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compositionComposition:CYCLOPHOSPHAMIDE-50MG
prescription
Prescription Medicine
info
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Adcyclo 50 Tablet is used to treat cancer and nephrotic syndrome (kidney disease). It contains Cyclophosphamide that stops the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYCLOPHOSPHAMIDE-50MG

Manufacturer/Marketer :

Adley Formulations

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Adcyclo 50 Tablet

Adcyclo 50 Tablet is a prescription medication used to treat several types of cancer, including leukaemia, lymphoma, multiple myeloma, and breast cancer. It is also prescribed to treat certain serious kidney conditions, such as nephrotic syndrome, and may be used for autoimmune diseases like lupus nephritis and vasculitis when other treatments are not suitable. It works by suppressing an overactive immune system and slowing the growth of rapidly dividing cells, helping to control disease progression and prevent further damage.

You must take Adcyclo 50 Tablet consistently at the exact times prescribed by your doctor to ensure it works effectively. It is usually taken once a day, early in the morning, and can be taken with or without food. To get the best results and protect your kidneys, it is vital to drink a large amount of fluids throughout the day while taking this medicine.

Some of the most common side effects of Adcyclo 50 Tablet include nausea, temporary hair loss, and an increased risk of catching infections. It is very important to contact your healthcare provider immediately if you experience serious side effects, such as blood in your urine, severe stomach pain, or signs of an infection like a fever.

Before you begin taking Adcyclo 50 Tablet , tell your doctor if you have kidney disease, liver damage, bladder problems, or a history of low blood cell counts. Do not take this if you currently have a severe bladder infection, active urinary tract bleeding, or if your bone marrow is severely suppressed.

This medicine can interact with several other drugs, including vaccines and medications that affect your immune system, which can increase your risk of infections. Avoid drinking alcohol while on this medication, as it can increase stomach irritation and place extra strain on your liver. If you are pregnant, planning a pregnancy, breastfeeding, or are an elderly patient, you must consult your doctor before starting this treatment.

Uses of Adcyclo 50 Tablet

Adcyclo 50 Tablet is prescribed to treat certain types of cancer and immune-related kidney disorders.

  • Certain types of cancer: Adcyclo 50 Tablet helps slow or stop the growth of abnormal cancer cells in conditions like leukaemia, lymphoma, multiple myeloma, and breast cancer.
  • Nephrotic syndrome: For severe kidney disease where the body passes too much protein in the urine, Adcyclo 50 Tablet helps by calming the overactive immune response that is damaging the kidneys.
  • Lupus nephritis: Adcyclo 50 Tablet helps suppress an overactive immune system, reducing inflammation and preventing further kidney damage in severe lupus-related kidney disease.
  • Vasculitis and other autoimmune diseases: It helps control inflammation caused by the immune system attacking blood vessels or other healthy tissues, helping prevent organ damage.

Key Benefits

Adcyclo 50 Tablet helps treat serious conditions by slowing disease progression and reducing harmful immune activity. By targeting the underlying cause of the disease, it helps improve treatment outcomes, relieve symptoms, and lower the risk of long-term complications.

  • Supports cancer treatment: Adcyclo 50 Tablet helps slow or stop the growth of abnormal cancer cells, helping shrink tumours, limit their spread, and improve the effectiveness of treatment.
  • Protects kidney function: In people with severe nephrotic syndrome, Adcyclo 50 Tablet reduces kidney inflammation and protein loss in the urine, helping relieve swelling and lower the risk of long-term kidney damage.
Side effects of Adcyclo 50 Tablet

Directions for Use

  • It is generally recommended to take Adcyclo 50 Tablet with food to prevent stomach upset or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Adcyclo 50 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Adcyclo 50 Tablet Works

Adcyclo 50 Tablet contains cyclophosphamide, which belongs to a group of medicines known as alkylating agents. It works by attaching to the DNA of rapidly dividing cells, such as cancer cells and overactive immune cells. This damages their genetic material, preventing them from growing and multiplying, eventually causing them to die. By slowing the growth of these cells, Adcyclo 50 Tablet helps control the progression of cancer and suppresses an overactive immune system, reducing damage to healthy tissues such as the kidneys in certain autoimmune and kidney disorders.
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Alcohol

Consult your doctor

It is not known if alcohol affects Adcyclo 50 Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Cyclophosphamide belongs to pregnancy category D. Adcyclo 50 Tablet should not be taken during pregnancy as it might cause fetal harm. Inform your doctor if you are pregnant, think you are pregnant or planning for pregnant.

