Acgran Injection
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About Acgran Injection
Acgran Injection is a prescription medication injected to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. By blocking specific signals in the body that trigger the urge to vomit, it helps patients undergo medical treatments with greater comfort. It is typically given as a single dose shortly before your medical procedure starts.
This injection is usually given before a scheduled treatment session, so its frequency depends entirely on your medical therapy plan. Because it is given directly into a vein or muscle, there are no specific food requirements or restrictions for taking it. To help support your recovery, you can also make temporary dietary adjustments like eating dry crackers or clear broths, which help keep your stomach settled.
While Acgran Injection is generally well-tolerated, some people may experience mild side effects such as headaches or constipation. If you experience severe symptoms like chest pain, an irregular heartbeat, or signs of a serious allergic reaction, seek medical help immediately. Always consult your doctor if you experience any unexpected or bothersome symptoms during your treatment.
Before receiving this medicine, tell your doctor if you have certain health conditions, particularly heart rhythm issues or severe bowel blockages. Do not take this if you have had a severe allergic reaction to similar anti-nausea medications in the past. Your healthcare provider will evaluate whether this medicine is safe for your specific health history.
Some medicines can affect how this injection works, especially those that alter serotonin levels in your brain, which can lead to a rare but serious reaction. It is also important to tell your doctor if you are pregnant, breastfeeding, or managing other chronic health conditions before starting. Always discuss your complete medication list, including any over-the-counter supplements, with your healthcare team.
Uses of Acgran Injection
Acgran Injection is used in the treatment of Nausea and vomiting. The detailed uses of Acgran Injection are as follows:
- Chemotherapy-induced nausea and vomiting: Acgran Injection helps prevent the severe urge to vomit that often occurs shortly after or several days after receiving cancer chemotherapy drugs.
- Radiotherapy-induced nausea and vomiting: It helps protect patients undergoing whole-body or localized radiation therapy from experiencing radiation-related stomach upset.
- Post-operative nausea and vomiting: It helps prevent or treat nausea and vomiting that can occur when waking up from anesthesia after surgical procedures.
Key Benefits
Acgran Injection helps prevent nausea and vomiting, making it easier for patients to stay comfortable during cancer treatment or after surgery.
- Provides fast relief from nausea and vomiting because it is given directly into the bloodstream and starts working quickly.
- Helps prevent dehydration by reducing repeated vomiting and fluid loss.
- Protects the throat and stomach from irritation caused by frequent vomiting.
- Makes cancer treatment easier to tolerate by helping control nausea during chemotherapy or radiation therapy, allowing treatment to continue as planned.
- Supports a smoother recovery after surgery by reducing nausea and vomiting, helping protect surgical wounds and improving overall comfort.
Directions for Use
- The timing and frequency of Acgran Injection will be determined by your doctor, based on your medical condition and response to treatment.
- Acgran Injection will be administered by the doctor or healthcare professional.
- Do not self-administer.
How Acgran Injection Works
Alcohol
Caution
You are recommended to limit or avoid alcohol consumption while taking Acgran Injection. Alcohol intake, along with Acgran Injection, may lead to unwanted side effects and cause increased dizziness.
Pregnancy
Caution
It is not known if Acgran Injection affects pregnancy. Please inform your doctor if you are pregnant or planning pregnancy before receiving Acgran Injection.
Breast Feeding
Caution
It is not known if this medicine passes into breast milk. Please inform your doctor before taking Acgran Injection if you are a nursing mother.
Driving
Caution
Acgran Injection may make you feel dizzy, affecting your mental ability. Do not drive or operate machinery if you experience dizziness.
Liver
Caution
Acgran Injection should be used with caution if you have liver disease. Please inform your doctor if you have a history of liver impairment before starting Acgran Injection.
Kidney
Caution
Acgran Injection should be used with caution if you have kidney problems. Please inform your doctor if you have a history of kidney impairment/kidney disease.
Children
Caution
Safety and efficacy of Acgran Injection have not been established in children below 2 years of age.
Heart
Consult your doctor
Please consult your doctor if you have any pre-existing heart disease before using Acgran Injection.
