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Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus. It contains Regular human insulin, which replaces the deficient hormone insulin in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood. It can cause some side effects such as low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin at the injection site. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

Boots Knoll Pharma

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Actrapid Hm Penfill 40I.U Injection 10 ml

Actrapid Hm Penfill 40I.U Injection 10 ml is an injectable medicine used to control high blood sugar in adults and children with diabetes mellitus. By helping your body manage glucose levels, it plays a vital role in preventing long-term complications associated with diabetes. This medicine is prescribed for both type 1 and type 2 diabetes.

To get the best results, you must inject Actrapid Hm Penfill 40I.U Injection 10 ml consistently and exactly as prescribed by your doctor. It is typically injected 30 minutes before a meal to align with your body's sugar uptake. Alongside your injections, maintaining a structured meal plan and engaging in regular physical activity are essential steps to successfully manage your blood sugar levels.

Like many diabetes medications, Actrapid Hm Penfill 40I.U Injection 10 ml can cause side effects, with low blood sugar being the most common. You may also experience mild redness, swelling, or itching around the area where you inject. If you experience severe symptoms, such as extreme confusion, sweating, a rapid heartbeat, or signs of a serious allergic reaction, seek emergency medical care immediately.

Before you begin using this medicine, talk to your doctor about your complete medical history. Do not take this if you are currently experiencing an episode of low blood sugar or if you have ever had an allergic reaction to this medicine or any of its ingredients. It is also important to tell your healthcare provider if you have kidney or liver issues or if you have heart failure.

Using Actrapid Hm Penfill 40I.U Injection 10 ml alongside other medicines, alcohol, or tobacco can affect how well it works and may increase your risk of severe low blood sugar. For example, drinking alcohol can unpredictably lower your blood sugar and mask the warning signs of hypoglycemia. Always consult your doctor if you are pregnant, planning a pregnancy, breastfeeding, or if you are caring for an elderly patient, as insulin requirements often change during these stages of life.

Uses of Actrapid Hm Penfill 40I.U Injection 10 ml

Actrapid Hm Penfill 40I.U Injection 10 ml is used to help control blood sugar levels in people with diabetes. It is commonly prescribed for: 

  • Type 1 Diabetes: Actrapid Hm Penfill 40I.U Injection 10 ml acts as a replacement for the insulin your body can no longer produce, helping to lower and manage daily blood sugar levels.
  • Type 2 Diabetes: Actrapid Hm Penfill 40I.U Injection 10 ml helps lower high blood sugar when oral diabetes medications and lifestyle modifications are not enough to keep your blood glucose within a safe range.

Key Benefits

Actrapid Hm Penfill 40I.U Injection 10 ml helps control blood sugar levels by replacing the insulin your body needs to move glucose from the bloodstream into the cells. It is particularly effective in controlling blood sugar levels around mealtimes.

  • Controls Post-Meal Blood Sugar: Helps prevent sharp increases in blood sugar after meals by acting soon after injection.
  • Maintains Blood Sugar Control: Supports healthy blood glucose levels when used regularly as part of a diabetes management plan.
  • Reduces the Risk of Diabetes Complications: Good blood sugar control helps lower the risk of complications affecting the eyes, kidneys, nerves, heart, and blood vessels.
  • Supports Daily Well-Being: Stable blood sugar levels may help improve energy levels and reduce symptoms such as excessive thirst, frequent urination, and fatigue.
  • Provides Reliable Mealtime Insulin Coverage: Helps mimic the body's natural insulin response to meals when taken as prescribed.
Side effects of Actrapid Hm Penfill 40I.U Injection 10 ml
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.

Directions for Use

Always follow your doctor's exact instructions regarding your dose and timing. Below are the standard steps for preparing and injecting Actrapid Hm Penfill 40I.U Injection 10 ml:

  • Wash your hands thoroughly with soap and water before handling your injection equipment.
  • Check the liquid inside the vial or cartridge; it must be completely clear and colourless. Do not use it if it looks cloudy, thickened, or has particles floating in it.
  • Clean the injection site on your skin (usually the stomach, thigh, upper arm, or buttocks) with an alcohol swab and let it dry.
  • Gently pinch a fold of skin, insert the needle at a 90-degree angle (or as directed by your doctor), and press the plunger to inject the dose.
  • Keep the needle under the skin for a few seconds to ensure the full dose is delivered, then pull it straight out.
  • Rotate your injection sites with every dose to keep your skin healthy and prevent lumps from forming.

