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compositionComposition:MIDODRINE-2.5MG
prescription
Prescription Medicine
info
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's
Aladrine 2.5 mg Tablet 60's

Aladrine 2.5 mg Tablet is used to treat orthostatic hypotension (sudden lowering in blood pressure on standing). It contains midodrine, which works by tightening the blood vessels, thereby increasing blood pressure. In some cases, this medicine may cause side effects such as headache, nausea, heartburn, and pain during urination. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MIDODRINE-2.5MG

Manufacturer/Marketer :

Waterley Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Aladrine 2.5 mg Tablet

Aladrine 2.5 mg Tablet belongs to a group of medicines called antihypotensives, which are used to treat low blood pressure (hypotension). Low blood pressure is when blood flow drops below normal, which can cause dizziness, weakness, fainting, and increase the risk of falls.

Aladrine 2.5 mg Tablet contains midodrine hydrochloride, which works on blood vessels through the nervous system to improve blood flow. This helps relieve symptoms like dizziness, fainting, blurred vision, and weakness when sitting or standing up.

Some people may experience supine hypertension, reflex bradycardia, arrhythmias, rash, nausea, vomiting, dyspepsia, headache, and urinary retention. Most of these side effects of Aladrine 2.5 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Aladrine 2.5 mg Tablet is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, or known hypersensitivity to any component of the product. Inform your doctor if you are a pregnant woman or nursing mother.

Uses of Aladrine 2.5 mg Tablet

Aladrine 2.5 mg Tablet is used to treat low blood pressure conditions. The detailed uses of Aladrine 2.5 mg Tablet include:

  • Treatment of idiopathic postural hypotension: Aladrine 2.5 mg Tablet helps raise blood pressure in individuals who experience a sudden drop in blood pressure upon standing (orthostatic hypotension) without a known cause.
  • Management of general hypotension: It is used to treat persistent low blood pressure that may lead to dizziness, fainting, or fatigue, by constricting blood vessels and improving blood flow.

Key Benefits

  • Aladrine 2.5 mg Tablet contains midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. 
  • Aladrine 2.5 mg Tablet helps to prevent symptoms like weakness, blurred vision, and fatigue caused by sudden drops in blood pressure.
  • Supports better daily functioning and safety by reducing the risk of falls related to low blood pressure.
Side effects of Aladrine 2.5 mg Tablet
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Wear warm clothing, especially when it's cold outside.
  • Avoid drafts and heavy air conditioning.
  • Practice to stay calm during stressful or emotional situations.
  • Apply a cream that contains urea, lactic acid, salicylic acid, or alpha-hydroxy acid to help smooth rough patches and prevent more bumps.
  • Painful urination can be reduced by drinking lots of water.
  • Don't hold urine, as it can worsen the pain during urination.
  • Try taking probiotics and eating garlic, which can help reduce painful urination.
  • Sleep well and give enough rest to your body.
  • Take a balanced diet and avoid bladder-irritating foods.
  • Quit smoking and intake of alcohol.
  • Practice yoga and meditation to improve inner strength and stay healthy.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Directions for Use

  • Aladrine 2.5 mg Tablet can be taken with meals.
  • It is usually taken 2-3 times daily during the daytime, with each dose taken 3 hours apart, or as prescribed by your doctor.
  • Swallow Aladrine 2.5 mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Aladrine 2.5 mg Tablet Works

Aladrine 2.5 mg Tablet contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.
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Alcohol

Unsafe

Consuming alcohol along with Aladrine 2.5 mg Tablet is not advisable as it may cause unpleasant side effects.

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Pregnancy

Consult your doctor

Please consult the doctor. There are no adequate and well-controlled studies on pregnant women.

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Breast Feeding

Consult your doctor

Consult your doctor, and there is no substantial research yet on the use of Aladrine 2.5 mg Tablet in breastfeeding/nursing mothers.

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Driving

Unsafe

If you feel dizzy or lightheaded while taking Aladrine 2.5 mg Tablet , avoid driving or using machines.

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Liver

Consult your doctor

Limited information is available on the use of Aladrine 2.5 mg Tablet in patients with liver disease. Please consult your doctor.

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Kidney

Consult your doctor

Limited information is available on the use of Aladrine 2.5 mg Tablet in patients with Kidney disease. Please consult your doctor.

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Children

Unsafe

Aladrine 2.5 mg Tablet is not recommended for children below 18 years of age.

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Heart

Unsafe

Aladrine 2.5 mg Tablet is contraindicated in patients with heart conditions. Please seek medical advice before using this medicine.

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Geriatrics

Caution

Aladrine 2.5 mg Tablet should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using Aladrine 2.5 mg Tablet in geriatrics, please consult your doctor.

