HYDROXYCHLOROQUINE comes into the category of 'Antimalarials' mainly used to treat or prevent malaria. Malaria is a life-threatening disease that is spread by the bite of an infected 'Anopheles mosquito'. When an infected mosquito bites a healthy person, then it transmits the 'Plasmodium parasite' into the bloodstream, which after several days starts affecting the red blood cells & liver cells, rupturing them in the process. Usually, an infected person starts noticing the symptoms of malaria within 10 days to 4 weeks after the infection that include shaking chills, high fever, profuse sweating, headache, nausea, vomiting, abdominal pain, diarrhoea, anaemia, muscle pain, convulsions, coma, and bloody stools.
HYDROXYCHLOROQUINE contains Hydroxychloroquine as its active constituent that comes under the therapeutic class of 'quinolone medicines'. It works by killing the parasite and stops the formation of the nontoxic heme metabolite hemozoin by the parasite. In this way, the parasite gets died from its toxic by-products released during its metabolism of haemoglobin.
Take HYDROXYCHLOROQUINE exactly in the same manner as suggested by the doctor, at fixed intervals every day for best results. . Take it after a meal or a glass of milk to avoid stomach upset or as suggested by the doctor. The dosing strength of HYDROXYCHLOROQUINE may vary from person to person depending upon the medical condition and the severity of the infection. A person taking HYDROXYCHLOROQUINE may experience some unpleasant effects of HYDROXYCHLOROQUINE that include vomiting, nausea, hair loss & itchy skin. However, not every person notices these side effects, and even some side effects do not require medical attention. In case of side effects get worsen or do not go within a couple of days, it is best to consult with the doctor.
Before taking HYDROXYCHLOROQUINE, please inform your doctor if you have any allergy (against any chloroquine salt), or have medical disorders like vision changes or damage to your retina caused by an anti-malaria medication, heart disease, heart rhythm disorder, diabetes, a stomach disorder, liver or kidney disease, psoriasis, alcoholism, porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system), a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Consult with your doctor if you are a pregnant lady as it is not known that if this medicine affects an unborn baby or not. Even in pregnancy, if proper treatment is not provided at the right time, it may even increase the risk of miscarriage, stillbirth, premature delivery, and low birth weight. A breastfeeding woman should not take HYDROXYCHLOROQUINE as this medicine can pass in breast milk, so it is better to talk to your doctor.
HYDROXYCHLOROQUINE falls into a group of medicines known as antimalarials, that are indicated for treating or preventing malaria. HYDROXYCHLOROQUINE contains Hydroxychloroquine, which is quinoline medicine, works by preventing the formation of the nontoxic heme metabolite hemozoin by the parasite. Due to this, the parasite dies from its own toxic by-products released due to the metabolism of haemoglobin. HYDROXYCHLOROQUINE is also indicated for the treatment of rheumatoid arthritis and discoid or systemic lupus erythematosus. HYDROXYCHLOROQUINE is not effective against all strains of malaria.
Like all medications, HYDROXYCHLOROQUINE may cause some unpleasant side effects that include changes in the colour of your eye, blurring, sensitivity to light, skin rashes, itching, Stomach pain, feeling sick, being sick, diarrhoea, loss of appetite, headache, mood changes. Most of the side effects of chloroquine do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
HYDROXYCHLOROQUINE does not respond well against all strains of malaria, so consult with your doctor if you are not responding well to HYDROXYCHLOROQUINE. This medicine can affect heart health, especially if a person is taking medicines, including the antibiotic azithromycin. An individual must consult with the doctor if they are noticing fast or pounding heartbeats and sudden dizziness. This medicine cannot be used for a long duration as it may cause irreversible damage to the eye that could lead to vision problems. HYDROXYCHLOROQUINE cannot be used in persons who have heart disease, heart rhythm disorder, diabetes, a stomach disorder, an allergy to quinine, liver or kidney disease, psoriasis, alcoholism, porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system), a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency. Consult with your doctor if you are pregnant or breastfeeding as this medicine could only be used if prescribed by the doctor.
Drug-drug interactions: HYDROXYCHLOROQUINE should not be used with some medicine that can increase the risk of serious side effects that include tricyclic antidepressants (amitriptyline), antirheumatic medications (leflunomide), and narcotic analgesics (tramadol).
Drug-food interactions: Limit the consumption of grapefruit or grapefruit juice with HYDROXYCHLOROQUINE as it can significantly increase the blood levels.
Drug disease interactions: HYDROXYCHLOROQUINE cannot be used in patients with oculotoxicity, porphyria, arrhythmias, bone marrow suppression, ototoxicity, seizures, glucose-6-pd deficiency, hepatotoxicity, myasthenia gravis, psoriasis, diabetes, heart disease, and renal impairment.
A person should limit the consumption of alcohol as it may worsen the side effects.
HYDROXYCHLOROQUINE should be used with caution and can only be used in pregnancy if recommended by the doctor.
It is not safe to breastfeed while taking HYDROXYCHLOROQUINE as this medicine can pass into breast milk.
HYDROXYCHLOROQUINE may cause blurred vision, so one should avoid driving or doing any activity that needs mental alertness.
Chloroquine therapy is unlikely to cause liver injury in normal individuals but can trigger an acute worsening of porphyria in rare cases. Thus doctor's consultation is recommended if any interaction is experienced.
Chloroquine administration impairs kidney function in a few cases; thus, the doctor's consultation is required.
Certain diagnostic tests like “blood smear” can help in detecting malaria.
Malaria: It is a life-threatening disease caused by parasites that enter the body through the bite of a mosquito. This is a common disease in countries like Africa, South America, and Southern Asia. This disease usually occurs when an infected mosquito( infected with parasite 'Plasmodium', parasites are organisms that live in other living organisms for their survival) bites a healthy individual then this parasite gets transferred into the bloodstream and start growing and destroying the red blood cells of the body. There are four parasites responsible for causing malaria that include Plasmodium vivax, P. ovale, P. malaria, and P. falciparum. Generally, an infected person starts noticing the symptoms within 10 days to 4 weeks after the mosquito bite, which includes shaking chills that can range from moderate to high fever, profuse sweating, headache, nausea, vomiting, abdominal pain, diarrhoea, anaemia, muscle pain, convulsions, coma, and bloody stools.
If a person is taking any medicine for diarrhoea, then they should maintain at least a gap of 4 hours before or after taking HYDROXYCHLOROQUINE as this medicine can interact with diarrhoea medicine and prevent the body to absorb the drug fully.
It has been reported that taking HYDROXYCHLOROQUINE for a long time may cause irreversible damage to the retina of your eye which can even lead to vision loss, so take this medicine for the time suggested by the doctor.
This medicine can not be given to patients dealing with G6PD deficiency as it can increase the risk of hemolysis. Please consult your doctor before taking it.
No such effect has been reported yet. Always consult your doctor for the change of dose regimen or an alternative medicine if needed.
No, it does not affect any of these conditions. Patients should follow the advice of the doctor regarding its use.
The use of HYDROXYCHLOROQUINE is not allowed in persons who are already taking any antibiotic (azithromycin) as it may cause dangerous effects on the heart.