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  3. ABCIXIREL 10MG INJECTION 5ML

ABCIXIREL 10MG INJECTION 5ML, Pack of 1 Injection
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

ABCIXIREL 10MG INJECTION is used to prevent the formation of blood clots, thereby reducing the chance of Myocardial infarction. ABCIXIREL 10MG INJECTION contains Abciximab, which works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST). This medicine is always administered along with aspirin and heparin.

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Composition :

ABCIXIMAB-2MG

Manufacturer/Marketer :

Reliance Life Sciences

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ABCIXIREL 10MG INJECTION

ABCIXIREL 10MG INJECTION belongs to the group of medicines called 'antiplatelet agents' used to prevent the formation of blood clots, thereby reducing the chance of Myocardial infarction. ABCIXIREL 10MG INJECTION is used as an adjunct during percutaneous coronary intervention (PCI) procedure in patients with unstable angina not responding to conventional medical therapy when PCI procedure is planned within 24 hours.

ABCIXIREL 10MG INJECTION contains Abciximab, which belongs to the monoclonal anti-glycoprotein IIb/IIIa receptor antibodies class. It works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST).

ABCIXIREL 10MG INJECTION may cause certain side effects such as bleeding, nausea, headache, abdominal pain, hypotension, vomiting, dizziness, back pain, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare professional will administer ABCIXIREL 10MG INJECTION. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

ABCIXIREL 10MG INJECTION should be avoided if you are allergic to it. It is contraindicated in patients who have active internal bleeding, thrombocytopenia, severe uncontrolled hypertension, had recent major surgery or trauma, a history of cerebrovascular accident within the last two years, or recent gastrointestinal or genitourinary bleeding, intracranial neoplasm, aneurysm, used dextran before PCI procedure, and history of vasculitis as it can cause serious adverse effects. ABCIXIREL 10MG INJECTION is administered along with aspirin and heparin. Hence, close monitoring of patients is needed for any bleeding conditions. Talk to your doctor before receiving ABCIXIREL 10MG INJECTION, have/had a recent severe injury or surgery due to risk of severe bleeding problems. If you are pregnant or breastfeeding, inform your doctor before receiving this medicine. ABCIXIREL 10MG INJECTION is not recommended for children below 12 years of age as efficacy and safety have not been established.

Uses of ABCIXIREL 10MG INJECTION

Treatment of Myocardial infarction (heart attack)

Directions for Use

A trained healthcare professional will administer ABCIXIREL 10MG INJECTION. Hence, do not self-administer.

Medicinal Benefits

ABCIXIREL 10MG INJECTION contains Abciximab, which belongs to the monoclonal anti-glycoprotein IIb/IIIa receptor antibodies class. It works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST). This medicine is always administered along with aspirin and heparin.

How ABCIXIREL 10MG INJECTION Works

ABCIXIREL 10MG INJECTION contains Abciximab, which belongs to the monoclonal anti-glycoprotein IIb/IIIa receptor antibodies class. It works by blocking the glycoprotein IIb/IIIa receptor's activity, thereby preventing platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation. ABCIXIREL 10MG INJECTION results in reducing the risk of cardiovascular events like myocardial infarction (heart attack), repeat coronary revascularization, and stent thrombosis (ST).

Storage

Store in a cool and dry place away from sunlight
Side effects of Abcixirel 10mg Injection 5ml
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Managing back pain as a side effect of medication requires a combination of self-care techniques, lifestyle modifications, and medical interventions. Here are the steps:
  • Talk to your doctor about your back pain and potential medication substitutes or dose changes.
  • Try yoga or Pilates and other mild stretching exercises to increase flexibility and strengthen your back muscles.
  • To lessen the tension on your back, sit and stand upright and maintain proper posture.
  • To alleviate discomfort and minimize inflammation, apply heat or cold packs to the afflicted area.
  • Under your doctor's supervision, think about taking over-the-counter painkillers like acetaminophen or ibuprofen.
  • Make ergonomic adjustments to your workspace and daily activities to reduce strain on your back.
  • To handle tension that could make back pain worse, try stress-reduction methods like deep breathing or meditation.
  • Use pillows and a supportive mattress to keep your spine in the right posture as you sleep.
  • Back discomfort can worsen by bending, twisting, and heavy lifting.
  • Speak with a physical therapist to create a customized training regimen to increase back strength and flexibility.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

