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Drug-Drug Interactions
Critical
KetoconazoleMethadone
Critical
Drug-Drug Interactions
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Critical
How does the drug interact with Symketo 200mg Tablet:
Coadministration of Lovastatin with Symketo 200mg Tablet can increase the risk of liver damage, rhabdomyolysis (the breakdown of skeletal muscle tissue) which may lead to kidney damage.
How to manage the interaction:
Taking Symketo 200mg Tablet with Lovastatin is not recommended as it can cause an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms like unexplained muscular pain, tenderness, weakness, accompanied by fever, dark urine or unexpected bruising or bleeding, skin rash, itching, vomiting, yellowing of the skin or eyes, chills, joint pain, swelling, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
Coadministration of Lovastatin with Symketo 200mg Tablet can increase the risk of liver damage, rhabdomyolysis (the breakdown of skeletal muscle tissue) which may lead to kidney damage.
How to manage the interaction:
Taking Symketo 200mg Tablet with Lovastatin is not recommended as it can cause an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms like unexplained muscular pain, tenderness, weakness, accompanied by fever, dark urine or unexpected bruising or bleeding, skin rash, itching, vomiting, yellowing of the skin or eyes, chills, joint pain, swelling, consult a doctor immediately. Do not discontinue any medication without consulting a doctor.
KetoconazoleMethadone
Critical
How does the drug interact with Symketo 200mg Tablet:
When Methadone is taken with Symketo 200mg Tablet, it can increase the risk of serious side effects such as respiratory problems, low blood pressure, irregular heart rhythm.
How to manage the interaction:
Taking Symketo 200mg Tablet with Methadone is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience breathing difficulty, fainting, heart palpitations, consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
When Methadone is taken with Symketo 200mg Tablet, it can increase the risk of serious side effects such as respiratory problems, low blood pressure, irregular heart rhythm.
How to manage the interaction:
Taking Symketo 200mg Tablet with Methadone is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience breathing difficulty, fainting, heart palpitations, consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
Critical
How does the drug interact with Symketo 200mg Tablet:
When Tolvaptan is taken with Symketo 200mg Tablet, may increase the risk of side effects.
How to manage the interaction:
Taking Tolvaptan with Symketo 200mg Tablet is not recommended as it can lead to an interaction, it can be taken if prescribed by a doctor. However, if you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
When Tolvaptan is taken with Symketo 200mg Tablet, may increase the risk of side effects.
How to manage the interaction:
Taking Tolvaptan with Symketo 200mg Tablet is not recommended as it can lead to an interaction, it can be taken if prescribed by a doctor. However, if you notice any of these signs -difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures, call a doctor right away. Do not stop using any medications without a doctor's advice.
Critical
How does the drug interact with Symketo 200mg Tablet:
Coadministration of Ivabradine with Symketo 200mg Tablet can increase the risk or severity of side effects.
How to manage the interaction:
Taking Ivabradine with Symketo 200mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Coadministration of Ivabradine with Symketo 200mg Tablet can increase the risk or severity of side effects.
How to manage the interaction:
Taking Ivabradine with Symketo 200mg Tablet is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
KetoconazoleDofetilide
Critical
How does the drug interact with Symketo 200mg Tablet:
When Dofetilide is taken with Symketo 200mg Tablet, it can increase the chance of a serious abnormal heart rhythm.
How to manage the interaction:
Taking Symketo 200mg Tablet with Dofetilide is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
When Dofetilide is taken with Symketo 200mg Tablet, it can increase the chance of a serious abnormal heart rhythm.
How to manage the interaction:
Taking Symketo 200mg Tablet with Dofetilide is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
KetoconazoleConivaptan
Critical
How does the drug interact with Symketo 200mg Tablet:
Using conivaptan together with Symketo 200mg Tablet may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.
How to manage the interaction:
Taking Symketo 200mg Tablet with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
Using conivaptan together with Symketo 200mg Tablet may significantly increase the blood levels of conivaptan, which may increase the risk of side effects.
How to manage the interaction:
Taking Symketo 200mg Tablet with Conivaptan is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, seizures(fits), consult the doctor immediately. Do not discontinue any medication without consulting a doctor.
Critical
How does the drug interact with Symketo 200mg Tablet:
When Cisapride is taken with Symketo 200mg Tablet, it can increase the chance of a serious abnormal heart rhythm.
How to manage the interaction:
Taking Cisapride with Symketo 200mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
When Cisapride is taken with Symketo 200mg Tablet, it can increase the chance of a serious abnormal heart rhythm.
How to manage the interaction:
Taking Cisapride with Symketo 200mg Tablet is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
Critical
How does the drug interact with Symketo 200mg Tablet:
Co-administration of Alprazolam with Symketo 200mg Tablet may considerably increase the blood levels of Alprazolam, which may result in side effects.
How to manage the interaction:
Although there is an interaction between Alprazolam and Symketo 200mg Tablet, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
Co-administration of Alprazolam with Symketo 200mg Tablet may considerably increase the blood levels of Alprazolam, which may result in side effects.
How to manage the interaction:
Although there is an interaction between Alprazolam and Symketo 200mg Tablet, it can be taken if prescribed by a doctor. Consult a doctor if you experience excessive or prolonged drowsiness or difficulty in breathing. Do not discontinue any medications without consulting a doctor.
KetoconazoleNisoldipine
Critical
How does the drug interact with Symketo 200mg Tablet:
When Nisoldipine is taken with Symketo 200mg Tablet, it can increase the blood levels of Nimodipine which may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, and extremely low blood pressure).
How to manage the interaction:
Taking Symketo 200mg Tablet with Nisoldipine can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience irregular heart rhythm, fluid retention, swelling, and extremely low blood pressure while using these medications, consult the doctor. Do not stop using any medications without talking to a doctor.
When Nisoldipine is taken with Symketo 200mg Tablet, it can increase the blood levels of Nimodipine which may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, and extremely low blood pressure).
How to manage the interaction:
Taking Symketo 200mg Tablet with Nisoldipine can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience irregular heart rhythm, fluid retention, swelling, and extremely low blood pressure while using these medications, consult the doctor. Do not stop using any medications without talking to a doctor.
KetoconazoleVenetoclax
Critical
How does the drug interact with Symketo 200mg Tablet:
When Venetoclax is taken with Symketo 200mg Tablet, it can increase the risk of side effects.
How to manage the interaction:
Taking Symketo 200mg Tablet with Venetoclax is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. if you experience nausea, vomiting, diarrhea, fatigue, bleeding problems, and infections, consult a doctor. Do not stop using any medications without talking to a doctor.
When Venetoclax is taken with Symketo 200mg Tablet, it can increase the risk of side effects.
How to manage the interaction:
Taking Symketo 200mg Tablet with Venetoclax is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. if you experience nausea, vomiting, diarrhea, fatigue, bleeding problems, and infections, consult a doctor. Do not stop using any medications without talking to a doctor.
Drug-Food Interactions
KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Drug-Food Interactions
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KETOCONAZOLE-200MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit
How to manage the interaction:
Consumption of grapefruit or its juice with Symketo 200mg Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Symketo 200mg Tablet.
Grapefruit Juice, Grapefruit
How to manage the interaction:
Consumption of grapefruit or its juice with Symketo 200mg Tablet may result in side effects such as joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, dark urine, light colored stools, and yellowing of the skin or eyes. Avoid consuming grapefruit, grapefruit juice, or any supplements that include grapefruit extract while taking Symketo 200mg Tablet.
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