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Pazotab 400 mg Tablet 30's
Pazotab 400 mg Tablet 30's
Pazotab 400 mg Tablet 30's
Pazotab 400 mg Tablet is an anti-cancer drug used in the treatment of kidney and soft tissue cancer. It contains Pazopanib, which works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. Thus, it stops the spread of cancerous cells. It may cause common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Pazotab 400 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Consult your doctor for dose adjustment or alternative medicine if you notice hair color changes.
  • To avoid further scalp irritation, use a mild shampoo and conditioner.
  • Avoid harsh styling techniques such as tight hairstyles and excessive heat styling.
  • Discuss your concerns with a professional hairstylist who can recommend color techniques to manage the look of hair color changes.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Drug-Drug Interactions

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PazopanibGrepafloxacin
Critical
PazopanibMesoridazine
Critical

Drug-Drug Interactions

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PazopanibGrepafloxacin
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pazotab 400 mg Tablet with Grepafloxacin can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Grepafloxacin is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PazopanibMesoridazine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Co-administration of Pazotab 400 mg Tablet with mesoridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Pazotab 400 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibThioridazine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pazotab 400 mg Tablet with Thioridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibPimozide
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pimozide with Pazotab 400 mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Pimozide is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibDronedarone
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking dronedarone together with Pazotab 400 mg Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Dronedarone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibHalofantrine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Using Pazotab 400 mg Tablet together with halofantrine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Halofantrine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibCisapride
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Using cisapride together with Pazotab 400 mg Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Cisapride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibSaquinavir
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Taking Pazotab 400 mg Tablet with Saquinavir can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibYellow fever vaccine
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Coadministration of Yellow fever vaccine with Pazotab 400 mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Yellow fever vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PazopanibSparfloxacin
Critical
How does the drug interact with Pazotab 400 mg Tablet:
Using Pazotab 400 mg Tablet together with sparfloxacin can increase the risk of abnormal heart rhythm

How to manage the interaction:
Taking Pazotab 400 mg Tablet with Sparfloxacin is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Coadministration of Pazotab 400 mg Tablet with grapefruit juice can increase the blood levels of Pazotab 400 mg Tablet, which may lead to an increased risk of serious side effects such as liver problems, irregular heart rhythm, bleeding, and high blood pressure. Avoid taking grapefruit juice along with Pazotab 400 mg Tablet, as it can lead to an interaction.

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