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Purinol 300mg Tablet

Purinol 300mg Tablet is used to reduce blood uric acid levels. It is used to treat Gout (increased uric acid leading to inflammation), kidney stones, and bladder stones. It contains Allopurinol, which stops uric acid production in the body and prevents crystal buildup. Common side effects include stomach upset, diarrhoea, skin rash, and drowsiness.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Purinol 300mg Tablet
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Limit processed foods and eat more vegetables and fruits.
  • Exercise at least 30 minutes every day.
  • Maintain a healthy weight.
  • Quit smoking as it can worsen kidney damage.
  • Control your blood pressure and blood glucose.
  • Limit salt intake and alcohol consumption.
  • Take cold water baths avoiding soap.
  • Avoid scratching and scrubbing to prevent infections while itching.
  • Use nets to prevent insects and mosquitoes.
  • Stop using lotions and creams that cause irritation.
  • Avoid alcohol and caffeine intake.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

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Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Purinol 300mg Tablet may interact with certain medicines, potentially increasing side effects or altering their effectiveness. Inform your doctor if you are taking any of the following:

  • Anti-HIV drugs (Didanosine)
    • Potential effect: May increase the blood levels of Didanosine.
  • Drugs used for high blood pressure (Lisinopril, Ramipril, Captopril)
    • Potential effect: May increase the risk of severe allergic reactions and infections.
  • Uric acid-lowering drugs (Pegloticase)
    • Potential effect: May increase the risk of side effects.
  • Anticancer drugs (Mercaptopurine)
    • Potential effect: May increase the effectiveness of Mercaptopurine.
  • Antiviral drugs (Entecavir)
    • Potential effect: May increase the blood levels of both medications and the risk of side effects.

Drug-Food Interactions: Purinol 300mg Tablet should not be taken along with alcohol, as it can increase uric acid levels.

Drug-Disease Interactions: Purinol 300mg Tablet should be used with caution in individuals with thyroid disease, hypertension, or heart, liver, or kidney disease.

AllopurinolDidanosine
Critical
AllopurinolMoexipril
Severe

Drug-Drug Interactions

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AllopurinolDidanosine
Critical
How does the drug interact with Purinol 300mg Tablet:
When Didanosine is taken with Purinol 300mg Tablet, can increase the blood levels of didanosine.

How to manage the interaction:
Taking Purinol 300mg Tablet with Didanosine lead to an interaction, please consult a doctor before taking it. Do not discontinue the medication without consulting a doctor.
AllopurinolMoexipril
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Moexipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Purinol 300mg Tablet and Moexipril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also, let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue any medications without consulting a doctor.
AllopurinolTrandolapril
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Trandolapril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Purinol 300mg Tablet and Trandolapril you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolPegloticase
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Pegloticase can increase the chances of side effects.

How to manage the interaction:
Co-administration of Purinol 300mg Tablet with Pegloticase can possibly result in an interaction, but it can be taken if your doctor has advised it. This is more common in people who already have high uric acid levels, which may not be obvious if they are taking other uric acid-lowering medications. Do not stop using any medications without first talking to your doctor.
AllopurinolLisinopril
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Lisinopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Purinol 300mg Tablet and Lisinopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness chills, sore throat, extreme tiredness, body pains, consult a doctor. Do not discontinue any medications without consulting a doctor.
AllopurinolAzathioprine
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Azathioprine may increase the effects of azathioprine.

How to manage the interaction:
There may be a possibility of interaction between Azathioprine and Purinol 300mg Tablet, but it can be taken if prescribed by a doctor. However, if you experience chills, fever, body pains, sore throat, weakness, muscle pain, mouth sores, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhoea, consult a doctor. Do not stop using any medications without a doctor's advice.
AllopurinolMercaptopurine
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Mercaptopurine together may increase the effects of mercaptopurine.

How to manage the interaction:
If you take Purinol 300mg Tablet and Mercaptopurine together, a doctor may adjust the dose or recommend special tests to use both medications safely. However, contact a doctor immediately if you develop any symptoms such as chills, fever, sore throat, mouth sores, body pains, weakness, muscle pain, easy bruising or bleeding, pale stools, darkened urine, or severe nausea, vomiting, and diarrhea. Do not discontinue any medications without a doctor's advice.
AllopurinolCaptopril
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Captopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Purinol 300mg Tablet and Captopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact your doctor immediately. Also let your doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
AllopurinolDeferiprone
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Deferiprone may increase the risk of dangerous blood clots.

How to manage the interaction:
If you are supposed to take Purinol 300mg Tablet and Deferiprone together, your doctor may advise you to take blood thinner or monitor you more frequently to safely use both medications. However, if you experience shortness of breath, chest pain, coughing up blood, difficulty breathing, sudden loss of vision, and/or pain, redness or swelling in an arm or leg, contact your doctor immediately as these may be signs and symptoms of blood clots. Do not discontinue any medications without consulting a doctor.
AllopurinolPerindopril
Severe
How does the drug interact with Purinol 300mg Tablet:
Co-administration of Purinol 300mg Tablet with Perindopril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Purinol 300mg Tablet and Perindopril, you can take these medicines together if prescribed by your doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms, contact your doctor immediately . Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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