Actilyse 50 mg Injection belongs to the class of thrombolytics. It is used to treat various medical conditions, including Acute Ischemic Stroke (AIS), Acute Myocardial Infarction (AMI), to reduce mortality and incidence of heart failure. Besides this, it can be used in Acute Massive Pulmonary Embolism (PE) for lysis. Acute ischemic stroke (AIS) is the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. A pulmonary embolism (PE) occurs when a clump of material, most often a blood clot, gets stuck in an artery in the lungs, blocking blood flow.

Actilyse 50 mg Injection contains Alteplase; it works by dissolving blood clots that block blood flow to the affected tissue, thereby effectively treating various medical conditions.

Actilyse 50 mg Injection is usually administered in the clinical/hospital setting under the supervision of a qualified healthcare professional. The most frequent adverse reactions of this therapy are bleeding and injection site reactions. Most of these side effects of Actilyse 50 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Before taking the Actilyse 50 mg Injection, let your doctor know about all your sensitivities and all medications you are using. And also, inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding. The presence of additional medical issues may impact the use of this medication, so inform your doctor if you have any other medical problems, including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, intracranial conditions that may increase the risk of bleeding, bleeding diathesis, current severe uncontrolled hypertension, current intracranial haemorrhage, subarachnoid haemorrhage and history of a recent stroke. It is recommended not to take alcohol while Actilyse 50 mg Injection therapy.

Actilyse 50 mg Injection plays a vital role in preventing the formation of harmful blood clots in your blood vessels. Thus, it helps to reduce the risk of Acute Ischemic Stroke (AIS) and Acute Myocardial Infarction (AMI) to reduce mortality and incidence of heart failure. On the other hand, it can treat acute massive pulmonary embolism (PE) in the lysis. It works by dissolving blood clots that block blood flow to the affected tissue.

Bleeding
Injection site reactions

Before taking the Actilyse 50 mg Injection, let your doctor know you're allergic to any ingredient. Inform your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding or if you have any other medical conditions, including active internal bleeding, recent intracranial or intraspinal surgery or serious head trauma, current severe uncontrolled hypertension, current intracranial or subarachnoid haemorrhage and history of a recent stroke.

Drug-Drug Interactions: Actilyse 50 mg Injection may interact with anticoagulant medications (e.g. warfarin, aspirin, apixaban) and angiotensin-converting enzyme inhibitors (e.g. enalapril, lisinopril).

Drug-Food Interactions: No interactions found.

Drug-Disease Interactions: Extreme caution should be used while using Actilyse 50 mg Injection in patients with bleeding risks.

• WARFARIN
• ASPIRIN
• APIXABAN
• ENALAPRIL
• LISINOPRIL

• A low-cholesterol diet and a regular exercise regime effectively complement treatment with Actilyse 50 mg Injection.
• Stick to a freshly prepared home-cooked meal and avoid processed, packed foods that contain hidden sugar and extra calories.
• Replacing most of your saturated fats with unsaturated fats can quickly reduce total cholesterol and LDL cholesterol (bad cholesterol).
• Foods like avocados, olive oil, fatty fish and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
• Include a diet enriched in fats like fish oils, polyunsaturated oils, and omega-3 fatty acids, which are good for heart health.
• Quit smoking and avoid excessive intake of alcohol.

• As Actilyse 50 mg Injection tends to increase bleeding, try to avoid injuries, keep away from sharp objects, and inform your doctor if you have peptic ulcers or injuries.

Blood clot: A blood clot can occur in any part of the body, leading to a heart attack, stroke, and organ damage (even coma or death). Blood clots can reach your arteries or veins in the organs like the brain, kidney, heart, lungs, and limbs. Conditions like atherosclerosis, diabetes, heart failure, irregular heartbeat (arrhythmia), and obesity/overweight can trigger excessive blood clotting in the brain and heart. On the other hand, deep vein thrombosis (blood clot in veins), peripheral artery disease (narrowed arteries due to fat deposit or blood clot), and atherosclerosis (fat built upon the walls of the arteries) can cause a blood clot in your limbs.

Acute Ischemic Stroke (AIS): Acute ischemic stroke (AIS) is the sudden loss of blood flow to an area of the brain with the resulting loss of neurologic function. It is caused by thrombosis or embolism that occludes a cerebral vessel supplying a specific brain area.

Acute myocardial infarction: Acute myocardial infarction is myocardial necrosis resulting from acute obstruction of a coronary artery. Symptoms include chest discomfort with or without dyspnea, nausea, and/or diaphoresis.

Acute massive pulmonary embolism (PE): A pulmonary embolism (PE) occurs when a clump of material, most often a blood clot, gets stuck in an artery in the lungs, blocking blood flow. Acute massive pulmonary embolism (PE) is defined as Acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments. Acute pulmonary emboli are accompanied by unstable hemodynamics, e.g., failure to maintain blood pressure without supportive measures.