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compositionComposition:ALPRAZOLAM-0.5MG+SERTRALINE-25MG
prescription
Prescription Medicine
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Alprax Plus Tablet is used to treat panic disorder. It contains Alprazolam and Sertraline, which increase the activity of certain messengers and hormones that help improve mood, relax muscles, and produce a calming effect. In some cases, this medicine may cause side effects such as nausea, increased appetite, restlessness, drowsiness, dizziness, headache, constipation, and dry mouth. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ALPRAZOLAM-0.5MG+SERTRALINE-25MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Alprax Plus Tablet

Alprax Plus Tablet is prescribed to help manage conditions involving both depression and severe anxiety. Its medical purpose is to restore the balance of certain natural chemicals in the brain to relieve persistent worry, panic, and low mood. By targeting these brain chemical imbalances, this medicine helps stabilise your emotional state and supports everyday functioning.

To achieve the best results, it is important to take Alprax Plus Tablet consistently at the same time every day as directed by your healthcare provider. You can take this medication with or without food. Combining your treatment with healthy lifestyle adjustments, such as maintaining a regular sleep schedule, engaging in moderate physical activity, and practising relaxation techniques, can further support your progress.

While taking Alprax Plus Tablet , you may experience common, mild side effects like drowsiness, dry mouth, or changes in appetite. However, you must contact your doctor immediately if you notice serious symptoms, such as severe mood shifts, extreme confusion, or signs of an allergic reaction. Monitoring how you feel can help your doctor ensure you are on the right track.

Before starting this medication, Talk to your doctor if you have glaucoma or a history of increased pressure in the eyes, particularly narrow-angle glaucoma, kidney issues, or liver damage. Do not take this if you have severe breathing difficulties, muscle weakness, or a known allergy to any active ingredient in the formulation. Your doctor will determine if this treatment is safe for your specific health history.

This medicine can interact with other substances, including alcohol, which can cause extreme drowsiness and dangerously slow your breathing. Always consult your doctor before starting Alprax Plus Tablet if you are pregnant, planning a pregnancy, breastfeeding, or are an older adult, as these situations require careful medical guidance. This medicine is not routinely recommended for children or adolescents unless specifically prescribed by a specialist. Dose adjustments and closer monitoring may also be required in people with liver disease, kidney impairment, or those taking multiple medicines.

This fixed-dose combination is prescribed in selected clinical situations based on your symptoms, diagnosis, and treatment needs. Your doctor will determine whether this combination medicine is appropriate for your condition and adjust your treatment accordingly. 

Uses of Alprax Plus Tablet

Your doctor may prescribe Alprax Plus Tablet for several clinically recognised conditions. These include:

  • Depression: Sertraline helps lift your mood, restore interest in daily life, and reduce persistent feelings of sadness and emptiness.
  • Anxiety disorders: Alprazolam provides rapid relief from excessive worry, physical tension, and ongoing fear that interfere with daily tasks.
  • Panic disorder: The combined effects of these active ingredients help reduce the frequency and intensity of sudden, unexpected panic attacks.

Key Benefits

Alprax Plus Tablet offers comprehensive support for individuals managing complex mood and anxiety symptoms. It works to bring real-world relief by improving how you feel day-to-day.

  • Dual-action relief: It addresses both anxiety and depression simultaneously, providing a more balanced approach to managing your overall mental health.
  • Rapid calming effect: The alprazolam component provides relatively quick relief from acute anxiety and panic symptoms while the sertraline component works gradually to provide longer-term symptom control.
  • Improved sleep quality: By reducing constant worry and muscle tension, this medication helps make it easier to fall asleep and stay asleep throughout the night.
  • Restored daily functioning: Over time, the mood-stabilising effects help you re-engage in work, hobbies, and social interactions with greater ease.
Side effects of Alprax Plus Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Blood flow to the brain and the rest of the body is increased by physical activity. This could help you maintain your memory.
  • Reading, solving puzzles, and picking up new skills are examples of mental workouts that can keep the brain engaged and enhance memory retention.
  • Maintaining an active social life enhances memory and brain stimulation.
  • Relaxation methods like yoga, meditation, and deep breathing can help because long-term stress can affect memory.
  • Chest pain may last for a while and needs immediate medical attention as it is a significant health issue to be attended to.
  • Take rest and refrain from doing physical activity for a while, and restart after a few days.
  • Try applying an ice pack to the strained area for at least 20 minutes thrice a day. Ice pack thus helps reduce inflammation.
  • Sit upright and maintain proper posture if there is persistent chest pain. • Use extra pillows to elevate your position and prop your chest up while sleeping.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Avoid trigger foods that can cause allergic reactions, such as nuts, shellfish, or dairy products.
  • Keep a food diary to track potential food allergens.
  • Include omega-3 rich foods like salmon and walnuts to reduce inflammation.
  • Wear loose, comfortable clothing made from soft fabrics like cotton.
  • Apply cool compresses or take cool baths to reduce itching.
  • Use gentle soaps and avoid harsh skin products.
  • Reduce stress through relaxation techniques like meditation or deep breathing.

