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Gynaset-CR 10 Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Gynaset-CR 10 Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Gynaset-CR 10 Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Gynaset-CR 10 Tablet as it may increase the levels of Gynaset-CR 10 Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Gynaset-CR 10 Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Gynaset-CR 10 Tablet .

NorethisteroneTelaprevir
Severe

Drug-Drug Interactions

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NorethisteroneTelaprevir
Severe
How does the drug interact with Gynaset-CR 10 Tablet:
Using Telaprevir and Gynaset-CR 10 Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Gynaset-CR 10 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gynaset-CR 10 Tablet:
Co-administration of Gynaset-CR 10 Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Gynaset-CR 10 Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Gynaset-CR 10 Tablet:
Coadministration of Acitretin with Gynaset-CR 10 Tablet may interfere with the contraceptive effect of Gynaset-CR 10 Tablet.

How to manage the interaction:
Acitretin and Gynaset-CR 10 Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.
NorethisteroneBexarotene
Severe
How does the drug interact with Gynaset-CR 10 Tablet:
Coadministration of Bexarotene and Gynaset-CR 10 Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Gynaset-CR 10 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gynaset-CR 10 Tablet:
Coadministration of Phenytoin and Gynaset-CR 10 Tablet may decrease the blood levels of Gynaset-CR 10 Tablet, which may make Gynaset-CR 10 Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Gynaset-CR 10 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Gynaset-CR 10 Tablet:
Using Felbamate and Gynaset-CR 10 Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Gynaset-CR 10 Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gynaset-CR 10 Tablet:
Taking Gynaset-CR 10 Tablet with rifampicin can decrease the blood levels of Gynaset-CR 10 Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Gynaset-CR 10 Tablet and rifampicin, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneRifapentine
Severe
How does the drug interact with Gynaset-CR 10 Tablet:
Combining Rifapentine and norethindrone reduces the blood levels and effects of norethindrone and increases the risk of bleeding and unintended pregnancy.

How to manage the interaction:
Although there is a possible interaction between Gynaset-CR 10 Tablet and Rifapentine, you can take these medicines together if prescribed by your doctor. If you're having any of these symptoms like unexpected bleeding, abnormal bleeding, it's important to reach out to a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Gynaset-CR 10 Tablet:
Eslicarbazepine may reduce the effects of Gynaset-CR 10 Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Gynaset-CR 10 Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Gynaset-CR 10 Tablet:
Coadministration of Gynaset-CR 10 Tablet with Fosphenytoin can reduces the blood levels and effects of Gynaset-CR 10 Tablet .

How to manage the interaction:
Taking Gynaset-CR 10 Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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NORETHISTERONE-10MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-10MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Gynaset-CR 10 Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Gynaset-CR 10 Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Gynaset-CR 10 Tablet dose.

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