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compositionComposition:VINCRISTINE-1MG
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Alcrist 1mg Injection is an anti-cancer drug used to treat various types of cancer such as cancer of the breast, pancreas, kidney, blood, bone and lung. It contains Vincristine, which stops the further growth and multiplication of the cancer cells. It may cause side effects such as hair loss, constipation, headache, tingling and numbness of feet and hand, stomach cramps, feeling tired or weak, back, bone, joint, or muscle pain, mouth irritation, or mouth sores.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VINCRISTINE-1MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Alcrist 1mg Injection

Alcrist 1mg Injection is an injection used as part of chemotherapy to treat various types of cancers, such as blood cancers and tumours in the lymph nodes. It works to stop abnormal cells from rapidly multiplying, which is key to managing these progressive conditions. Your medical team will determine if this medication is the right option for your specific diagnosis.


Because this medicine is given as a parenteral injection directly into a vein, it is administered on a highly structured schedule by a trained healthcare professional. Staying consistent with your clinical appointments is crucial for the treatment to work effectively. While undergoing therapy, making certain changes to your diet, such as drinking more fluids and eating fibre-rich foods, can help manage some of the challenges that come with this medicine.


While Alcrist 1mg Injection is highly effective, it can cause common side effects like temporary hair loss, mild nerve tingling, or stomach upset. It is very important to contact your doctor immediately if you notice more severe issues, such as sudden and severe constipation, difficulty walking, or pain at the site where the medicine was injected.


Before starting your treatment, it is vital to discuss your full medical history with your doctor, especially if you have a history of nerve disorders or liver damage. Do not take this if you have certain inherited nerve disorders, such as Charcot-Marie-Tooth syndrome, as this medicine can cause severe, irreversible nerve damage in these individuals.


Alcrist 1mg Injection can interact with several substances, including certain anti-seizure drugs and antifungals, which might change how well your treatments work or increase side effects. Always consult your doctor if you are pregnant, breastfeeding, or if the patient is an older adult, as specialised care plans may be required for these groups.

Uses of Alcrist 1mg Injection

Your doctor may prescribe Alcrist 1mg Injection for several serious conditions, often alongside other chemotherapy medications:

  • Acute Lymphocytic Leukaemia (ALL): Alcrist 1mg Injection helps stop the rapid growth of abnormal white blood cells in the bone marrow and blood.
  • Hodgkin's and Non-Hodgkin's Lymphoma: It targets and destroys cancerous cells in the lymphatic system to help bring the disease into remission.
  • Wilms' Tumour: This medicine is used to treat this specific type of kidney cancer that primarily occurs in children.
  • Neuroblastoma: It works to manage this nerve tissue cancer that typically starts in the adrenal glands.
  • Rhabdomyosarcoma: Alcrist 1mg Injection helps slow the growth of cancerous cells in the body's soft tissues, such as skeletal muscle.

Key Benefits

Alcrist 1mg Injection is a chemotherapy medicine used as part of treatment regimens for several types of cancer. It works by disrupting the process cancer cells need to divide and multiply, helping control disease progression.

  • Controls Cancer Cell Growth: Stops rapidly dividing cancer cells from completing cell division, which helps limit their growth and multiplication.
  • Supports Treatment of Different Cancers: Used in combination chemotherapy regimens for certain blood cancers and solid tumours, depending on the diagnosis and treatment plan.
  • Helps Reduce Cancer Burden: By controlling cancer cell multiplication, it may help shrink some tumours or reduce the number of cancer cells in the body.
  • Supports Remission: When used as part of an appropriate combination chemotherapy regimen, Alcrist 1mg Injection may contribute to achieving and maintaining remission in certain cancers. Treatment outcomes vary according to the cancer type, stage, overall health, and response to therapy.
  • Complements Combination Chemotherapy: Works through a different mechanism from many other anticancer medicines, allowing it to be combined with other treatments that target cancer cells in different ways.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Alcrist 1mg Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Alcrist 1mg Injection Works

Alcrist 1mg Injection contains vincristine, an anticancer medicine that belongs to a class of drugs known as vinca alkaloids. It targets cells that are dividing rapidly, a key characteristic of cancer cells. Inside cells, there are tiny structural proteins called tubulin. These proteins join together to form a 'scaffold' known as microtubules that the cell needs to split and divide into two new cells. Alcrist 1mg Injection works by binding to these tubulin proteins and stopping the scaffold from forming. Without this structure, the cancer cell cannot complete its division process and eventually self-destructs. Because normal cells divide much more slowly than cancer cells, this treatment primarily impacts the rapidly dividing cancer cells.
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Alcohol

Caution

Avoid consumption of alcohol while taking Alcrist 1mg Injection as it may increase drowsiness.

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Pregnancy

Unsafe

Alcrist 1mg Injection is a pregnancy category D drug. It should not be used in pregnancy as it is known to cause fetal damage. Also, maintain a gap of 6 months between the last dose of Alcrist 1mg Injection and your next pregnancy.

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Breast Feeding

Unsafe

Alcrist 1mg Injection is known to pass through breast milk and it may cause harm to the baby. So, it is advised not to breastfeed while taking Alcrist 1mg Injection.

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Driving

Unsafe

Alcrist 1mg Injection may cause weakness, dizziness and drowsiness. Do not drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

The safety and efficacy of Alcrist 1mg Injection are not known in children. It should be taken only if prescribed by a doctor.

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Heart

Unsafe

This medicine is not recommended for cardiac patients due to its adverse effects.

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Geriatrics

Caution

Alcrist 1mg Injection should be administered with caution in geriatric patients.

