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Mendate 15 Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Mendate 15 Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug-Food Interaction: Mendate 15 Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Mendate 15 Tablet as it may increase the levels of Mendate 15 Tablet in the blood.  

Drug-Disease Interactions: Avoid taking Mendate 15 Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Mendate 15 Tablet.

Drug-Drug Interactions

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How does the drug interact with Mendate 15 Tablet:
Coadministration of Phenytoin and Mendate 15 Tablet may decrease the blood levels of Mendate 15 Tablet, which may make Mendate 15 Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Mendate 15 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mendate 15 Tablet:
Co-administration of Mendate 15 Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Mendate 15 Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Mendate 15 Tablet:
The combined use of Mendate 15 Tablet and phenobarbital can reduce the blood levels and effects of Mendate 15 Tablet.

How to manage the interaction:
Although taking phenobarbital and Mendate 15 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
NorethisteroneAmprenavir
Severe
How does the drug interact with Mendate 15 Tablet:
Coadministration of Amprenavir and Mendate 15 Tablet together may reduce amprenavir effects.

How to manage the interaction:
Combining Amprenavir with Mendate 15 Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mendate 15 Tablet:
Coadministration of Mendate 15 Tablet and Mycophenolic acid can decrease the levels and effects of Mendate 15 Tablet.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Mendate 15 Tablet, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
NorethisteroneTelaprevir
Severe
How does the drug interact with Mendate 15 Tablet:
Using Telaprevir and Mendate 15 Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Mendate 15 Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mendate 15 Tablet:
Taking carbamazepine and Mendate 15 Tablet may possibly reduce the effects of Mendate 15 Tablet which may result in higher risk of breakthrough bleeding and unexpected pregnancy.

How to manage the interaction:
Although taking carbamazepine and Mendate 15 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. Contact your doctor if you experience hot flashes, vaginal dryness, or uncontrolled bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mendate 15 Tablet:
Coadministration of Mendate 15 Tablet and primidone can reduce the blood levels and effects of Mendate 15 Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Mendate 15 Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Mendate 15 Tablet:
Coadministration of Mendate 15 Tablet with Fosphenytoin can reduces the blood levels and effects of Mendate 15 Tablet .

How to manage the interaction:
Taking Mendate 15 Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mendate 15 Tablet:
Coadministration of Mendate 15 Tablet with Oxcarbazepine can reduce the blood levels and effects of norethindrone. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Although taking oxcarbazepine and Mendate 15 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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