Directions for Use

  • Take Alprax Plus Tablet with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Alprax Plus Tablet Works

Alprax Plus Tablet contains two active components that work in different, complementary ways in your brain to help regulate your mood and lower anxiety. The first active component is sertraline, which belongs to a class of medicines called Selective Serotonin Reuptake Inhibitors (SSRIs). It works by raising the levels of serotonin, a natural chemical messenger in the brain. Serotonin plays a key role in maintaining emotional balance, helping to lift your mood and reduce persistent feelings of sadness. The second active component is alprazolam, which belongs to a class of medicines called benzodiazepines. It works by boosting the effects of a natural calming chemical in the brain known as gamma-aminobutyric acid (GABA). By enhancing GABA, it helps slow down excessive brain activity, providing quick relief from acute tension, nervousness, and panic. Alprazolam may help relieve anxiety symptoms relatively quickly, whereas the antidepressant effects of sertraline usually become noticeable over several weeks, with full benefit often taking 4 to 8 weeks or longer. Continue taking the medicine exactly as prescribed, even if you do not feel better immediately.
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Alcohol

Unsafe

Alprax Plus Tablet interacts with alcohol and increases the risk of side-effects such as drowsiness and dizziness.

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Pregnancy

Unsafe

Alprax Plus Tablet is a category C medicine. It may cause harmful effects to the unborn baby when used in pregnant women.

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Breast Feeding

Unsafe

Alprax Plus Tablet may pass into breastmilk and may cause harmful effects to the nursing baby when used in breastfeeding mothers.

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Driving

Unsafe

Alprax Plus Tablet may cause drowsiness and dizziness. So, it is recommended to avoid driving or operating heavy machinery if you are not fully alert.

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Liver

Caution

Alprax Plus Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor as required.

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Kidney

Caution

Alprax Plus Tablet should be used with caution in patients with kidney problems. The dose may have to be adjusted by your doctor as required.

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Children

Unsafe

Alprax Plus Tablet is not recommended for use in children as the safety and efficacy have not been established.

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Heart

Caution

Limited data is available regarding the use of Alprax Plus Tablet in patients with heart problems. Please consult your doctor if you have any concerns regarding this.

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Geriatrics

Caution

Alprax Plus Tablet should be given with caution in elderly patients due to an increased risk of side effects. It is important to inform your doctor before using it.

What if I have taken an overdose of Alprax Plus Tablet

If you suspect an overdose, seek immediate medical attention or contact emergency medical services right away. Symptoms of an overdose can include extreme drowsiness, confusion, slowed breathing, slurred speech, or loss of consciousness

Diet & Lifestyle Advise

Incorporate these practical, evidence-based tips to help support your treatment and stay safe while taking Alprax Plus Tablet :

  • Avoid alcohol completely: Alcohol interacts negatively with this medicine, heavily increasing sleepiness, dizziness, and the risk of dangerous breathing difficulties.
  • Limit your caffeine intake: High amounts of caffeine from coffee, soda, or energy drinks can worsen anxiety and counter the calming effects of this medication.
  • Establish a regular sleep routine: Going to bed and waking up at the same time each day helps stabilise your mood and complements the benefits of your therapy.
  • Stay physically active: Light, regular exercise like walking, swimming, or yoga can naturally boost your mood and help reduce muscle tension.
  • Keep a daily symptom log: Note how you feel each day so you can discuss your progress and any changes with your doctor or pharmacist.

Health Queries

Can I purchase Alprax Plus Tablet online for my own use?

