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compositionComposition:PAZOPANIB-400MG
prescription
Prescription Medicine
info
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Pazib 400 Tablet is an anti-cancer drug used in the treatment of kidney and soft tissue cancer. It contains Pazopanib, which works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. Thus, it stops the spread of cancerous cells. It may cause common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PAZOPANIB-400MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Pazib 400 Tablet

Pazib 400 Tablet is a prescription medicine used to treat advanced renal cell carcinoma, a type of kidney cancer, and certain advanced soft tissue sarcomas, which affect the body's supportive tissues. It belongs to a group of medicines called targeted therapies and works by interfering with signals involved in tumour growth and blood vessel formation.  This medicine helps manage these serious conditions by slowing down tumour growth.

For best results, you must take Pazib 400 Tablet consistently once daily. It is critical to take this medicine on an empty stomach; either at least 1 hour before a meal or 2 hours after a meal. Along with taking this medicine regularly, managing your blood pressure at home and eating a well-balanced diet can help support your overall health during treatment.

The duration of Pazib 400 Tablet treatment varies between individuals. Treatment is often continued for as long as the cancer remains controlled and side effects are manageable. Your oncology team will reassess your response regularly using clinical reviews, blood tests, and imaging when appropriate. Do not stop treatment on your own; if Pazib 400 Tablet needs to be discontinued, your doctor will guide the next steps in your cancer care. 

While taking Pazib 400 Tablet , you may experience some common side effects such as diarrhoea, changes in hair colour, nausea, and feeling tired. However, you must contact your healthcare provider immediately if you experience serious issues like severe bleeding, chest pain, or signs of liver damage.

Talk to your doctor before starting this medication if you have high blood pressure, heart problems, liver disease, bleeding problems, or a history of abnormal heart rhythms. Pazib 400 Tablet can cause serious harm to an unborn baby and should not be used during pregnancy unless your specialist determines that the potential benefit justifies the risk. If you could become pregnant, use effective contraception during treatment and for at least 2 weeks after the last dose. Men with partners who are pregnant or could become pregnant should use appropriate barrier contraception during treatment and for at least 2 weeks after the last dose.

This medicine can interact with several other drugs, including acid reducers and certain antifungal medicines, which can change how well it works. It is also important to avoid alcohol and smoking while taking Pazib 400 Tablet as they can strain your liver and cardiovascular system. If you are breastfeeding or are an older adult, consult your doctor to ensure this treatment is safe for you.
 

Uses of Pazib 400 Tablet

Pazib 400 Tablet is used to treat certain advanced cancers by blocking signals involved in tumour growth and the formation of new blood vessels. Its main uses include:

  • Advanced kidney cancer (renal cell carcinoma): Pazib 400 Tablet is used to treat adults with advanced kidney cancer by blocking the chemical signals that allow cancer cells to grow and divide.
  • Advanced soft tissue sarcoma: It helps treat patients who have received prior chemotherapy for advanced cancer that affects the body's supportive tissues, such as muscles, fat, and blood vessels.

Key Benefits

Pazib 400 Tablet is a targeted anticancer medicine used to treat certain advanced cancers. It works by blocking signals that cancer cells and tumours use to grow and develop new blood vessels.

  • Slows Cancer Progression: Helps limit the growth and multiplication of cancer cells, which may delay disease progression in certain cancers.
  • Restricts Tumour Blood Supply: Blocks signals involved in the formation of new blood vessels that tumours need for oxygen and nutrients, helping restrict further tumour growth.
  • Helps Control Tumour Growth: May shrink tumours or keep them stable for a period of time, depending on the type of cancer and individual response to treatment.
  • Supports Long-Term Disease Management: In responsive patients, Pazib 400 Tablet may help maintain disease control and delay worsening of advanced cancer.
  • Offers Oral Treatment: As a tablet taken by mouth, Pazib 400 Tablet can often be taken at home according to the prescribed schedule, reducing the need for administration by intravenous infusion.
Side effects of Pazib 400 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Consult your doctor for dose adjustment or alternative medicine if you notice hair color changes.
  • To avoid further scalp irritation, use a mild shampoo and conditioner.
  • Avoid harsh styling techniques such as tight hairstyles and excessive heat styling.
  • Discuss your concerns with a professional hairstylist who can recommend color techniques to manage the look of hair color changes.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

