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MIFEPRIN TABLET

MIFEPRIN TABLET is used in combination with Misoprostol to induce a medical abortion. It is primarily used to end an early pregnancy (lasting up to 70 days or less than this) or an unwanted pregnancy with medication help. It contains Mifepristone, which works by blocking the effect of progesterone (female hormone), needed to sustain a pregnancy. In some cases, you may experience side effects such as nausea, uterine cramps, vomiting, diarrhoea, infection following abortion, dizziness, and uterine bleeding. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Veda Maddala , M Pharmacy
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Side effects of Mifeprin Tablet
  • Your doctor may reduce your medication dose gradually if you have too much cortisol, while still managing your condition.
  • Try hot baths, massages, and gentle exercises like water aerobics or tai chi to ease aches and pains.
  • Limit sodium and fatty foods to reduce health risks.
  • Consume foods rich in calcium, like dairy, leafy greens, fortified plant milk, and salmon, to support bone health.
  • Include sources of vitamin D in your meals, such as cod liver oil, egg yolks, fortified milk, and fatty fish like swordfish and salmon.
  • Make time for things you enjoy and set limits to avoid getting too tired.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Consume more protein-rich foods and healthy fats like beans, avocados, cheese, nuts and lean meats to minimize appetite.
  • Prefer foods high in fiber to help feel full for a long time.
  • If you have decreased appetite, eat only when you are hungry.
  • Eat several small meals or snacks all day.
  • Try to take only small sips of fluids while eating.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Drug-Drug Interactions

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MifepristoneProtamine
Critical
MifepristoneRanolazine
Critical

Drug-Drug Interactions

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MifepristoneProtamine
Critical
How does the drug interact with Mifeprin Tablet:
Taking Protamine and Mifeprin Tablet increases the risk of bleeding in post-abortion patients.

How to manage the interaction:
Taking protamine with Mifeprin Tablet together results in an interaction, but they can be taken together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
MifepristoneRanolazine
Critical
How does the drug interact with Mifeprin Tablet:
When Mifeprin Tablet is taken with Ranolazine, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Ranolazine can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
MifepristoneFluticasone
Critical
How does the drug interact with Mifeprin Tablet:
Co-administration of Fluticasone with Mifeprin Tablet may make Fluticasone less effective as a therapy.

How to manage the interaction:
Taking Fluticasone with Mifeprin Tablet is not recommended, consult a doctor before taking it. Do not stop using any medications without talking to a doctor.
MifepristoneSirolimus
Critical
How does the drug interact with Mifeprin Tablet:
Coadministration of Sirolimus with Mifeprin Tablet can increase the levels of Sirolimus in the blood, which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Sirolimus with Mifeprin Tablet is not recommended, they can be taken together if a doctor advises. However, contact a doctor if you experience any symptoms like back pain · difficulty falling asleep or staying asleep, fever, headache, joint pain, rash, stomach pain, constipation, or diarrhea. Do not stop taking any medications without consulting a doctor.
MifepristoneMethylprednisolone
Critical
How does the drug interact with Mifeprin Tablet:
When Methylprednisolone is taken with Mifeprin Tablet, it may decrease the levels of Methylprednisolone, which may be less effective in treating your condition.

How to manage the interaction:
Taking Methylprednisolone with Mifeprin Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MifepristoneFentanyl
Critical
How does the drug interact with Mifeprin Tablet:
Taking fentanyl and Mifeprin Tablet may significantly increase the blood levels of fentanyl, which may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Mifeprin Tablet and fentanyl, they can be taken together if advised by a doctor. Do not stop using any medications without talking to your doctor.
MifepristoneHeparin
Critical
How does the drug interact with Mifeprin Tablet:
Taking Mifeprin Tablet with Heparin can increase the risk of negative side effects.

How to manage the interaction:
Taking Heparin with Mifeprin Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without a doctor's advice.
MifepristoneBeclometasone
Critical
How does the drug interact with Mifeprin Tablet:
Co-administration of Beclomethasone dipropionate with Mifeprin Tablet may make it less effective as a therapy.

How to manage the interaction:
Taking Beclomethasone with Mifeprin Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not discontinue any medication without consulting a doctor.
MifepristoneLurasidone
Critical
How does the drug interact with Mifeprin Tablet:
Coadministration of Lurasidone with Mifeprin Tablet can increase the levels of Lurasidone which can increase the risk or severity of side effects.

How to manage the interaction:
Taking Lurasidone with Mifeprin Tablet together is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any abnormal muscle movements, seizures(fits), high blood sugar, dizziness, lightheadedness, headache, flushing, fainting, and heart palpitations, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
MifepristoneErgotamine
Critical
How does the drug interact with Mifeprin Tablet:
When Mifeprin Tablet is taken with Ergotamine, it may increase the blood levels of Ergotamine, which may result in side effects.

How to manage the interaction:
Taking Ergotamine with Mifeprin Tablet is not recommended, but it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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MIFEPRISTONE-200MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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MIFEPRISTONE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Grapefruit juice may increase the effects of Mifeprin Tablet. Avoid consumption of grape juice while taking Mifeprin Tablet. However, if you experience headache, dizziness, fatigue, nausea, vomiting, cramping, diarrhea, swelling, and high blood pressure, consult the doctor.

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Author Details

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Nov 18, 2025 | 7:32 AM IST

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