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Jakavi 5 mg Tablet 10's
Jakavi 5 mg Tablet 10's
Jakavi 5 mg Tablet 10's

Jakavi 5 mg Tablet is used in the treatment of myelofibrosis (cancer of bone marrow), polycythaemia vera (cancer of the blood), and graft-versus-host disease (GVHD, a complication of hematopoietic stem-cell transplant). It contains Ruxolitinib, which works by blocking the signals that cause cancer cells to multiply. Thereby, it helps treat myelofibrosis and polycythaemia vera. It also helps treat graft-versus-host disease by blocking the signals of the cells that cause GVHD.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Jakavi 5 mg Tablet
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Eat more plant based foods like vegetables, fruits and whole grains.
  • Reduce intake of foods containing high fat such as dairy, oil and red meat.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking.
  • Control blood sugar and blood pressure.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

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Drug-Drug Interactions

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RuxolitinibDelavirdine
Severe
RuxolitinibEnoxaparin
Severe

Drug-Drug Interactions

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RuxolitinibDelavirdine
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and Delavirdine may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Delavirdine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, weakness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Do not stop using any medications without consulting a doctor.
RuxolitinibEnoxaparin
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking enoxaparin with Jakavi 5 mg Tablet can increase the risk or severity of bleeding.

How to manage the interaction:
Taking Enoxaparin with Jakavi 5 mg Tablet together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any symptoms like bleeding, bruising, dizziness, severe headaches, black or tarry stools, weakness, and vomiting other symptoms to watch out for include black or tarry stools, weakness, and vomiting. Do not discontinue any medications without consulting a doctor.
RuxolitinibTelaprevir
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and Telaprevir may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Telaprevir together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Do not stop using any medications without consulting doctor.
RuxolitinibClozapine
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Co-administration of clozapine with Jakavi 5 mg Tablet may increase the risk of side effects.

How to manage the interaction:
Although taking Clozapine and Jakavi 5 mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience fever, chills, sore throat, or muscle aches, pain while urinating, or difficulty breathing. Do not discontinue any medications without consulting a doctor.
RuxolitinibFluconazole
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Co-administration of Jakavi 5 mg Tablet with Fluconazole may increase the blood levels of Jakavi 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, Fluconazole can be taken with Jakavi 5 mg Tablet if prescribed by the doctor. Consult the doctor if you experience signs and symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches, or other flu-like symptoms. Do not discontinue the medications without consulting a doctor.
RuxolitinibDeferiprone
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet with Deferiprone may increase the risk of developing the infections.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Deferiprone together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
RuxolitinibClarithromycin
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Clarithromycin may boost the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although there is a possible interaction, clarithromycin can be taken with Jakavi 5 mg Tablet if prescribed by the doctor. Consult the prescriber if you experience paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, or body pains. Do not stop using any medications without a doctor's advice.
RuxolitinibIndinavir
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and Indinavir may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Indinavir together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Do not stop using any medications without consulting doctor.
RuxolitinibMibefradil
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet and Mibefradil may increase the blood levels and effects of Jakavi 5 mg Tablet.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Mibefradil together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as paleness, tiredness, dizziness, fainting, unusual bleeding or bruising, fever, chills, sore throat, body aches. Do not stop using any medications without consulting doctor.
RuxolitinibAdalimumab
Severe
How does the drug interact with Jakavi 5 mg Tablet:
Taking Jakavi 5 mg Tablet together with Adalimumab may increase the risk of infections.

How to manage the interaction:
Although taking Jakavi 5 mg Tablet and Adalimumab together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.

Drug-Food Interactions

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RUXOLITINIB-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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RUXOLITINIB-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking Grape fruit or grapefruit juice with Jakavi 5 mg Tablet may increase the blood levels of Jakavi 5 mg Tablet. Although there is a possible interaction, Jakavi 5 mg Tablet can be taken if prescribed by a doctor. Contact a doctor if you have any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bleeding or bruises, fever, chills, sore throat, body pains, or other flu-like symptoms. Do not stop taking the medication without consulting a doctor.

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