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Normonal CR Tablet is used in the treatment of heavy, painful or irregular periods, premenstrual syndrome (PMS), endometriosis and breast cancer. This medicine contains norethisterone, which works by mimicking the activity of the natural hormone progesterone, thereby restoring hormone levels in the body and helping treat menstrual problems.

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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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Drug-Drug Interactions

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Drug-Drug Interaction: Normonal CR Tablet may interact with anticonvulsants (carbamazepine, phenytoin), antiviral drugs (nelfinavir, ritonavir), a medicine used to treat Cushing’s syndrome (aminoglutethimide), antibiotics (co-trimoxazole, rifampicin, tetracycline), immunosuppressant (ciclosporin).

Drug- Food Interaction: Normonal CR Tablet may interact with St. John’s wort (herbal medicine used to treat depression). Also, limit the intake of grapefruit juice with Normonal CR Tablet as it may increase the levels of Normonal CR Tablet in blood.  

Drug-Disease Interaction: Avoid taking Normonal CR Tablet if you have vaginal bleeding, blood clots, severe itching, porphyria (blood disorder), liver problems, angina (chest pain), or if you ever had a heart attack, jaundice, or pemphigoid gestationis (an itchy rash that develops into blisters). If you have asthma, migraine headaches, epilepsy (fits), kidney or heart problems, inform your doctor before taking Normonal CR Tablet .

Drug-Drug Interactions

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How does the drug interact with Normonal CR Tablet:
Coadministration of Phenytoin and Normonal CR Tablet may decrease the blood levels of Normonal CR Tablet, which may make Normonal CR Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Normonal CR Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Normonal CR Tablet:
Co-administration of Normonal CR Tablet with Bosentan can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
Taking Normonal CR Tablet with Bosentan together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to a doctor.
How does the drug interact with Normonal CR Tablet:
The combined use of Normonal CR Tablet and phenobarbital can reduce the blood levels and effects of Normonal CR Tablet.

How to manage the interaction:
Although taking phenobarbital and Normonal CR Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
NorethisteroneAmprenavir
Severe
How does the drug interact with Normonal CR Tablet:
Coadministration of Amprenavir and Normonal CR Tablet together may reduce amprenavir effects.

How to manage the interaction:
Combining Amprenavir with Normonal CR Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Normonal CR Tablet:
Coadministration of Normonal CR Tablet and Mycophenolic acid can decrease the levels and effects of Normonal CR Tablet.

How to manage the interaction:
There could be a possible interaction between Mycophenolic acid and Normonal CR Tablet, but they can be taken together if your doctor has prescribed them. However, if you experience hot flashes, vaginal dryness, or abnormal bleeding consult a doctor. Do not discontinue any medications without a doctor's advice.
NorethisteroneTelaprevir
Severe
How does the drug interact with Normonal CR Tablet:
Using Telaprevir and Normonal CR Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Normonal CR Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Normonal CR Tablet:
Taking carbamazepine and Normonal CR Tablet may possibly reduce the effects of Normonal CR Tablet which may result in higher risk of breakthrough bleeding and unexpected pregnancy.

How to manage the interaction:
Although taking carbamazepine and Normonal CR Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. Contact your doctor if you experience hot flashes, vaginal dryness, or uncontrolled bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Normonal CR Tablet:
Coadministration of Normonal CR Tablet and primidone can reduce the blood levels and effects of Normonal CR Tablet and increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Normonal CR Tablet and Primidone, they can be taken together if prescribed by a doctor. However, if you experience abnormal bleeding, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneFosphenytoin
Severe
How does the drug interact with Normonal CR Tablet:
Coadministration of Normonal CR Tablet with Fosphenytoin can reduces the blood levels and effects of Normonal CR Tablet .

How to manage the interaction:
Taking Normonal CR Tablet with Fosphenytoin together can result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms of abnormal bleeding while using birth control, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Normonal CR Tablet:
Coadministration of Normonal CR Tablet with Oxcarbazepine can reduce the blood levels and effects of norethindrone. This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Although taking oxcarbazepine and Normonal CR Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. If you experience any symptoms like abnormal bleeding, consult the doctor immediately Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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