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  3. ALRUBICIN 50MG INJECTION 25ML

ALRUBICIN 50MG INJECTION 25ML, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

ALRUBICIN 50MG INJECTION is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer. It contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Thus, it treats cancers.

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Synonym :

EPIRUBICIN HYDROCHLORIDE

Composition :

EPIRUBICIN-50MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About ALRUBICIN 50MG INJECTION

ALRUBICIN 50MG INJECTION is an anti-cancer medicine that is used in conjunction with other drugs to treat breast cancer in people who have had tumor removal surgery. ALRUBICIN 50MG INJECTION is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast).

ALRUBICIN 50MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

ALRUBICIN 50MG INJECTION may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer ALRUBICIN 50MG INJECTION. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

ALRUBICIN 50MG INJECTION should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines, and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (eg, Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. ALRUBICIN 50MG INJECTION is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. ALRUBICIN 50MG INJECTION is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF.

Uses of ALRUBICIN 50MG INJECTION

Treatment of Breast Cancer

Directions for Use

A trained healthcare professional will administer ALRUBICIN 50MG INJECTION. Hence, do not self-administer.

Medicinal Benefits

ALRUBICIN 50MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. It is used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer.

How ALRUBICIN 50MG INJECTION Works

ALRUBICIN 50MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Storage

Store in a cool and dry place away from sunlight
Side effects of Alrubicin 50mg Injection 25ml
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Eat a healthy balanced diet.
  • Reduce stress with relaxation techniques such as yoga or meditation.
  • Keep track of your menstrual cycle any irregularities.
  • Have regular check ups to exclude other health problems.
  • Exercise but do not exercise to the extent of overheating.
  • Hydrate well, eat well (particularly iron and vitamins).
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.

What if I have taken an overdose of ALRUBICIN 50MG INJECTION

Since ALRUBICIN 50MG INJECTION is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of ALRUBICIN 50MG INJECTION may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Drug Warnings

ALRUBICIN 50MG INJECTION should be avoided if you are allergic to it. It is contraindicated in patients having a recent history of myocardial infarction (MI) or heart attack, patients with baseline neutrophil count < 1500 cells/mm3, severe arrhythmias, previous treatment with anthracyclines and severe hepatic dysfunction. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any medicines such as cardiotoxic drugs (e.g., Thalidomide, doxorubicin, Abiraterone, tamoxifen, letrozole), and cimetidine, as it can cause serious adverse effects. ALRUBICIN 50MG INJECTION is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. ALRUBICIN 50MG INJECTION is not recommended for children as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF. Do not stop receiving ALRUBICIN 50MG INJECTION without a doctor’s advice, as it can cause serious health conditions. ALRUBICIN 50MG INJECTION is known to cause severe life-threatening haematological reactions, tissue necrosis, cardiomyopathy, secondary acute myelogenous leukaemia, and severe myelosuppression in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

verifiedApollotooltip
EpirubicinZiprasidone
Critical
EpirubicinCeritinib
Severe

Drug-Drug Interactions

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EpirubicinZiprasidone
Critical
How does the drug interact with Alrubicin 50mg Injection 25ml:
Using ziprasidone together with Alrubicin 50mg Injection 25ml can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Ziprasidone with Alrubicin 50mg Injection 25ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinCeritinib
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Taking Ceritinib with Alrubicin 50mg Injection 25ml can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Although taking Ceritinib and Alrubicin 50mg Injection 25ml together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
EpirubicinMoxifloxacin
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Using Moxifloxacin together with Alrubicin 50mg Injection 25ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Moxifloxacin with Alrubicin 50mg Injection 25ml together can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heart rhythm, vomiting, dizziness, difficulty breathing, or irregular heartbeat call a doctor right away. Do not discontinue any medications without consulting a doctor.
EpirubicinNilotinib
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Coadministration of Alrubicin 50mg Injection 25ml and nilotinib can increase the risk of an irregular heart rhythm. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Alrubicin 50mg Injection 25ml and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
EpirubicinHaloperidol
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Co-administration of Alrubicin 50mg Injection 25ml and Haloperidol can affect the rhythm of the heart.

How to manage the interaction:
Co-administration of Alrubicin 50mg Injection 25ml and Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
EpirubicinHydroxychloroquine
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
The combined use of Alrubicin 50mg Injection 25ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Alrubicin 50mg Injection 25ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
EpirubicinBaricitinib
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Coadministration of baricitinib and Alrubicin 50mg Injection 25ml can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Alrubicin 50mg Injection 25ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without talking to a doctor.
EpirubicinGatifloxacin
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Taking Alrubicin 50mg Injection 25ml with Gatifloxacin can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Alrubicin 50mg Injection 25ml with Gatifloxacin together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EpirubicinInfliximab
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Combining Infliximab with Alrubicin 50mg Injection 25ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Taking Infliximab with Alrubicin 50mg Injection 25ml together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, contact a doctor right away. Do not stop using any medications without a doctor's advice.
EpirubicinTofacitinib
Severe
How does the drug interact with Alrubicin 50mg Injection 25ml:
Taking Tofacitinib with Alrubicin 50mg Injection 25ml may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Alrubicin 50mg Injection 25ml with Tofacitinib can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to call your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Try to eat more healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.
  • Doing meditation and yoga for some time is very effective in helping cancer patients maintain a healthy attitude and body.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

ALRUBICIN 50MG INJECTION Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

ALRUBICIN 50MG INJECTION is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving ALRUBICIN 50MG INJECTION. Use reliable methods of birth control while on treatment with ALRUBICIN 50MG INJECTION.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving ALRUBICIN 50MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Safe

ALRUBICIN 50MG INJECTION does not affect your ability to drive. However, drive only if you are alert.

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Liver

Caution

ALRUBICIN 50MG INJECTION should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

bannner image

Children

Unsafe

ALRUBICIN 50MG INJECTION is not recommended for use in children, as it is known to cause anthracycline-induced acute manifestations of cardiotoxicity and chronic CHF leading to serious side effects.

Have a query?

FAQs

ALRUBICIN 50MG INJECTION is used to treat Breast Cancer.

ALRUBICIN 50MG INJECTION contains Epirubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

ALRUBICIN 50MG INJECTION can disrupt a woman&amp;#039;s natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with ALRUBICIN 50MG INJECTION.

Yes, ALRUBICIN 50MG INJECTION is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.

ALRUBICIN 50MG INJECTION is effective in treating breast cancer by slowing or stopping the growth of cancer cells. It inhibits the topoisomerase II enzyme, interfering with DNA replication and destroying cancer cells. However, like all medications, it can have side effects and interact with other drugs, so it's essential to follow your doctor's instructions to maximize effectiveness and minimize side effects.

ALRUBICIN 50MG INJECTION is a chemotherapy medication that contains the active ingredient Epirubicin, a type of anthracycline topoisomerase inhibitor, used to treat breast cancer after tumor removal surgery.

The common side effects of ALRUBICIN 50MG INJECTION may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, diarrhoea, and pain at the injection site. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ALR0003

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:44 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.mayoclinic.org/drugs-supplements/epirubicin-intravenous-route/side-effects/drg-20063685?p=1
  2. https://reference.medscape.com/drug/epirubicin-342251
  3. https://medlineplus.gov/druginfo/meds/a603003.html#
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/050778s021lbl.pdf
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