What if I have taken an overdose of ABCIXIREL 10MG INJECTION

As ABCIXIREL 10MG INJECTION is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Do not receive ABCIXIREL 10MG INJECTION if you are allergic to it. This medicine is contraindicated in patients having active internal bleeding, thrombocytopenia, recent major surgery or trauma, severe uncontrolled hypertension, history of cerebrovascular accident within two years, or recent gastrointestinal or genitourinary bleeding, intracranial neoplasm, aneurysm, use of dextran before PCI procedure, and history of vasculitis as it can cause serious adverse effects. ABCIXIREL 10MG INJECTION is administered along with aspirin and heparin. Hence, close monitoring of patients is needed for any bleeding conditions. Talk to your doctor before receiving ABCIXIREL 10MG INJECTION if you have/had a recent severe injury or surgery due to the risk of severe bleeding problems. If you are pregnant or breastfeeding, inform your doctor before receiving this medicine. ABCIXIREL 10MG INJECTION is not recommended for children below 12 years of age as efficacy and safety have not been established.

Drug-Drug Interactions

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AbciximabRivaroxaban
Severe
AbciximabProtamine
Severe

Drug-Drug Interactions

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AbciximabRivaroxaban
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Co-administration of Abcixirel 10mg Injection 5ml and Rivaroxaban can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Abcixirel 10mg Injection 5ml and Rivaroxaban can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
AbciximabProtamine
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Coadministration of protamine and Abcixirel 10mg Injection 5ml can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Protamine with Abcixirel 10mg Injection 5ml can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without first talking to your doctor.
AbciximabEnoxaparin
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Combining Abcixirel 10mg Injection 5ml with Enoxaparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Abcixirel 10mg Injection 5ml and Enoxaparin together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms like feeling dizzy or lightheaded, dark or tar-like stools, a severe headache, feeling weak, bruising, bleeding, or vomiting, it's important to contact your doctor right away. Do not stop using any medications without first talking to a doctor.
AbciximabPrasugrel
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Co-administration of Abcixirel 10mg Injection 5ml with Prasugrel can increase the risk of bleeding.

How to manage the interaction:
Taking Prasugrel with Abcixirel 10mg Injection 5ml together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you have any of the following symptoms: unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor. Do not stop using any medications without talking to a doctor.
AbciximabCangrelor
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Co-administration of Abcixirel 10mg Injection 5ml with Cangrelor can increase the risk of bleeding.

How to manage the interaction:
Co-administration of Cangrelor with Abcixirel 10mg Injection 5ml can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs, it's important to contact a doctor right away: difficulty with bleeding, complications, bruising, feeling dizzy or lightheaded, dark or sticky stools, intense headache, weakness, or bleeding or vomiting. Do not stop using any medications without talking to a doctor.
AbciximabDeferasirox
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Using deferasirox together with Abcixirel 10mg Injection 5ml may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Abcixirel 10mg Injection 5ml with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts.If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
AbciximabDalteparin
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
The combined use of Abcixirel 10mg Injection 5ml with Dalteparin can increase the risk of bleeding.

How to manage the interaction:
Taking Abcixirel 10mg Injection 5ml with Dalteparin together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as bleeding, severe bleeding, bruising, dark or black stools, severe headache, weakness, bleeding, or vomiting. Do not discontinue any medications without consulting a doctor.
AbciximabDabigatran etexilate
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Taking Dabigatran etexilate with Abcixirel 10mg Injection 5ml can increase the risk of bleeding leading to serious blood loss.

How to manage the interaction:
Taking Dabigatran etexilate with Abcixirel 10mg Injection 5ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without a doctor's advice.
AbciximabFondaparinux
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Taking Abcixirel 10mg Injection 5ml with fondaparinux can increase the risk of bleeding.