How Actrapid Hm Penfill 40I.U Injection 10 ml Works

Actrapid Hm Penfill 40I.U Injection 10 ml contains ‘regular human insulin’, which is a short-acting insulin. It starts to work within 30 minutes after injection, and its action lasts up to 8 hours. It replaces the deficient hormone 'insulin' in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood.
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Alcohol

Caution

Consumption of alcohol may alter glucose levels and increase the risk of side-effects.

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Pregnancy

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used in pregnant women only if clinically needed.

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Breast Feeding

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used in breastfeeding mothers only if clinically needed.

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Driving

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml may decrease glucose levels. So, avoid driving or operating heavy machinery while using this medicine.

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Liver

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used with caution in patients with liver diseases. Your doctor may adjust the dose of this medicine before prescribing.

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Kidney

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of this medicine before prescribing.

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Children

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml is not recommended for use in children below 2 years of age. However, it can be used for the treatment of diabetes in children above 2 years of age.

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Heart

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Actrapid Hm Penfill 40I.U Injection 10 ml.

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Geriatrics

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Actrapid Hm Penfill 40I.U Injection 10 ml

An overdose of Actrapid Hm Penfill 40I.U Injection 10 ml can lead to life-threatening low blood sugar. If you inject too much, eat or drink a fast-acting source of sugar (like fruit juice, non-diet soda, or glucose tablets) immediately if you are conscious and able to swallow. Seek emergency medical attention or contact a poison control centre right away.

Diet & Lifestyle Advise

  • Maintain Consistent Carbohydrate Intake: Eat similar amounts of carbohydrates at regular mealtimes to help maintain stable blood sugar levels.
  • Carry Fast-Acting Sugar: Always keep glucose tablets, fruit juice, or hard sweets with you to treat episodes of low blood sugar.
  • Monitor Blood Sugar Regularly: Check your blood glucose before and after exercise or as advised by your doctor, since physical activity can affect insulin requirements.
  • Keep a Diabetes Record: Maintain a log of your blood sugar readings, meals, insulin doses, and physical activity to help your doctor adjust your treatment if needed.
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Have a query?

How Soon It Starts Working

The time required for Actrapid Hm Penfill 40I.U Injection 10 ml to start to work: The time required for Actrapid Hm Penfill 40I.U Injection 10 ml to start to work is 30 to 60 minutes after administration. The time for which the effects of Actrapid Hm Penfill 40I.U Injection 10 ml last: The effect of Actrapid Hm Penfill 40I.U Injection 10 ml lasts for 6 to 8 hours.

What if you forget to take Actrapid Hm Penfill 40I.U Injection 10 ml

If you miss a dose of Actrapid Hm Penfill 40I.U Injection 10 ml, check your blood sugar levels immediately. Refer to the specific backup plan provided by your doctor, or contact your healthcare provider for advice. Do not inject a double dose to make up for a missed one, as this can cause dangerously low blood sugar.

Storage

•Store unopened vials, cartridges, or pens of Actrapid Hm Penfill 40I.U Injection 10 ml in the refrigerator between 2°C and 8°C. •Do not freeze this medicine, and throw away any insulin that has been frozen.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect Before Use: Use the insulin only if it is clear, colourless, and free from particles.
  • Never Share Injection Devices: Do not share insulin pens, vials, syringes, or needles with anyone, even if the needle has been changed.
  • Rotate Injection Sites: Alternate injection sites between the abdomen, thighs, upper arms, or other recommended areas to reduce the risk of skin changes.
  • Monitor More Frequently During Special Situations: Check your blood sugar more often during illness, stress, or travel across time zones, as your insulin needs may change.
  • Verify Your Insulin Before Each Dose: Always confirm that you are using the correct type and strength of insulin before injecting to avoid medication errors.
  • Never Skip Meals After Injection: Since Actrapid Hm Penfill 40I.U Injection 10 ml is usually taken about 30 minutes before meals, eat your meal as recommended after injecting to help prevent low blood sugar. 

