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compositionComposition:ITOLIZUMAB-25MG
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Alzumab 25mg Injection is used to treat psoriasis. It contains Itolizumab which works by reducing the synthesis of substances that cause inflammation. In some cases, this medicine may cause side effects such as pain and swelling at the injection site, fever, itching, dizziness, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ITOLIZUMAB-25MG

Manufacturer/Marketer :

Biocon Ltd

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Alzumab 25mg Injection

Alzumab 25mg Injection is a specialised medicine used to treat moderate-to-severe plaque psoriasis, an autoimmune condition that causes red, itchy, and scaly patches on the skin. It works by targeting specific pathways in the immune system to reduce inflammation and calm skin cell overproduction. Your doctor will prescribe this treatment when other standard therapies have not worked well enough.

This medicine is given as an injection or infusion at regular intervals, and maintaining a consistent schedule is highly important for achieving the best results. Since this medicine is administered by injection or intravenous infusion, food does not affect its administration. Staying well hydrated before your appointment may be recommended, unless your doctor advises otherwise. Combining this treatment with a healthy diet and lifestyle, such as keeping your skin well-moisturized and managing stress, can further help manage your symptoms.

While taking Alzumab 25mg Injection, you may experience mild side effects like itching, headaches, or slight pain where the medicine was injected. However, if you experience serious side effects such as a high fever, severe cough, or difficulty breathing, you must contact your doctor immediately. These symptoms could point to an infection, which requires urgent medical evaluation.

Before you start using Alzumab 25mg Injection, tell your doctor if you have a history of chronic infections, tuberculosis, or liver damage. Do not take this if you currently have an active, severe infection or if you have had a severe allergic reaction to this medicine or its ingredients in the past. Your safety is the priority, so a thorough medical check is necessary before your first dose.

This medicine can interact with other drugs that lower your immune system and with certain live vaccines, which should be avoided during treatment. It is also important to talk to your doctor if you drink alcohol regularly or smoke, as these can affect how your body responds to the treatment. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your healthcare provider to discuss the safety of this medication.

Uses of Alzumab 25mg Injection

Alzumab 25mg Injection is prescribed to help control inflammation and abnormal skin cell growth in autoimmune conditions. It is commonly used for the following conditions:

  • Moderate-to-severe plaque psoriasis: Alzumab 25mg Injection helps reduce the rapid buildup of skin cells and calms the underlying inflammation, which clears red, scaly patches on the body.

Key Benefits

Alzumab 25mg Injection helps control the underlying inflammation responsible for psoriasis, providing long-term symptom relief and improving skin health. The key benefits include:

  • Clears Psoriasis Plaques: Helps reduce the thickness, redness, and scaling of psoriasis plaques by targeting the underlying inflammatory process.
  • Reduces Itching and Discomfort: Provides long-term relief from persistent itching, skin tightness, and irritation, improving overall comfort.
  • Improves Quality of Life: Helps keep symptoms under control, making daily activities and movement more comfortable while reducing the frequency of flare-ups.
Side effects of Alzumab 25mg Injection
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Alzumab 25mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Alzumab 25mg Injection Works

Alzumab 25mg Injection contains itolizumab, a monoclonal antibody that acts as a targeted therapy to help control an overactive immune response. It works by binding specifically to a protein called CD6, which is found on the surface of T-cells (a type of white blood cell). CD6 normally interacts with another protein called activated leucocyte cell adhesion molecule (ALCAM or CD166) to promote T-cell activation and inflammation. By interfering with this CD6–ALCAM signalling pathway, Alzumab 25mg Injection helps reduce excessive immune activation. In autoimmune conditions such as psoriasis, this helps prevent the inflammation that causes skin cells to multiply too quickly. By binding to the CD6 protein, Alzumab 25mg Injection helps calm overactive T-cells without completely suppressing the immune system. This targeted approach slows the rapid production of skin cells and reduces skin inflammation, allowing the skin to heal naturally.
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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Alzumab 25mg Injection. Alcohol intake, along with Alzumab 25mg Injection, may cause increased dizziness.

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Pregnancy

Unsafe

Alzumab 25mg Injection is not recommended during pregnancy since it may have harmful effects on the developing baby. Your doctor will prescribe Alzumab 25mg Injection only if the benefit outweighs the risk.

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Breast Feeding

Caution

It is not known if Alzumab 25mg Injection passes into the breastmilk when used by breastfeeding mother. Your doctor will prescribe Alzumab 25mg Injection only if the benefit outweighs the risk.

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Driving

Unsafe

Alzumab 25mg Injection may make you feel dizzy. Do not drive or operate machinery if you experience dizziness.

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Liver

Caution

Please consult your doctor since Alzumab 25mg Injection should be used with caution in patients with liver impairment/liver disease. Dose adjustment may be needed in patients with liver impairment. However, Alzumab 25mg Injection is not recommended in patients with active liver diseases.

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Kidney

Caution

Please consult your doctor since Alzumab 25mg Injection should be used with caution in patients with kidney impairment/kidney disease. Dose adjustment may be required.

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Children

Unsafe

Alzumab 25mg Injection is not recommended in children and adolescents younger than 18 years of age.

