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compositionComposition:AMPHOTERICIN B-50MG
prescription
Prescription Medicine
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Ambi-V 50 mg Injection 1's is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-29

Return Policy :

Not Returnable

About Ambi-V 50 mg Injection 1's

Ambi-V 50 mg Injection 1's is a prescription injection used to treat serious, potentially life-threatening fungal infections throughout the body. It is also prescribed to treat certain severe parasitic infections when other options are not suitable.

Because this medication is given as an injection or slow infusion into a vein, it is typically given by a healthcare professional in a hospital or specialised clinic. The frequency of your treatment depends on your specific medical condition and how well your body responds to the therapy. Staying well-hydrated and maintaining a balanced diet are important lifestyle habits that can support your body's recovery during this therapy.

Some people may experience side effects during treatment, such as fever, shaking, chills, nausea, or changes in kidney function. It is highly important to consult your doctor immediately if you experience severe symptoms like extreme weakness, an irregular heartbeat, or difficulty breathing.

Talk to your doctor before starting this medicine if you have a history of kidney disease, liver damage, heart conditions, or low levels of potassium or magnesium. Do not take this if you have had a severe, life-threatening allergic reaction to this medicine or any of its ingredients in the past.

This medicine can interact with other drugs, especially those that can cause kidney damage, as well as certain water pills or steroids. Always tell your healthcare provider if you are pregnant, breastfeeding, or if you are caring for an elderly patient, as these groups require careful medical supervision during treatment.

Uses of Ambi-V 50 mg Injection 1's

Ambi-V 50 mg Injection 1's is used in the treatment of severe fungal infections. The detailed uses of Ambi-V 50 mg Injection 1's are as follows:

  • Severe fungal infections: This medicine is used to treat deep and potentially life-threatening fungal infections in organs like the lungs, blood, or brain. It works by stopping the growth and spread of the fungi causing the illness.
  • Visceral leishmaniasis: It is also used to treat a serious parasitic infection that affects internal organs, especially when other first-line treatments are not effective.

Key Benefits

Ambi-V 50 mg Injection 1's helps treat severe fungal infections that can affect different parts of the body, supporting recovery and improving overall health.

The following are the benefits of this medication:

  • Highly effective at reaching and clearing severe infections that other antifungal medicines might not be strong enough to cure.
  • Rapidly targets the cell walls of fungi, helping prevent the infection from spreading to other vital organs in your body.
  • This medication is a trusted choice for doctors managing critical, systemic infections, helping patients recover and regain their health.
Side effects of Ambi-v Inj 50mg
  • Eat potassium-rich foods like avocados, bananas, spinach, and potatoes.
  • Stay hydrated by drinking plenty of water.
  • Exercise regularly and maintain healthy weight.
  • Manage stress.
  • Prioritize 7-9 hours of sleep each night to help your body and mind recharge.
  • Avoid smoking and limit intake of caffeine.
  • Practice stress-reducing activities like meditation, yoga, or deep breathing to help calm your mind and body.
  • Avoid stimulants and illegal drugs.
  • Call your doctor if it worsens.
  • Muscle cramps can be treated with regular exercise or yoga, which includes mild stretching, which helps strengthen the lower body.
  • Warm baths and gentle massage of the affected parts can help relieve cramps.
  • Avoid strenuous activity and take frequent breaks, as rest is critical.
  • Intake of nutritious food can help strengthen body and mind. A trained nutritionist can help design a balanced diet for strengthening muscles.
  • Speak to your doctor if the pain lasts an extended period. Medical help can be practical in finding a cure for cramps.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

Directions for Use

  • Your doctor will determine the dosage and timing of Ambi-V 50 mg Injection 1's based on the severity of your infection. Typically, it is administered once daily.
  • Ambi-V 50 mg Injection 1's is administered by a healthcare professional in the hospital.
  • Do not self-administer it.

How Ambi-V 50 mg Injection 1's Works

Ambi-V 50 mg Injection 1's works by targeting the protective outer layer, or cell membrane, of the fungi causing your infection. It binds specifically to a component in this membrane called ergosterol. By doing this, the medicine creates physical holes or pores in the fungal cell wall. Once these holes are made, essential nutrients and minerals inside the fungal cell leak out. Without these vital components, the fungal cells cannot survive or multiply. This action effectively destroys the fungus, allowing your body's natural immune system to clear the rest of the infection.
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Alcohol

Caution

The interaction of Ambi-V 50 mg Injection 1's with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Ambi-V 50 mg Injection 1's is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether Ambi-V 50 mg Injection 1's is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking Ambi-V 50 mg Injection 1's as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Ambi-V 50 mg Injection 1's.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Ambi-V 50 mg Injection 1's.