What if I have taken an overdose of Aladrine 2.5 mg Tablet

Take Aladrine 2.5 mg Tablet only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to serious side effects such as palpitations, headache, pounding in the ears, goose bumps, blurred vision, difficulty urinating, and cold sensation. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Diet & Lifestyle Advise

  • Add foods with high vitamin B12, including eggs, fortified cereals, and nutritional yeast, to your daily diet.
  • Salty foods can increase blood pressure. Try eating canned soup, cottage cheese, olives, and pickled items.
  • Drink coffee and caffeinated tea, which may increase blood pressure by stimulating the cardiovascular system.
  • Eat small meals more frequently; large meals may drop in blood pressure as your body works harder to digest larger meals.
  • Drink more water and limit alcohol; dehydration lowers blood pressure.
  • Change body position by standing up slowly.
  • Avoid prolonged bed rest.
  • If you exercise outdoors in extreme heat, take frequent breaks.
  • Avoid spending a long time in saunas, hot tubs, and steam rooms, which cause dehydration.

Have a query?

How Soon It Starts Working

  • The time required for Aladrine 2.5 mg Tablet to start to work: The time required for Aladrine 2.5 mg Tablet to show its action is unknown. 
  • The time for which the effects of Aladrine 2.5 mg Tablet last: Aladrine 2.5 mg Tablet effect lasts for 24 hours.

What if you forget to take Aladrine 2.5 mg Tablet

Take the missed dose as soon as you remember, provided it is at least 4 hours before bedtime. However, if it is time for your next dose, skip the missed dose and follow your regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight.• Keep Aladrine 2.5 mg Tablet out of the sight and reach of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • If you are known to be allergic to Aladrine 2.5 mg Tablet or any other medicines, please tell your doctor.
  • If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.
  • Aladrine 2.5 mg Tablet should not be used by children below 18 years.
  • Aladrine 2.5 mg Tablet is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, pheochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, and hyperthyroidism.
  • Inform your doctor if you have a history of stroke (CVA); close monitoring may be needed.
  • Avoid driving or operating heavy machinery if you feel dizzy or lightheaded.
  • Do not stop taking Aladrine 2.5 mg Tablet suddenly without consulting your doctor.
  • Aladrine 2.5 mg Tablet can cause high blood pressure when lying down, so regular blood pressure checks are important.

Drug-Drug Interactions

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Drug-drug interactions: Aladrine 2.5 mg Tablet may interact with drugs used to treat depression and anxiety (e.g. duloxetine), medicines used to help control the amount of sodium and fluids in your body (e.g. fludrocortisone), and medications used to treat high blood pressure (e.g. metoprolol).

Drug-food interactions: Consuming alcohol with Aladrine 2.5 mg Tablet is not advisable as it may cause unpleasant side effects.

Drug-disease interactions: Aladrine 2.5 mg Tablet should be used with caution in patients with heart disease/ hypertensive effects, kidney or liver dysfunction and diabetes.

MidodrineDihydroergotamine
Critical
MidodrineMethysergide
Severe

Drug-Drug Interactions

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MidodrineDihydroergotamine
Critical
How does the drug interact with Aladrine 2.5 mg Tablet:
Coadministration of Dihydroergotamine with Aladrine 2.5 mg Tablet can increase the risk or severity of high blood pressure.

How to manage the interaction:
Taking Dihydroergotamine with Aladrine 2.5 mg Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any of these symptoms like headaches, abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, eye redness, confusion, or slurred speech, consult a doctor right away. Do not discontinue any medications without consulting a doctor.
MidodrineMethysergide
Severe
How does the drug interact with Aladrine 2.5 mg Tablet:
Using methysergide maleate together with Aladrine 2.5 mg Tablet may cause significant increases in blood pressure.

How to manage the interaction:
Co-administration of Aladrine 2.5 mg Tablet with Methysergide can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medications without first consulting a doctor.
MidodrineErgotamine
Severe
How does the drug interact with Aladrine 2.5 mg Tablet:
Using ergotamine together with Aladrine 2.5 mg Tablet can increase the risk or severity of high blood pressure.

How to manage the interaction:
There may be a possibility of interaction between Aladrine 2.5 mg Tablet and Ergotamine, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discolouration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
MidodrineIobenguane (131i)
Severe
How does the drug interact with Aladrine 2.5 mg Tablet:
Coadministration of Aladrine 2.5 mg Tablet with Iobenguane can cause a decrease in the absorption of Iobenguane resulting in a low treatment outcomes.

How to manage the interaction:
Co-administration of Aladrine 2.5 mg Tablet with Iobenguane (131i) can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without a doctor's advice.
MidodrineLinezolid
Severe
How does the drug interact with Aladrine 2.5 mg Tablet:
Taking Aladrine 2.5 mg Tablet along with linezolid could increase the risk or severity of high blood pressure.

How to manage the interaction:
Although taking linezolid with Aladrine 2.5 mg Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience abdominal pain, nausea, vomiting, numbness or tingling, muscle pain or weakness, blue or purple discoloration of fingers or toes, pale or cold skin, chest pain or tightness, severe or throbbing headache, irregular heartbeat, shortness of breath, blurred vision, confusion, and/or slurred speech, contact a doctor immediately. Do not discontinue any medication without consulting a doctor.
MidodrineDoxapram
Severe
How does the drug interact with Aladrine 2.5 mg Tablet:
Coadministration of Aladrine 2.5 mg Tablet with doxapram can increase effect of Doxapram.