What if I have taken an overdose of Alcrist 1mg Injection

An overdose is highly unlikely because your medical team carefully calculates and administers the dose in a controlled medical environment. If you suspect an error has occurred or if you experience severe side effects immediately after your injection, tell your healthcare provider right away or seek emergency medical attention.

Diet & Lifestyle Advise

  • Prevent severe constipation: This medicine can significantly slow down your bowels. Eat a high-fibre diet rich in fruits, vegetables, and whole grains, and drink plenty of fluids daily. Ask your doctor if you should start a preventive stool softener.
  • Manage nerve sensitivity: Since this medicine can affect your nerves, be cautious when handling hot or sharp objects. Wear supportive, flat shoes to help maintain your balance if you experience numbness in your feet.
  • Protect against infections: Your body's defences may be lowered during treatment. Wash your hands frequently, avoid large crowds, and stay away from people who are actively sick. Avoid eating raw or undercooked foods.
  • Use gentle self-care products: Use a soft-bristled toothbrush to protect your gums from bleeding, and apply a mild moisturiser to care for sensitive skin.
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How Soon It Starts Working

The time required for Alcrist 1mg Injection to start to work: The time required for Alcrist 1mg Injection to show its action is unknown. The time for which the effects of Alcrist 1mg Injection last: The duration of action for Alcrist 1mg Injection is unknown.

What if you forget to take Alcrist 1mg Injection

Because this medicine is injected by a healthcare professional in a clinic, a missed dose is unlikely. However, if you miss an appointment for your scheduled injection, contact your clinic or doctor immediately to reschedule. Do not wait until your next scheduled visit to report the missed appointment.

Storage

•Under normal circumstances, Alcrist 1mg Injection is stored and prepared directly by the hospital or clinic pharmacy. •It must be stored in a refrigerator between 2°C and 8°C (36°F to 46°F).

Drug Warnings

  • Intravenous use only: This medicine must only be injected into a vein. Injection into the spinal fluid (intrathecal) is fatal and must never be done.
  • Monitor the injection site closely: Tell your nurse immediately if you feel any burning, stinging, or pain while the injection is being given. If the drug leaks outside the vein, it can cause severe tissue damage.
  • Track your bowel movements: Keep a daily log of your bowel movements. Notify your doctor right away if you go more than two days without a bowel movement or experience abdominal pain.
  • Report nerve changes early: Let your medical team know if you have trouble with fine tasks, like buttoning a shirt or picking up small items, as this could be an early sign of nerve damage.
  • Avoid live vaccines: Do not receive any live vaccines while undergoing treatment, as your weakened immune system may not react safely.

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with Alcrist 1mg Injection:

  • Anti-seizure medications (like phenytoin): Alcrist 1mg Injection can lower the level of these medicines in your blood, which may increase your risk of having a seizure.
  • Antifungals (like itraconazole or ketoconazole): These medicines can slow down how your liver processes Alcrist 1mg Injection, increasing the drug's levels in your body and raising the risk of severe nerve damage.
  • Other chemotherapy drugs: Combining this medicine with other cancer treatments can increase the risk of low blood cell counts and nerve complications.

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verifiedApollotooltip

Certain foods and drinks may affect how Alcrist 1mg Injection is processed by the body and increase the risk of side effects. Important interactions include:

  • Grapefruit and grapefruit juice: Grapefruit can interfere with how your body breaks down Alcrist 1mg Injection, which can lead to higher levels of the drug in your body and worse side effects.

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Alcrist 1mg Injection is used to treat various types of cancer. It is used to treat cancer of the breast, pancreas, kidney, blood, bone, lung.
Alcrist 1mg Injection contains Vincristine, which works by blocking DNAÂ replication (genetic material) in the cancer cells. Hence, this stops the further growth and multiplication of the cancer cells.Â
Alcrist 1mg Injection if not administered properly, and if it leaks from the vein, it may cause tissue damage. So, if you see any redness, pain, swelling, burning, skin sores or leaking of fluid from where the drug is going into your body, please tell your nurse.
The most common side effects of Alcrist 1mg Injection are hair loss, constipation, headache, peripheral neuropathy (tingling and numbness of feet and hand), stomach cramps, feeling tired or weak, back, bone, joint or muscle pain, mouth irritation or mouth sores​​​​​​​. Most of these side-effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.Â
Alcrist 1mg Injection is a vesicant (irritant) and can damage the tissues and blood vessels if it is not administered correctly, which can be fatal. So, it should be given by a trained professional in the hospital.
Yes, Alcrist 1mg Injection is a cytotoxic (toxic to living cells) medicine. So, it is advised to be very cautious while taking Alcrist 1mg Injection.
This medicine is injected strictly into a vein (intravenously) by a trained healthcare professional in a hospital or clinic setting. It must never be given by any other route, as doing so can be life-threatening. Talk to your doctor if you want to understand more about your infusion process.
No, Alcrist 1mg Injection can harm an unborn baby. Both men and women should use highly effective birth control during treatment and for a specified time after therapy ends. Talk to your doctor if you are planning a family or have questions about fertility.
You should avoid receiving live vaccines during your treatment, as Alcrist 1mg Injection can lower your immune system and make the vaccine unsafe. Always talk to your doctor or pharmacist before getting any immunisations.
It is highly recommended to avoid alcohol while receiving this medication, as alcohol can place extra stress on your liver and worsen dehydration, which can make constipation and nerve symptoms worse. Talk to your doctor before consuming alcohol during your treatment cycle.

Disclaimer

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Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ALCR933
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