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Breast Feeding

Unsafe

Adcyclo 50 Tablet passes into breastmilk. Avoid breastfeeding while taking Adcyclo 50 Tablet .

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Driving

Caution

Adcyclo 50 Tablet may cause dizziness. Drive or operate heavy machinery only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Adcyclo 50 Tablet should be used with caution in patients with renal impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

Adcyclo 50 Tablet should be given to children only if prescribed by a doctor.

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Heart

Caution

Adcyclo 50 Tablet should be used with caution in patients with heart problems. Inform your doctor about any heart-related conditions before taking Adcyclo 50 Tablet .

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Geriatrics

Caution

Adcyclo 50 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Adcyclo 50 Tablet .

What if I have taken an overdose of Adcyclo 50 Tablet

Taking more than the prescribed dose of Adcyclo 50 Tablet can be dangerous. In case of an accidental overdose, seek emergency medical attention immediately. An overdose may cause severe bone marrow suppression, serious gastrointestinal irritation, and other potentially life-threatening complications. Do not wait for symptoms to appear before seeking medical help.

Diet & Lifestyle Advise

  • Stay highly hydrated: Drink plenty of water and other non-caffeinated fluids throughout the day to continuously flush your bladder and reduce the risk of bladder bleeding.
  • Empty your bladder often: Urinate frequently, especially before going to bed, and do not hold your urine.
  • Avoid infections: Wash your hands frequently with soap and water, avoid crowds, and stay away from individuals who have contagious illnesses like a cold or the flu.
  • Eat cooked foods: Stick to thoroughly washed and well-cooked foods to protect your weakened immune system from foodborne bacteria.

Health Queries

I have been experiencing nephrotic syndrome for the last 13 years. What advanced treatments would you suggest?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Under the supervision of a nephrologist, advanced treatment may involve steroid-sparing immunosuppressants, depending on the kind of nephrotic syndrome. Strict blood pressure and protein control, statins, diuretics, ACE inhibitors/ARBs, and other supportive medications are also crucial.

I was diagnosed with nephrotic syndrome two years ago, with two relapses. Will Adcyclo 50 Tablet help?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Cyclosporine, or Adcyclo 50, can help avoid relapses in nephrotic syndrome, but it should only be taken as directed by a nephrologist. It is not appropriate for everyone and necessitates routine monitoring of medication levels and kidney function.

Is there any Ayurvedic treatment available for pediatric nephrotic syndrome?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Although they are primarily based on tiny case reports, Ayurvedic methods for nephrotic syndrome use herbal formulations and diet to support renal function and minimize edema. Any Ayurvedic treatment should only be used as a supplemental therapy under the careful supervision of both your child's nephrologist and a licensed Ayurvedic physician, as pediatric nephrotic syndrome is a serious medical illness. It should not be used in place of proven medical care.
health query

Have a query?

How Soon It Starts Working

The time required for Adcyclo 50 Tablet to start to work: Adcyclo 50 Tablet ideally shows its action within 2 to 4 hours after administration. The time for which the effects of Adcyclo 50 Tablet last: The effect of Adcyclo 50 Tablet lasts for 12 to 24 hours.

What if you forget to take Adcyclo 50 Tablet

If you miss a dose, take it as soon as you remember that day. If you do not remember until the next day, skip the missed dose and resume your regular schedule. Do not take two doses at the same time to make up for a missed one. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Adcyclo 50 Tablet at room temperature in a cool, dry place, away from direct sunlight, heat, and moisture.

Drug Warnings

  • Avoid Direct Contact: Caregivers should wear disposable gloves when handling Adcyclo 50 Tablet tablets or capsules, and pregnant women should avoid handling the medicine altogether.
  • Use Effective Contraception: Use reliable birth control during treatment and for the recommended period after stopping Adcyclo 50 Tablet , as it can cause serious harm to an unborn baby.
  • Avoid Live Vaccines: Do not receive live vaccines while taking Adcyclo 50 Tablet unless your doctor advises it.
  • Attend Regular Monitoring: Keep all scheduled blood and urine test appointments so your doctor can monitor your blood cell counts, kidney function, and overall response to treatment.
  • Protect Your Bladder: Adcyclo 50 Tablet may cause haemorrhagic cystitis (bleeding and inflammation of the bladder). Drink plenty of fluids and empty your bladder frequently. Some patients, especially those receiving high-dose treatment, may also be given MESNA to help protect the bladder. Ask your doctor if this applies to your treatment.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Adcyclo 50 Tablet and affect its safety or effectiveness. 