Drug-Drug Interactions

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Drug-Drug Interactions

Some medicines may affect how Actrapid Hm Penfill 40I.U Injection 10 ml works or increase the risk of side effects.

  • Other diabetes medications and ACE inhibitors: May increase your risk of low blood sugar when combined with Actrapid Hm Penfill 40I.U Injection 10 ml.
  • Steroids and thyroid medicines: May raise your blood sugar levels, requiring your doctor to adjust your insulin dose.
  • Beta-blockers: May hide the typical warning signs of low blood sugar, such as a fast heart rate or shakiness.

Drug-Food Interactions

Certain foods and drinks may affect how Actrapid Hm Penfill 40I.U Injection 10 ml works or increase the risk of side effects.

  • Alcohol: May lower your blood sugar levels unexpectedly and make it harder to recognise the symptoms of hypoglycemia.

Drug-Disease Interactions

Certain medical conditions may affect how Actrapid Hm Penfill 40I.U Injection 10 ml works or increase the risk of side effects. Inform your doctor if you have any of the following conditions before starting treatment.

  • Kidney or liver damage: May reduce the amount of insulin your body needs, increasing the risk of low blood sugar if the dose is not adjusted.
  • Heart failure: Taking certain diabetes medications alongside Actrapid Hm Penfill 40I.U Injection 10 ml may worsen heart failure symptoms; tell your doctor immediately if you experience shortness of breath or sudden swelling in your feet or ankles.

Drug-Drug Interactions

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How does the drug interact with Actrapid Hm Penfill 40I.U Injection 10 ml:
Coadministration of Gatifloxacin with Actrapid Hm Penfill 40I.U Injection 10 ml may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Actrapid Hm Penfill 40I.U Injection 10 ml can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised.
How does the drug interact with Actrapid Hm Penfill 40I.U Injection 10 ml:
Taking Actrapid Hm Penfill 40I.U Injection 10 ml with ciprofloxacin effects blood glucose levels, which may cause hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking ciprofloxacin and Actrapid Hm Penfill 40I.U Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor if you experience headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, increased sweating, and a rapid heartbeat, increased hunger, increased thirst. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIDIABETICS]

