammation).

How to manage the interaction:
Taking Evergraf 0.5 Tablet with Imatinib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any unusual symptoms, consult a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Evergraf 0.5 Tablet:
Taking clarithromycin with Evergraf 0.5 Tablet may increase the blood levels of Evergraf 0.5 Tablet, which might make you more likely to develop serious side effects (pneumonitis - inflammation of the lungs, mouth ulcers, infection, anemia, or bleeding).

How to manage the interaction:
Although taking clarithromycin and Evergraf 0.5 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Evergraf 0.5 Tablet:
Taking Evergraf 0.5 Tablet with diltiazem can considerably raise blood levels of Evergraf 0.5 Tablet, increasing the risk of serious side effects such as pneumonitis (lung inflammation), infection, mouth ulcers, anemia, or bleeding.

How to manage the interaction:
Although there is a possible interaction between Diltiazem and Evergraf 0.5 Tablet, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Evergraf 0.5 Tablet:
Coadministration of Amphotericin b and Evergraf 0.5 Tablet can increase the risk of kidney problems.

How to manage the interaction:
Taking Amphotericin b with Evergraf 0.5 Tablet together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Evergraf 0.5 Tablet:
Co-administration of Evergraf 0.5 Tablet with ceritinib can raise the blood levels of Evergraf 0.5 Tablet.

How to manage the interaction:
Although there is an interaction between Ceritinib and Evergraf 0.5 Tablet, but it can be taken if prescribed by a doctor. However, if you experience any unusual symptoms like persistent cough, fever, chills, mouth ulcers, paleness, mouth sores, bruising, blood in stools, urine and vomitus, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EverolimusFenoprofen
Severe
How does the drug interact with Evergraf 0.5 Tablet:
Evergraf 0.5 Tablet can cause kidney issues, and taking it with Fenoprofen, can enhance the risk.

How to manage the interaction:
Taking Evergraf 0.5 Tablet with Fenoprofen together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Evergraf 0.5 Tablet:
Taking Evergraf 0.5 Tablet with cyclosporine may significantly increases the blood levels of Evergraf 0.5 Tablet.

How to manage the interaction:
Although taking Evergraf 0.5 Tablet and ciclosporin together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience any unusual symptoms contact a doctor immediately. In case you experience any side effects like persistent cough, fever, chills, mouth ulcers, paleness of skin, or unusual bleeding or bruising, or blood in stools or urine, consult a doctor. Do not stop using any medications without talking to a doctor.
EverolimusIopamidol
Severe
How does the drug interact with Evergraf 0.5 Tablet:
Injections of iopamidol and related contrast agents can occasionally cause kidney damage and mixing it with Evergraf 0.5 Tablet, may enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Evergraf 0.5 Tablet and Iopamidol, but it can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor immediately. Drink lots of fluid after the procedure to stay hydrated and to flush the contrast agent out of your kidneys. Do not stop using any medications without talking to a doctor.
How does the drug interact with Evergraf 0.5 Tablet:
Taking Lithium with Evergraf 0.5 Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although taking Evergraf 0.5 Tablet and Lithium together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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EVEROLIMUS-0.5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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EVEROLIMUS-0.5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Taking Evergraf 0.5 Tablet with grapefruit juice can raise blood levels and enhance the effects of Evergraf 0.5 Tablet. Since the co-administration of Evergraf 0.5 Tablet along with grapefruit juice can lead to an interaction, You should not consume grapefruit juice or eat grapefruits while taking Evergraf 0.5 Tablet.

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