Directions for Use

  • Pazib 400 Tablet should be taken without food, preferably on an empty stomach, at least 1-2 hours before a meal.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Pazib 400 Tablet Works

Pazib 400 Tablet contains pazopanib, which works as a targeted cancer therapy known as a kinase inhibitor. It functions by blocking specific proteins called tyrosine kinases on the surface of cancer cells and blood vessels. These proteins act as signals that tell the cancer cells to grow and multiply. Additionally, these signals help tumours create their own network of new blood vessels, a process that feeds the tumour with oxygen and nutrients. By blocking these proteins, Pazib 400 Tablet cuts off the blood supply to the tumour and stops growth signals, effectively starving the cancer cells and slowing down their spread.
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption with Pazib 400 Tablet as it may increase the risk of side effects such as dizziness, drowsiness or difficulty in concentrating.

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Pregnancy

Unsafe

Pazib 400 Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Pazib 400 Tablet .

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Breast Feeding

Unsafe

Pazib 400 Tablet should not be taken by breastfeeding mothers as it passes into breast milk and may cause possible risk to the infant.

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Driving

Caution

It is not known if Pazib 400 Tablet may affect your driving ability or not.

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Liver

Safe if prescribed

Pazib 400 Tablet should be taken with caution in patients dealing with the liver disease. The dose may be adjusted by the doctor according to the medical condition of the patient.

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Kidney

Safe if prescribed

Pazib 400 Tablet is safe to take by patients dealing with kidney cancer as prescribed by their doctor. The dose may be adjusted by the doctor according to the medical condition of the patient.

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Children

Unsafe

Pazib 400 Tablet is not recommended for children below 18 years as the safety and effectiveness were not established.

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Heart

Unsafe

This medicine is not recommended for cardiac patients due to its adverse effects.

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Geriatrics

Safe if prescribed

Pazib 400 Tablet is safe for use in elderly patients if prescribed by the physician.

What if I have taken an overdose of Pazib 400 Tablet

In case of an accidental overdose, seek immediate emergency medical attention or contact a poison control centre right away, even if you do not feel any symptoms.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as it can dangerously increase the levels of Pazib 400 Tablet in your body.
  • Monitor your blood pressure: Check your blood pressure daily at home and keep a log for your healthcare team, as this medication can cause sudden rises in blood pressure.
  • Stay hydrated: Drink plenty of clear fluids throughout the day to prevent dehydration, especially if you experience diarrhoea or vomiting.
  • Plan around surgeries: Because this medicine can slow down wound healing, tell your doctor or dentist you are taking Pazib 400 Tablet before scheduling any surgical or dental procedures.
  • Use effective birth control: Both men and women should use reliable birth control during treatment and for several weeks after stopping, as this medication can harm a developing baby.
health query

Have a query?

How Soon It Starts Working

The time required for Pazib 400 Tablet to start to work: The time required for Pazib 400 Tablet to show its action is unknown. The time for which the effects of Pazib 400 Tablet last: The duration of action for Pazib 400 Tablet is unknown.

What if you forget to take Pazib 400 Tablet

If you miss a dose of Pazib 400 Tablet , take it as soon as you remember. However, if your next scheduled dose is less than 12 hours away, skip the missed dose and take your next dose at your regular time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Pazib 400 Tablet tablets at room temperature, between 20°C and 25°C (68°F to 77°F). •Keep the bottle tightly closed when not in use to protect the tablets from moisture and light.

Drug Warnings

  • Monitor Your Blood Pressure: Check your blood pressure as advised and keep a record for your healthcare team, as Pazib 400 Tablet can cause significant increases in blood pressure.
  • Keep Up With Thyroid Tests: Attend scheduled blood tests to check thyroid function. Tell your doctor if you develop persistent fatigue, unexplained weight gain, constipation, dry skin, or increased sensitivity to cold.
  • Attend Urine Protein Checks: Keep scheduled urine tests, as Pazib 400 Tablet can cause protein to leak into the urine. Tell your doctor if you notice unusually foamy urine or new swelling around the eyes, feet, or legs.
  • Attend Heart Monitoring When Advised: Keep appointments for ECGs or other heart checks recommended by your doctor, particularly if you have existing heart problems or other risk factors for abnormal heart rhythms.
  • Plan Ahead for Surgery: Tell your oncology team before any planned surgery or dental procedure, as Pazib 400 Tablet can interfere with wound healing and may require temporary treatment adjustments.
  • Check Before Starting New Products: Ask your doctor or pharmacist before taking any new prescription medicine, over-the-counter product, vitamin, or herbal supplement, as some products can alter Pazib 400 Tablet levels or increase side effects.
  • Do Not Stop Treatment on Your Own: Continue Pazib 400 Tablet for as long as prescribed. Your oncology team will regularly assess whether treatment should continue, be paused, adjusted, or stopped based on cancer control and side effects.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Pazib 400 Tablet :