  • Immune-suppressing drugs: May increase your risk of serious infections.
  • Gout medications (like allopurinol): May increase the risk of bone marrow suppression, lowering your blood counts further.
  • Blood thinners: May change how your blood clots, requiring closer monitoring by your doctor.
CyclophosphamideNalidixic acid
Critical
CyclophosphamideCidofovir
Critical

Drug-Drug Interactions

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CyclophosphamideNalidixic acid
Critical
How does the drug interact with Adcyclo 50 Tablet:
Co-administration of Nalidixic acid with Adcyclo 50 Tablet may cause an increase in the risk of side effects.

How to manage the interaction:
Co-administration of Adcyclo 50 Tablet and Nalidixic acid can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like bruising or bleeding, unusual weakness, nausea, stomach pain, low fever, or loss of appetite, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
CyclophosphamideCidofovir
Critical
How does the drug interact with Adcyclo 50 Tablet:
Co-administration of Adcyclo 50 Tablet and Cidofovir may increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclophosphamine with Cidofovir is not recommended, please consult your doctor before taking it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm contact your doctor immediately. Do not discontinue any medications without consulting a doctor
CyclophosphamideFingolimod
Severe
How does the drug interact with Adcyclo 50 Tablet:
Taking Fingolimod's ability to suppress the immune system may be enhanced by Adcyclo 50 Tablet.

How to manage the interaction:
Although taking Adcyclo 50 Tablet and Fingolimod together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away - a serious infection, problems, high body temperature, feeling cold, loose stools, a painful throat, body discomfort, difficulty breathing, losing weight, or experiencing pain or discomfort while urinating. Do not stop using any medications without a doctor's advice.
CyclophosphamideGolimumab
Severe
How does the drug interact with Adcyclo 50 Tablet:
Co-administration of Golimumab with Adcyclo 50 Tablet may increase the risk of serious infections.

How to manage the interaction:
Co-administration of Adcyclo 50 Tablet with Golimumab can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideLevobupivacaine
Severe
How does the drug interact with Adcyclo 50 Tablet:
Co-administration of Adcyclo 50 Tablet with Levobupivacaine can increase the risk of methemoglobinemia (low level of oxygen in the blood).

How to manage the interaction:
Co-administration of Levobupivacaine with Adcyclo 50 Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. Keep a close eye on any signs or symptoms of Methemoglobinemia. If you notice any of these symptoms like gray skin, feeling sick, headaches, dizziness, tiredness, or trouble breathing, make sure to call a doctor right away. Do not stop using any medications without talking to a doctor.
CyclophosphamideRopivacaine
Severe
How does the drug interact with Adcyclo 50 Tablet:
Co-administration of Ropivacaine with Adcyclo 50 Tablet can cause methemoglobinemia (low levels of oxygen in the blood).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Adcyclo 50 Tablet, you can take these medicines together if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
CyclophosphamideLeflunomide
Severe
How does the drug interact with Adcyclo 50 Tablet:
Taking Adcyclo 50 Tablet with Leflunomide may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction, Adcyclo 50 Tablet can be taken with Leflunomide if prescribed by the doctor. Consult the doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue the medication without consulting a doctor.
CyclophosphamideCladribine
Severe
How does the drug interact with Adcyclo 50 Tablet:
The combined use of Cladribine with Adcyclo 50 Tablet can increase the risk and severity of side effects.

How to manage the interaction:
Co-administration of Cladribine with Adcyclo 50 Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, contact a doctor right away. These symptoms include complications, infection, fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not discontinue any medications without consulting a doctor.
CyclophosphamideAdalimumab
Severe
How does the drug interact with Adcyclo 50 Tablet:
When Adalimumab is taken with Adcyclo 50 Tablet, may increase the risk of serious infections.