How to manage the interaction:
Although there is an interaction between Abcixirel 10mg Injection 5ml and Fondaparinux, it can be taken if prescribed by a doctor. However, if you experience bleeding, bruising, feeling dizzy or lightheaded, dark or black stools, severe headache, weakness, bleeding, or vomiting contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AbciximabWarfarin
Severe
How does the drug interact with Abcixirel 10mg Injection 5ml:
Coadministration of Warfarin with Abcixirel 10mg Injection 5ml can increase the effect of Warfarin.

How to manage the interaction:
Although there is a possible interaction between Warfarin and Abcixirel 10mg Injection 5ml, you can take these medicines together if prescribed by a doctor. However, if you experience unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, contact a doctor. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a diet rich in whole grains, vegetables, fruits, skinless poultry, fish, eggs, and low-fat dairy products.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight with proper diet and exercise.
  • Managing stress with meditation, yoga, and massage.
  • Avoid eating fried food, fast food, boxed food, canned food, and processed frozen meals.

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Hence, avoid alcohol consumption. Consult your doctor for more information.

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Pregnancy

Caution

It is also unknown whether ABCIXIREL 10MG INJECTION can cause fetal damage or alter reproductive capacity when given to a pregnant woman. Your doctor may prescribe this medicine only if clearly needed.

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Breast Feeding

Caution

Limited data are available on the effect of ABCIXIREL 10MG INJECTION on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving ABCIXIREL 10MG INJECTION. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

ABCIXIREL 10MG INJECTION is used in PCI procedures in a hospital setting. Driving is not recommended.

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Liver

Caution

If you have liver problems, inform your doctor beforehand.

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Kidney

Unsafe

If you have kidney impairment, inform your doctor beforehand.

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Children

Unsafe

ABCIXIREL 10MG INJECTION is not recommended for use in children below 12 years of age, as efficacy and safety have not been established.

Have a query?

FAQs

ABCIXIREL 10MG INJECTION is used to treat Myocardial infarction (heart attack).

ABCIXIREL 10MG INJECTION contains Abciximab, which works by blocking the activity of glycoprotein IIb/IIIa receptor and thereby prevents platelet aggregation. This causes inhibition of fibrinogen binding, reducing the chance of blood clot formation.

ABCIXIREL 10MG INJECTION is usually administered along with heparin and aspirin, so it might increase the risk of bleeding. Inform the doctor immediately if you notice excess bleeding.

ABCIXIREL 10MG INJECTION may cause anaemia (low haemoglobin and low red blood cell count). So, it would be best to include iron-rich food in your diet to prevent anaemia.

While taking ABCIXIREL 10MG INJECTION, avoid medicines like painkillers (aspirin, ibuprofen, celecoxib, hydrocodone, tramadol), blood thinners (clopidogrel, dalteparin, enoxaparin, rivaroxaban, prasugrel, warfarin, heparin), ACE inhibitors (captopril, enalapril), calcium channel blockers (nifedipine, cilnidipine), and beta-blockers (atenolol, sotalol) due to potential interactions. Therefore, always consult your doctor before using ABCIXIREL 10MG INJECTION with other medicines.

You may begin to feel better within a few hours to a day after receiving ABCIXIREL 10MG INJECTION, as it acts quickly to prevent blood clots. However, complete improvement could take a couple of days, based on your condition. If you have any concerns regarding this, please discuss with your doctor.

ABCIXIREL 10MG INJECTION causes side effects such as bleeding, nausea, headache, abdominal pain, hypotension, vomiting, dizziness, back pain, and pain at the site of injection. However, contact a doctor if these side effect persists longer.

Country of origin

INDIA

Manufacturer/Marketer address

Dhirubhai Ambani Life Sciences Centre, R-282, TTC Area of MIDC, Thane-Belapur Road, Rabale, Navi Mumbai 400 701
Other Info - ABC0025

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:44 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/1997/abcicen110597-lab.pdf
  2. https://reference.medscape.com/drug/reopro-abciximab-342146
  3. https://www.ncbi.nlm.nih.gov/books/NBK482195/#:~:text=Abciximab%20is%20the%20Fab%20antibody,turn%20results%20in%20steric%20hindrance.
  4. https://www.sciencedirect.com/topics/agricultural-and-biological-sciences/abciximab
  5. https://www.mayoclinic.org/drugs-supplements/abciximab-intravenous-route/description/drg-20061512
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