How to manage the interaction:
Taking Doxapram with Aladrine 2.5 mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

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Therapeutic Class

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FAQs

Aladrine 2.5 mg Tablet is used to treat idiopathic postural hypotension or hypotension (low blood pressure)
Aladrine 2.5 mg Tablet contains the active ingredient midodrine hydrochloride, which acts on the blood vessels via the sympathetic nervous system to correct imbalances of blood distribution. This should help relieve the symptoms you might suffer, such as dizziness, fainting, blurred vision, and weakness when sitting or standing up.
Do not stop taking Aladrine 2.5 mg Tablet on your own. Depending on your medical condition, you are advised to take Aladrine 2.5 mg Tablet for as long as your doctor has prescribed it for you. Do not hesitate to speak with your doctor if you experience difficulty while taking Aladrine 2.5 mg Tablet .
Aladrine 2.5 mg Tablet is contraindicated in patients with severe organic heart disease, congestive heart failure, thyrotoxicosis, phaeochromocytoma, acute renal disease, severe renal insufficiency, urinary retention, narrow-angle glaucoma, hyperthyroidism, known hypersensitivity to any component of the product. And also, Patients with a history of CVA should be monitored closely.
Aladrine 2.5 mg Tablet is metabolised to desglymidodrine, an active metabolite that activates alpha-1-adrenergic receptors on arterioles and venules, causing smooth muscle contraction and blood pressure increase. Midodrine may cause a drop in heart rate due to the vagal reflex.
The side effects of Aladrine 2.5 mg Tablet include nausea, vomiting, indigestion, supine hypertension (high blood pressure while lying down), and dysuria (painful or uncomfortable urination). If these side effects persist or worsen, please consult your doctor.
Yes, Aladrine 2.5 mg Tablet may cause high blood pressure when you are lying flat on your back (supine hypertension). Aladrine 2.5 mg Tablet should only be used by people whose low blood pressure affects their daily activities and in people who could not be treated successfully with other therapies.
You are advised not to lie down immediately after taking Aladrine 2.5 mg Tablet due to the risk of supine hypertension (high blood pressure when you are lying flat on your back). Therefore, it is recommended to take the final dose of the day at least 4 hours before bedtime. By elevating the head, you can reduce the risk of supine hypertension during the night.
Aladrine 2.5 mg Tablet may take about 1 hour to show its effects. Though the effect lasts for about 2-3 hours, the action lasts for a short time only.
Take Aladrine 2.5 mg Tablet exactly as advised by your doctor. It is taken orally with or without food. Swallow it as a whole with a glass of water. Do not break, crush or chew it.
Aladrine 2.5 mg Tablet is not recommended for patients who are allergic to any of its components, who have unusually slow heart rate, severe heart disease, high blood pressure, conditions causing tightening of the arteries, urinary retention (when the bladder cannot empty properly), overactive thyroid, enlarged prostate gland, pheochromocytoma (tumour of the adrenal medulla), acute or severe kidney disease, poor vision as a result of diabetes and narrow-angle glaucoma (elevated pressure in the eye).
Before starting Aladrine 2.5 mg Tablet , you may need to get your liver and kidney function tests done and check your blood pressure. After starting the treatment, keep a constant track of your heart rate and blood pressure, especially after lying down.
Symptoms of supine hypertension include shortness of breath, chest pain, palpitations (abnormalities of heartbeat), blurred vision, and headache. If you develop these symptoms, consult your doctor immediately. The doctor may lower the dose of Aladrine 2.5 mg Tablet or discontinue treatment if the symptoms persists.
You should be cautious while using Aladrine 2.5 mg Tablet and metoprolol together as it can decrease your heart rate significantly. If you experience dizziness, fainting and slow pulse, inform your doctor as the dose of these medicines may need to be adjusted. However, please consult your doctor before using other medicines with Aladrine 2.5 mg Tablet .

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. National Health Service (NHS). Midodrine Information Leaflet - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Electronic Medicines Compendium (EMC). Pil.12496 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Drugs.com Clinical Review Team. Midodrine Drug Interactions Reference. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  5. Midodrine hydrochloride [Product Information]. 2023. [Accessed on 05 Mar. 2025] Check here
  6. Midodrine Hydrochloride [Product Information]. 2024. [Accessed on 05 Mar. 2025] Check here
  7. Midodrine 2.5 Tablets - Patient Information Leaflet (PIL) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 13 June 2025]Check here

Country of origin

India

Manufacturer/Marketer address

1st Floor, H.No.9-7-211/23-24, Green View Enclave, Beside Mansarovar Heights, Phase-I, Hasmathpet, Secunderabad, Hyderabad, Telangana, 500009
Other Info - ALA0087

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