How to manage the interaction:
Although taking Adcyclo 50 Tablet and Adalimumab together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CyclophosphamideBusulfan
Severe
How does the drug interact with Adcyclo 50 Tablet:
Co-administration of Adcyclo 50 Tablet with Busulfan can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Busulfan and Adcyclo 50 Tablet, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: May alter how your body processes this medicine, potentially increasing the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Adcyclo 50 Tablet is used to treat malignant diseases such as lymphoma (Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma, multiple myeloma, Burkitt’s lymphoma, mycosis fungoide), leukaemia, nerve tissue cancer, eye cancer, ovarian cancer, soft tissue cancer, bone cancer, and breast cancer. Additionally, Adcyclo 50 Tablet is used to treat minimal change nephrotic syndrome (kidney disease) in paediatric patients.
Adcyclo 50 Tablet is an alkylating agent that stops the growth and multiplication of cancer cells by damaging their genetic material. Thereby, Adcyclo 50 Tablet helps to treat cancer by killing the cancer cells.
Adcyclo 50 Tablet might interfere with normal wound healing. Therefore, be cautious while handling sharp objects. Consult your doctor if you notice unusual bleeding, or bruising or if the wounds do not heal properly.
No, it is not safe to father a child while taking Adcyclo 50 Tablet . Use effective contraception while taking Adcyclo 50 Tablet and for at least four months after treatment. Women of childbearing age taking Adcyclo 50 Tablet should use highly effective contraceptives while taking Adcyclo 50 Tablet up to 1 year after the treatment.
Adcyclo 50 Tablet might cause myelosuppression/bone marrow suppression leading to a decrease in white blood cells. This could lead to an increased risk of infections. Regular blood tests while taking Adcyclo 50 Tablet are advised.
During treatment with Adcyclo 50 Tablet , stay protected from sun and avoid excessive sun exposure. It’s best to use sunscreen, sunglasses and protective clothing to prevent skin damage, if your immune system is weakened.
Cancer treatments like chemotherapy and radiation therapy can increase the chance of developing other cancers, which may appear years after treatment with Adcyclo 50 Tablet . The use of Adcyclo 50 Tablet is associated with a higher risk of bladder cancer. Rarely, it may also increase the risk of other cancers like acute leukaemia, and ureter cancer.
Adcyclo 50 Tablet is a chemotherapy medicine which belongs to the class of alkylating agents. It works by destroying cancer cells.
Yes, Adcyclo 50 Tablet may be used to treat nephrotic syndrome in children, especially in cases where the condition has not improved, or has recurred after using other medications. It is also an option for children who have experienced severe side effects from other treatments. However, its safety and effectiveness for nephrotic syndrome in adults have not been established.
Adcyclo 50 Tablet may cause weight loss due to decreased appetite and may be due to underlying cancer. Consult a doctor if you experience significant weight loss.
Adcyclo 50 Tablet may cause side effects such as fever, nausea, vomiting, diarrhoea, hair loss, low blood cell count, and abdominal pain. However, if these side effects persist or worsen, please consult your doctor.
Yes. Adcyclo 50 Tablet can be taken with or without food, as directed by your doctor. If it causes stomach upset, taking it with food may help. For the best results, take it at the same time each day and follow your doctor's instructions.
Drinking plenty of water is essential because it flushes a toxic byproduct of the medicine out of your bladder, preventing severe bladder irritation and bleeding. Talk to your doctor about how much fluid is right for you.
Yes. While temporary hair loss is a common side effect of Adcyclo 50 Tablet , your hair will typically begin to grow back after you finish your treatment course. Talk to your doctor if you have concerns about hair loss.
You can usually get a standard, inactive flu shot, but you must avoid live vaccines while taking Adcyclo 50 Tablet . Always consult your doctor before getting any vaccine during your treatment.
Yes. Adcyclo 50 Tablet may affect fertility in both men and women and, in some cases, these effects may be permanent. It can interfere with sperm and egg production. If you wish to have children in the future, talk to your doctor before starting treatment about fertility preservation options such as sperm, egg, or embryo freezing.
It is highly recommended to avoid alcohol while taking Adcyclo 50 Tablet . Both alcohol and this medicine can strain your liver and irritate your stomach lining. Talk to your doctor if you have questions about alcohol use.
If you notice blood in your urine, experience pain while urinating, or have difficulty urinating, seek medical attention immediately. This is a serious side effect that requires prompt medical evaluation. Talk to your doctor right away.
Take Adcyclo 50 Tablet exactly for as long as your doctor prescribes. The duration of treatment depends on your condition, treatment response, and how well you tolerate the medicine. Do not stop taking it on your own, as this may affect your treatment. If you experience side effects or have concerns, speak to your doctor before making any changes.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 012141S090,012142S112Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Medicine Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Cyclophosphamide Oral And Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Cyclophosphamide monohydrate. 2014. [Accessed on 26 Mar. 2019]Check here
  5. Cyclophosphamide Cyclophosphamide. 1959. [Accessed on 26 Mar. 2019]Check here
  6. Baxter Healthcare Ltd. Electronic Medicines Compendium (EMC). [Revised on June 2016] [Accessed on 28th May 2022]Check here
  7. AuroMedics Pharma LLC. Cyclophosphamide. [Revised on September 2021] [Accessed on 2th May 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Adley Formulation, Sco- 42, Sector 12, Panchkula-134112, Haryana, India
Other Info - ADC0064
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