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Heart

Caution

Alzumab 25mg Injection should be administered with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before receiving Alzumab 25mg Injection.

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Geriatrics

Caution

Alzumab 25mg Injection should be administered with caution in elderly patients due to an increased risk of side effects. Seek medical advice if you have any concerns.

What if I have taken an overdose of Alzumab 25mg Injection

An overdose is highly unlikely because a healthcare professional administers this medication. However, if you suspect an incorrect amount has been given, seek immediate medical attention or call your doctor.

Diet & Lifestyle Advise

  • Follow a Healthy Diet: Eat a balanced, anti-inflammatory diet rich in leafy green vegetables, berries, and omega-3 fatty acids (such as flaxseeds or oily fish) to support skin health.
  • Moisturise Regularly: Apply a gentle, fragrance-free moisturiser immediately after bathing to lock in moisture and help protect the skin barrier.
  • Avoid Smoking and Limit Alcohol: Do not smoke and limit alcohol consumption, as both can trigger psoriasis flare-ups and reduce the effectiveness of treatment.
  • Manage Stress: Practise stress-reduction techniques such as deep breathing, meditation, or gentle walking, as stress can worsen psoriasis symptoms and trigger flare-ups.
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How Soon It Starts Working

The time required for Alzumab 25mg Injection to start to work: The time required for Alzumab 25mg Injection to show its action is unknown. The time for which the effects of Alzumab 25mg Injection last: The effect of Alzumab 25mg Injection lasts for 15 hours.

What if you forget to take Alzumab 25mg Injection

Since this medicine is given under medical supervision, please contact your doctor or clinic immediately to reschedule your appointment if you miss a scheduled session.

Storage

•Store Alzumab 25mg Injection in a refrigerator at 2°C to 8°C. Do not freeze the medicine. Do not use it if it has been accidentally frozen. •Keep the vial or prefilled syringe in its original carton to protect it from light.

Drug Warnings

  • Inspect Before Use: Check the solution before each injection. It should be clear to slightly cloudy and colourless to pale yellow. Do not use it if you notice floating particles or significant discolouration.
  • Report Signs of Infection: Tell your doctor immediately if you develop symptoms of an infection, such as a cold, flu, fever, or open skin wounds, as your treatment may need to be delayed.
  • Avoid Live Vaccines: Do not receive live vaccines, such as the yellow fever or shingles vaccine, while using this medicine unless advised by your doctor.
  • Rotate Injection Sites: If you have been instructed to self-inject, rotate injection sites, such as the thigh or abdomen, to help reduce skin soreness and irritation.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact with this medicine and affect its safety or effectiveness.

  • Other immune-suppressing medicines: Combining Alzumab 25mg Injection with other biologics or immunosuppressive drugs can significantly increase your risk of developing serious infections.
  • Live vaccines: Taking this medicine alongside live vaccines may cause the vaccine to trigger an active infection because your immune defences are modified.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Alzumab 25mg Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[IMMUNOMODULATORS]

FAQs

Alzumab 25mg Injection contains Itolizumab, an immunomodulator. It reduces the synthesis of pro-inflammatory markers called cytokines. Thus, it helps in decreasing inflammation in various diseases like psoriasis, rheumatoid arthritis, and multiple sclerosis.
Alzumab 25mg Injection is currently being used to decrease the negative outcome of the cytokine storm in critically, severely and moderately ill COVID-19 patients.
Alzumab 25mg Injection is to be carefully administered with caution in patients under doctor's supervision only. The safety of Alzumab 25mg Injection is not yet evaluated in conditions like neutropenia (low levels of neutrophils), lymphopenia (low levels of lymphocytes), AIDS, tuberculosis, hepatitis B and C.
Even if there is no improvement after administering Alzumab 25mg Injection, your doctor may suggest an alternate course. Please note that Alzumab 25mg Injection does not reverse the damage caused due to coronavirus infection, but it will further prevent the inflammation of the lungs. It is also advised to medically examine for other lung and heart related dysfunctions even the patient suffers breathlessness after Alzumab 25mg Injection administration.
It is not recommended to get live attenuated vaccines while being treated with Alzumab 25mg Injection. This may lead to serious conditions. Please consult a doctor before you start Alzumab 25mg Injection if you are undergoing any vaccinations.
There is limited data on the safety of this medicine during pregnancy and breastfeeding. Talk to your doctor to carefully weigh the potential benefits against any risks to your baby.
Hair loss is not a commonly recognized side effect of this medicine. If you notice unusual hair thinning, talk to your doctor to check for other potential causes.
While there is no direct chemical interaction, alcohol can trigger psoriasis flare-ups and place extra strain on your liver. It is best to consult your doctor about safe alcohol limits.
Mild injection site reactions are common and usually go away on their own. Applying a cool compress can help soothe the skin. If the redness, swelling, or pain worsens, contact your doctor.
Yes, but you must keep it cool using a travel cooler bag with ice packs to maintain the temperature between 2°C to 8°C. Do not let the medication freeze, and talk to your doctor or pharmacist for travel tips.

Disclaimer

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Country of origin

India

Manufacturer/Marketer address

Nirmala Apartments,93, Jayprakash Road, Andheri (West),Mumbai - 400 058. India.
Other Info - AL34258
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