Geriatrics
Consult your doctor
Limited information available about the use of Acgran Injection in geriatric patients. Please consult your physician.
What if I have taken an overdose of Acgran Injection
Diet & Lifestyle Advise
- Eat smaller meals: Try eating five or six small meals throughout the day instead of three large ones to avoid putting too much pressure on your stomach.
- Choose bland foods: Stick to dry, simple foods like crackers, toast, plain rice, or oatmeal, which are easy on the digestive tract.
- Stay hydrated slowly: Sip clear fluids like water, dilute broths, or electrolyte drinks slowly between meals rather than gulping them down during a meal.
- Avoid strong odors: Keep your eating area well-ventilated and avoid hot, greasy, or spicy foods that have strong smells, as these can easily trigger nausea.
- Rest upright: Avoid lying down flat for at least 30 to 60 minutes after eating or drinking to prevent acid reflux and stomach discomfort.

Have a query?
How Soon It Starts Working
The time required for Acgran Injection to start to work: The effect of Acgran Injection can be observed within 1 to 4 minutes after administration. The time for which the effects of Acgran Injection last: Acgran Injection effect lasts approximately 24 hours.
What if you forget to take Acgran Injection
Storage
Drug Warnings
- Always inspect the solution inside the vial before it is used; do not use it if you notice any cloudiness, discoloration, or floating particles.
- Ensure that all needles and syringes are disposed of immediately after a single use in a puncture-resistant sharps container.
- If you are self-injecting at home, make sure to rotate your injection sites as directed by your nurse to prevent skin irritation.
- Be cautious when rising from a sitting or lying position, as this medicine can occasionally cause mild dizziness.
- Avoid driving, operating heavy machinery, or performing tasks that require full mental alertness until you know how this medicine affects you.
- Inform any healthcare professional treating you that you are receiving Acgran Injection, especially before any new prescription is written.
Drug-Drug Interactions
Drug-Drug Interaction Summary:
- Serotonergic medications: Combining this medicine with certain antidepressants (like SSRIs or SNRIs) can increase the risk of a rare, life-threatening condition called serotonin syndrome.
- Heart rhythm medicines: Medications that affect your heart's electrical rhythm may increase the risk of irregular heartbeats when used alongside Acgran Injection.
Drug-Drug Interactions
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Taking Acgran Injection with Ziprasidone can increase the risk of abnormal heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Ziprasidone is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Taking Acgran Injection with Sparfloxacin can increase the chance of a serious abnormal heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Sparfloxacin is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
When Acgran Injection is taken with Saquinavir, can increase the risk of an irregular heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Saquinavir is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Taking Acgran Injection with mesoridazine can increase the risk of an irregular heart rhythm. I
How to manage the interaction:
Taking Mesoridazine with Acgran Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Taking Acgran Injection with Thioridazine can increase the risk of an irregular heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Thioridazine is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Taking Acgran Injection with Dronedarone can increase the risk of irregular heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Dronedarone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
Taking Acgran Injection with Pimozide can increase the risk of an irregular heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Pimozide is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
Taking Acgran Injection with Cisapride can increase the risk of an irregular heart rhythm.
How to manage the interaction:
Taking Acgran Injection with Cisapride is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking any of these drugs, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
When bupropion, is taken with Acgran Injection it can cause serotonin syndrome (a condition in which a chemical called serotonin builds up in body)
How to manage the interaction:
Co- administration of bupropion along with Acgran Injection can lead to an interaction, it can be taken if recommended by a doctor. While taking these medications if you experience, confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, a shaking sensation, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
The use of Acgran Injection and doxepin can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin builds up in body) and increase the risk of irregular heart rhythms.
How to manage the interaction:
Co-administration of Acgran Injection and Doxepin can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, diarrhea, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Drug-Food Interactions
Drug-Food Interactions
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Reference
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- Drugs.com Clinical Review Team. Granisetron Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
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- U.S. Food and Drug Administration (FDA). 020239S021,020305S014,021238S007Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
- Granisetron Granisetron. 2005. [Accessed on 28 Mar. 2018]Check here
- NIH National Library of Medicine, National center for biotechnology information. Granisetron. Pubchem. [Accessed on 26th November 2022]Check here