FAQs

Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus.
Actrapid Hm Penfill 40I.U Injection 10 ml works by increasing the glucose uptake by fats and muscles, suppresses the production of glucose in the liver, and also the formation of glycogen from glucose. These effects help in reducing the glucose levels in the blood.
In hypoglycemia, blood sugar levels decrease significantly. It causes symptoms such as dizziness, headache, sweating, hunger, loss of consciousness, rapid breathing, or seizure (fits). In such cases, seek medical attention immediately.
If you experience low blood sugar, eat glucose tablets, chocolate, or another high sugar snack such as sweet or biscuit. Use a blood glucose monitor to test your blood sugar levels after 15 minutes if possible. Eat a snack or have proper meals if the blood glucose returns to normal.
You should not change the brand of medicine or syringe without informing your doctor. It decreases blood sugar levels, so avoid driving or operating heavy machinery if you have any signs of low sugar levels. Do not take alcohol as it may worsen the health condition.
Actrapid Hm Penfill 40I.U Injection 10 ml is a short-acting human insulin used to control blood sugar levels in people with diabetes mellitus.
Typically, yes, if you have diabetes and are prescribed Actrapid Hm Penfill 40I.U Injection 10 ml, you will likely need to continue taking insulin for the rest of your life to manage your condition. However, following your healthcare provider's guidance and treatment plan is essential, as individual needs may vary.
Yes, Actrapid Hm Penfill 40I.U Injection 10 ml can be used with other diabetes medications. It is often prescribed alongside long-acting insulin or other diabetes medicines to help control blood sugar levels more effectively. However, follow your doctor's advice and treatment plan, as they will determine the best combination of medications for your specific needs.
A healthcare professional should administer Actrapid Hm Penfill 40I.U Injection 10 ml. For self-administration, inject subcutaneously 30 minutes before a meal into the thigh, upper arm, abdomen, or buttocks, rotating between these typical injection sites to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Be sure to follow your doctor's instructions regarding dosage and frequency.
Actrapid Hm Penfill 40I.U Injection 10 ml is generally considered safe to use during pregnancy. In fact, insulin is often essential for managing blood sugar levels in pregnant women with diabetes. However, it's crucial to consult with your healthcare provider to discuss the safe use of Actrapid Hm Penfill 40I.U Injection 10 ml and any potential risks or benefits during pregnancy.
Yes, Actrapid Hm Penfill 40I.U Injection 10 ml is safe to use in type 2 diabetes if used in the dose and duration your doctor advises. Keep monitoring your blood sugar levels regularly, as advised. Your dosage may need to be adjusted according to your needs. Follow the lifestyle changes advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.
The side effects of Actrapid Hm Penfill 40I.U Injection 10 ml may include redness, itching, pain, and swelling at the injection site. Rarely, repeated injections in the same area can lead to lipodystrophy, causing abnormal changes in fat tissue, such as lipohypertrophy (thickened skin) or lipoatrophy (thinned skin). To prevent these side effects, rotate injection sites within the same region to minimize the risk of lipodystrophy and ensure consistent insulin absorption.
Yes, Actrapid Hm Penfill 40I.U Injection 10 ml can cause hypoglycemia (low blood sugar), a common side effect of insulin therapy. To prevent hypoglycaemia, regularly check your blood sugar levels to detect any drops early. Keep a record of your readings and inform your doctor. Ensure you have regular meals and snacks to maintain stable blood sugar levels. Avoid skipping meals. Follow your doctor's instructions on insulin dosage. Never adjust your dose without consulting your healthcare provider.
Actrapid Hm Penfill 40I.U Injection 10 ml is typically administered subcutaneously (under the skin) in areas such as the abdomen, thigh, buttocks, or upper arm. However, it can also be given intravenously (into a vein) in specific situations like diabetic ketoacidosis or severe hyperglycaemia, but only by a healthcare professional in a hospital setting.
The dosage of Actrapid Hm Penfill 40I.U Injection 10 ml may need to be changed in various situations. This includes changes in meal patterns or physical activity, fluctuations in blood sugar levels or insulin sensitivity, or during illness or stress. Dosage adjustments may also be necessary when switching from another insulin product, during pregnancy or after delivery. It's essential to consult with your healthcare provider to determine if a dosage adjustment is necessary.
Yes, Actrapid Hm Penfill 40I.U Injection 10 ml needs to be refrigerated. It should be stored between 2°C and 8°C, but do not freeze it.
Because this is a short-acting insulin designed to match your body's response to food, it is generally best to inject it 30 minutes before your meal. Injecting it after you eat may increase the risk of a blood sugar spike followed by low blood sugar later. Talk to your doctor if you have trouble with meal timing.
You can inject this medicine into the abdomen, thighs, upper arms, or buttocks. The abdomen absorbs insulin the fastest, making it the preferred site before meals. Always rotate your injection sites to keep your skin healthy, and talk to your doctor or pharmacist about proper injection techniques.
Injecting in the exact same spot too often can cause fat deposits under the skin to clump or shrink. This can make the skin feel bumpy and, more importantly, can make your body absorb insulin unevenly, leading to unpredictable blood sugar levels. Talk to your pharmacist for tips on site rotation.
Once opened, you can keep the vial, cartridge, or pen at room temperature (below 30°C) for up to 28 days. Keep it away from direct heat and light. Do not freeze it, and do not put it back in the refrigerator once it has been kept at room temperature. Talk to your pharmacist if you have questions about storage.

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Country of origin

INDIA

Manufacturer/Marketer address

M-17, Pharma Tower, Basement & Ground Floor, Badli Industrial Area, New Delhi 110 042.
Other Info - ACT0037
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