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Reviewed By Santoshini Reddy G , M Pharmacy

Valkem 500 Oral Solution is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Side effects of Valkem 500 Oral Solution 100 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexSodium oxybate
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Glycerol phenylbutyrate and Valkem 500 Oral Solution 100 ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Valkem 500 Oral Solution 100 ml together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium oxybate
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Sodium oxybate and Valkem 500 Oral Solution 100 ml can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Sodium oxybate and Valkem 500 Oral Solution 100 ml can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like dizziness, sweating, palpitations, and shortness of breath, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexBexarotene
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Meropenem can reduce the blood levels of Valkem 500 Oral Solution 100 ml sodium.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexEsketamine
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Esketamine and Valkem 500 Oral Solution 100 ml can increase the side effects of esketamine.

How to manage the interaction:
Although taking Valkem 500 Oral Solution 100 ml and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
DivalproexMipomersen
Severe
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Ketoconazole and Valkem 500 Oral Solution 100 ml may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Valkem 500 Oral Solution 100 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Co-administration of Valkem 500 Oral Solution 100 ml and Doripenem can reduce the blood levels of Valkem 500 Oral Solution 100 ml sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Valkem 500 Oral Solution 100 ml with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Valkem 500 Oral Solution 100 ml and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Valkem 500 Oral Solution 100 ml and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
How does the drug interact with Valkem 500 Oral Solution 100 ml:
Coadministration of Ertapenem with Valkem 500 Oral Solution 100 ml may reduce the blood levels of Valkem 500 Oral Solution 100 ml and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Valkem 500 Oral Solution 100 ml if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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