Bayyarapu Mahesh Kumar

Bayyarapu Mahesh Kumar

M Pharmacy

Alprax Plus Tablet is a controlled prescription medication and should be used only if it has been prescribed to you for a specific medical condition. It contains Alprazolam and Sertraline. Due to strict regulations by the Government of India and health authorities, it is not available for online sale. It is dispensed only against a valid doctor’s prescription through licensed pharmacies. Due to regulatory restrictions, availability may be limited in retail medical stores, and it is more commonly accessible through hospital pharmacy counters where it has been prescribed.

I have stress-related stomach pain and digestive problems. How can I treat them?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Manage stress with relaxation techniques such as deep breathing, meditation, or yoga, and maintain a regular exercise routine and good sleep. Avoid spicy, fatty, or very acidic foods, eat smaller, more frequent meals, and limit caffeine and alcohol. If symptoms persist or worsen, consult your doctor for possible medications or further tests.
health query

Have a query?

How Soon It Starts Working

The time required for Alprax Plus Tablet to start to work: The time required for Alprax Plus Tablet to show its action is unknown. The time for which the effects of Alprax Plus Tablet last: The duration of action for Alprax Plus Tablet is clinically unknown.

What if you forget to take Alprax Plus Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store the tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original container to protect it from moisture and direct light. Do not store it in the bathroom.

Drug Warnings

  • Do not drive or operate machinery: Because this medicine causes drowsiness and slows your reaction times, avoid driving or performing dangerous tasks until you are sure how it affects you.
  • Do not stop taking it suddenly: Stopping abruptly can cause severe withdrawal, including extreme anxiety, tremors, sweating, and sleep issues. Your doctor will help you gradually taper the dose before stopping treatment to reduce the risk of withdrawal symptoms. Never stop this medicine suddenly without medical advice.
  • Avoid other sedating substances: Talk to your doctor before taking any other prescription or over-the-counter medicines that cause drowsiness, such as allergy pills or cold remedies.
  • Check the packaging: Inspect your tablets before taking them. Do not use them if the packaging is torn, damaged, or if the tablets show signs of discolouration.
  • Inform all healthcare providers: Ensure any doctor, dentist, or specialist you see knows that you are currently taking Alprax Plus Tablet .
  • Monitor for mood changes: Sertraline may increase the risk of suicidal thoughts or behaviour, particularly in children, adolescents, and young adults during the first few weeks of treatment or after a dose change. Seek medical attention immediately if you or your family notice worsening depression, unusual behaviour changes, agitation, or thoughts of self-harm.
  • Use alprazolam only as prescribed: The alprazolam component is generally intended for short-term use (typically up to 2 to 4 weeks) to relieve anxiety symptoms while sertraline begins to take effect. Your doctor will regularly review whether ongoing treatment is necessary and determine if continued use is appropriate. 

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with this medicine and affect its safety or effectiveness:

  • Monoamine Oxidase Inhibitors (MAOIs): Do not take this medicine with or shortly after taking MAOIs, as this can cause a life-threatening spike in serotonin levels (serotonin syndrome).
  • Other central nervous system depressants: Taking this medicine with prescription sleep aids, strong pain medications (opioids), or muscle relaxants can cause severe drowsiness and life-threatening breathing problems.
  • Blood-thinning medicines: Combining sertraline with anticoagulants (such as warfarin) or antiplatelet medicines (such as aspirin or clopidogrel) may increase the risk of bruising and bleeding. 
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip

Certain foods and drinks may interact with this medicine:

  • Grapefruit and grapefruit juice: Grapefruit can slow down how your body processes alprazolam, raising the levels of the medicine in your blood and increasing the risk of severe side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

Yes

Therapeutic Class

[CENTRAL NERVOUS SYSTEM AGENTS]