  • Acid reducers (such as proton pump inhibitors, H2 blockers, and antacids): May decrease the absorption of Pazib 400 Tablet , making it less effective.
  • Strong CYP3A4 inhibitors (like ketoconazole or clarithromycin): May increase the amount of Pazib 400 Tablet in your body, raising the risk of severe side effects.
  • Strong CYP3A4 inducers (like rifampin or phenytoin): May decrease the levels of Pazib 400 Tablet in your blood, reducing its ability to fight cancer cells.
  • Medicines that affect heart rhythm: May increase the risk of serious irregular heartbeats when combined with this medication.
PazopanibThioridazine
Critical
PazopanibZiprasidone
Critical

Drug-Drug Interactions

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PazopanibThioridazine
Critical
How does the drug interact with Pazib 400 Tablet:
Taking Pazib 400 Tablet with Thioridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazib 400 Tablet with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibZiprasidone
Critical
How does the drug interact with Pazib 400 Tablet:
Taking Pazib 400 Tablet with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Pazib 400 Tablet and Ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibAluminium hydroxide
Critical
How does the drug interact with Pazib 400 Tablet:
Co-administration of Pazib 400 Tablet with aluminium hydroxide can reduce the blood levels and effects of Pazib 400 Tablet.

How to manage the interaction:
Although there is an interaction between Pazib 400 Tablet and Aluminium hydroxide, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PazopanibSaquinavir
Critical
How does the drug interact with Pazib 400 Tablet:
Taking Pazib 400 Tablet with Saquinavir can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Pazib 400 Tablet with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibBCG vaccine
Critical
How does the drug interact with Pazib 400 Tablet:
Taking BCG vaccine with Pazib 400 Tablet can increase the risk of infection.

How to manage the interaction:
Taking Pazib 400 Tablet with BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
PazopanibCisapride
Critical
How does the drug interact with Pazib 400 Tablet:
Using cisapride together with Pazib 400 Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Pazib 400 Tablet with Cisapride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibDronedarone
Critical
How does the drug interact with Pazib 400 Tablet:
Taking dronedarone together with Pazib 400 Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Pazib 400 Tablet with Dronedarone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibSparfloxacin
Critical
How does the drug interact with Pazib 400 Tablet:
Using Pazib 400 Tablet together with sparfloxacin can increase the risk of abnormal heart rhythm

How to manage the interaction:
Taking Pazib 400 Tablet with Sparfloxacin is not recommended, but can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
PazopanibMesoridazine
Critical
How does the drug interact with Pazib 400 Tablet:
Co-administration of Pazib 400 Tablet with mesoridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Pazib 400 Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
PazopanibPimozide
Critical
How does the drug interact with Pazib 400 Tablet:
Taking Pimozide with Pazib 400 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Pazib 400 Tablet with Pimozide is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and dietary factors can significantly affect how Pazib 400 Tablet is absorbed or processed by the body. Important interactions include:

  • Grapefruit and grapefruit juice: Can significantly raise the levels of Pazib 400 Tablet in your blood, increasing the risk of serious side effects.
  • Food: Taking this medicine with a meal dramatically increases how much medicine your body absorbs, which can lead to dangerous side effects. Always take it on an empty stomach.
PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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PAZOPANIB-400MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Coadministration of Pazib 400 Tablet with grapefruit juice can increase the blood levels of Pazib 400 Tablet, which may lead to an increased risk of serious side effects such as liver problems, irregular heart rhythm, bleeding, and high blood pressure. Avoid taking grapefruit juice along with Pazib 400 Tablet, as it can lead to an interaction.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Pazib 400 Tablet is used in the treatment of kidney and soft tissue cancer.
Pazib 400 Tablet is safe to be taken by a diabetic person. However, take Pazib 400 Tablet only after asking with a doctor as they may adjust the dosing according to the condition of the patient.
Pazib 400 Tablet is restricted to use in pregnancy. A woman needs to have a negative pregnancy test before starting treatment with this medicine. It is better to use effective birth control methods to prevent pregnancy while taking this medicine or for at least 6 months after taking the last dose of Pazib 400 Tablet .
Before your doctor prescribes you Pazib 400 Tablet , tell them if you have heart problems, high blood pressure, bleeding issues, surgery or an electrolyte imbalance (like abnormal levels of magnesium, calcium, or potassium in the blood).
Pazib 400 Tablet is restricted to use in persons who are sensitive to any of its constituents or have squamous cell lung cancer or already taking carboplatin and paclitaxel.
Pazib 400 Tablet is not a chemotherapy medicine. It belongs to an anti-cancer group of medicines called protein kinase inhibitors. Pazib 400 Tablet works by preventing the activity of proteins that are involved in the growth and spread of cancer cells.
Take Pazib 400 Tablet by orally as prescribed by your physician. Consume it whole with water. Breaking or crushing it will interfere with Pazib 400 Tablet 's absorption and raise the chance of adverse effects.
No, Pazib 400 Tablet should not be taken with food as it increases the amount of Pazib 400 Tablet absorbed into the body and may increase the risk of side effects. It is best to take it on an empty stomach, either 1 hour before or 2 hours after a meal. However, always take Pazib 400 Tablet as advised by your doctor.
It may take several weeks or months for you to see or feel the benefits but do not stop taking it unless your doctor tells you to. Regular check-ups and imaging tests will help your doctor assess the effectiveness of the treatment. However, it is important to monitor for side effects like diarrhoea, high blood pressure, and fatigue, and consult your doctor if you have any concerns.
Yes, there are some food restrictions while taking Pazib 400 Tablet . You are recommended to avoid grapefruit and grapefruit juice, as it may increase the risk of side effects. If you have any concerns about foods to avoid while taking Pazib 400 Tablet , please discuss with your doctor.
Some important things you should know about Pazib 400 Tablet are side effects it may cause such as serious or life-threatening liver damage. If you experience any of the following symptoms like yellowing of the skin or eyes, dark urine , extreme tiredness , nausea, vomiting , loss of appetite, pain in the upper right part of the stomach, unusual bleeding or bruising, inform your doctor. Pazib 400 Tablet should be used with caution in patients with liver disease.
You must swallow Pazib 400 Tablet tablets whole. Crushing, chewing, or splitting the tablets increases the speed at which the medicine is absorbed into your body, which can dangerously increase the risk of severe side effects. If you have trouble swallowing tablets, talk to your doctor or pharmacist.
Yes, a common side effect of Pazib 400 Tablet is a loss of hair colour or hair lightening during treatment. This is a temporary effect and your hair colour typically returns to normal after you stop taking the medication. Talk to your doctor if you have concerns about hair or skin changes.
Pazib 400 Tablet can cause severe liver damage. Your doctor will perform regular blood tests to check your liver function before and during your treatment, especially in the first few months. If you notice yellowing of your skin or eyes, dark urine, or severe stomach pain, contact your doctor immediately.
Pazib 400 Tablet can cause high blood pressure, often within the first few weeks of starting treatment. You should monitor your blood pressure daily at home. If your blood pressure rises, your doctor may prescribe blood pressure medication or adjust your dose. Talk to your doctor if you notice high readings.
This medicine can impair your body's ability to heal wounds. If you have an upcoming surgery or dental procedure, your doctor will likely recommend stopping Pazib 400 Tablet temporarily before and after the procedure to allow proper healing. Talk to your doctor before scheduling any procedures.
Acid-reducing medicines, like proton pump inhibitors and H2 blockers, can lower the absorption of Pazib 400 Tablet , making it less effective. If you need to manage acid reflux or heartburn, talk to your doctor or pharmacist to find a safe alternative or a specific dosing schedule.
Pazib 400 Tablet can sometimes cause protein to leak from the kidneys into the urine. Regular urine tests help detect this problem early. Tell your doctor if you notice unusually foamy urine, swelling around the eyes or legs, or changes in how often you urinate.

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Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - PAZ0067
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