FAQs

Alprax Plus Tablet is used to treat panic disorder.
Alprax Plus Tablet contains Alprazolam and Sertraline. Alprazolam is a benzodiazepine. It works by increasing the activity of a chemical messenger in the brain that produces a calming-effect. On the other hand, Sertraline is a selective serotonin reuptake inhibitor (SSRI), which increases the release of the serotonin hormone in the body that is responsible for improving mood, cognition and memory.
Yes. Alprax Plus Tablet may cause drowsiness, dizziness, and slower reaction times, especially when you first start treatment or after a dose increase. Avoid driving, operating machinery, or performing tasks requiring alertness until you know how the medicine affects you. Once you know how the medicine affects you, ask your doctor whether it is safe for you to drive.
Alprax Plus Tablet may also treat depression. However, please consult your doctor before taking this medicine for any indication.
Alprax Plus Tablet may cause erectile dysfunction in some patients. In general, this condition improves as the body adjusts to the medicine along the course of therapy. However, consult your doctor if the condition persists.
Alprax Plus Tablet may affect blood sugar levels. So, let your doctor know that you have diabetes before using Alprax Plus Tablet .
Alprax Plus Tablet should not be used along with antidepressants such as monoamine oxidase inhibitors (MAOI). You should wait for at least 14 days before taking Alprax Plus Tablet after stopping MAOI. So, it is necessary to let your doctor know about all the medicines you are taking before using Alprax Plus Tablet .
No, don’t increase your regular dose of Alprax Plus Tablet . Increasing the dose might not suit your condition and could lead to harmful complications. If you still feel anxious, consult your doctor. They will examine your situation and take necessary action.
Taking Alprax Plus Tablet can lead to weight gain or loss due to appetite changes. Depending on your individual response to the medication, you may feel more or less hungry than usual. Focus on a nutrient-dense diet and regular exercise to maintain a healthy weight.
It's important to complete the prescribed duration of treatment, even if symptoms improve. Stopping suddenly without finishing the full course may lead to the condition's recurrence and negative complications. If you have concerns, consult your doctor, who will assess your condition and provide guidance on whether to continue or discontinue treatment while minimizing potential side effects.
Store Alprax Plus Tablet by keeping it cool, dry, and out of sunlight. Keep it out of the reach of children. Regularly check the expiration date. When you need to dispose of the medicine, place it in a plastic bag and throw it away in the household trash. Remember, never flush the medicine down the toilet or sink to prevent harm to others and the environment.
The common side effects of the Alprax Plus Tablet are nausea (feeling sick), increased appetite, restlessness, drowsiness, dizziness, headache, constipation, dry mouth, jerks or uncoordinated movements, numbing or tingling sensation, vision problems, tinnitus (ringing in ears), ejaculation failure, fatigue (extreme tiredness). However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.
No, you must avoid alcohol completely. Combining alcohol with this medication can cause extreme drowsiness, severe dizziness, and dangerously slowed breathing. Talk to your doctor if you have questions about managing alcohol use.
Yes, the alprazolam component in this medicine has the potential to cause physical and psychological dependence, especially if used for a prolonged period. It is crucial to take it exactly as prescribed by your doctor. Talk to your doctor to understand how to use this medicine safely.
Taking this medicine during pregnancy is generally not recommended, as it may pose risks to the developing baby. If you are pregnant, planning to become pregnant, or are breastfeeding, talk to your doctor to weigh the risks and benefits of your treatment options.
Dry mouth is a common and usually harmless side effect. You can manage this by sipping water throughout the day, chewing sugar-free gum, or sucking on sugar-free hard candies. Talk to your doctor or pharmacist if the dry mouth becomes severe or persistent.
Take this medicine exactly as prescribed by your doctor. Depending on the formulation and your medical condition, it may be taken once daily or in divided doses. Taking it at the same time(s) each day helps maintain consistent medicine levels. Follow your doctor's prescribed dosing schedule and do not change it without medical advice.
Seek emergency medical help immediately if you experience severe difficulty breathing, loss of consciousness, seizures, signs of a severe allergic reaction, or thoughts of self-harm. In India, call 108 (where available) or your local emergency medical services while arranging urgent medical care.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.5760 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Pil.1657 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Alprazolam Alprazolam. 1982. [Accessed on 22 Apr. 2019]Check here
  4. Sertaline Sertaline. 2014. [Accessed on 23 Apr. 2019]Check here
  5. Alprazolam Alprazolam. [Accessed on 22 Apr. 2019]Check here
  6. Sertaline Sertaline. 2008. [Accessed on 23 Apr. 2019]Check here
  7. Fisekovic Saida and Loga-Zec Svjetlana. SERTRALINE AND ALPRAZOLAM IN THE TREATMENT OF PANIC DESORDER. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. May 2005. [Accessed on 25th January 2023]Check here

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - ALP0015

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