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Children

Caution

Ambi-V 50 mg Injection 1's is not recommended for children below one month as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Ambi-V 50 mg Injection 1's. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Ambi-V 50 mg Injection 1's in elderly patients. Please consult your doctor.

What if I have taken an overdose of Ambi-V 50 mg Injection 1's

An overdose is highly unlikely when the medicine is given by a professional in a hospital. If you suspect an overdose or experience severe symptoms during or after your infusion, tell your medical team immediately or seek emergency medical care.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear fluids as advised by your doctor. Adequate hydration is crucial to help protect your kidneys while receiving this medicine.
  • Eat mineral-rich foods: Since this medicine can cause your body to lose potassium and magnesium, incorporate foods like bananas, leafy greens, avocados, and nuts into your diet if your doctor agrees.
  • Prioritise rest: Give your body ample time to heal by getting plenty of sleep and avoiding strenuous physical activities during your treatment course.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating smaller portions throughout the day can help you maintain your strength.
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Have a query?

How Soon It Starts Working

The time required for Ambi-V 50 mg Injection 1's to start to work: Ambi-V 50 mg Injection 1's ideally shows its action within 1 to 3 hours after administration The time for which the effects of Ambi-V 50 mg Injection 1's last: The duration of action for Ambi-V 50 mg Injection 1's is clinically unknown.

What if you forget to take Ambi-V 50 mg Injection 1's

Since this medication is given by a healthcare professional in a clinical setting, it is unlikely that you will miss a dose. However, if you miss an appointment for your injection, contact your healthcare provider or clinic immediately to reschedule your treatment.

Storage

•Unopened vials of Ambi-V 50 mg Injection 1's powder must be stored in a refrigerator at temperatures between 2°C to 8°C (36°F to 46°F).

Drug Warnings

  • Inspect the solution: Your healthcare provider will inspect the vial before use; the liquid must be free of unusual particles or cloudiness unless using a specific lipid version, which is naturally milky.
  • Expect blood tests: Prepare for regular blood and urine tests during your treatment so your doctor can monitor your kidney health, liver function, and mineral levels.
  • Manage infusion reactions: Let your nurse know if y ouexperience fever or chills during the injection; your doctor can give you preventive medicines like acetaminophen or antihistamines beforehand.
  • Monitor the injection site: Tell your nurse immediately if you feel any burning, pain, redness, or swelling where the needle is inserted.
  • Complete the full course: Even if you start feeling much better, do not skip or stop treatments early, as the infection could return.

Drug-Drug Interactions

verifiedApollotooltip
  • Other medicines that can cause kidney damage (e.g., certain antibiotics, cancer medicines, or pain relievers): Combining Ambi-V 50 mg Injection 1's with these medications can significantly increase the risk of kidney problems.
  • Water pills (diuretics) and steroids (e.g., furosemide, prednisone): Taking these alongside Ambi-V 50 mg Injection 1's can cause your blood potassium levels to drop dangerously low.
  • Heart medications (e.g., digitalis): Low potassium levels caused by Ambi-V 50 mg Injection 1's can increase the risk of toxic heart rhythms from digitalis.
Amphotericin bStreptozocin
Critical
Amphotericin bTenofovir alafenamide
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Ambi-v Inj 50mg:
Taking Ambi-v Inj 50mg and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Ambi-v Inj 50mg is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bTenofovir alafenamide
Severe
How does the drug interact with Ambi-v Inj 50mg:
Tenofovir alafenamide can cause kidney problems and taking it with amikacin, can enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Ambi-v Inj 50mg and Tenofovir alafenamide, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bDofetilide
Severe
How does the drug interact with Ambi-v Inj 50mg:
Using dofetilide together with Ambi-v Inj 50mg cholesteryl sulfate can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Ambi-v Inj 50mg and Dofetilide, but it can be taken if prescribed by a doctor. If you experience irregular heartbeat, feeling suddenly dizzy or lightheaded, fainting, a fast or strong heartbeat, feeling weak or tired, feeling sleepy or confused, muscle pain, and feeling sick to your stomach or throwing up. Do not stop using any medications without a doctor's advice.
Amphotericin bPimozide
Severe
How does the drug interact with Ambi-v Inj 50mg:
Pimozide used with Ambi-v Inj 50mg may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although taking Ambi-v Inj 50mg and Pimozide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Amphotericin bIoversol
Severe
How does the drug interact with Ambi-v Inj 50mg:
Coadministration of Ambi-v Inj 50mg and Ioversol may increase the risk of kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Ambi-v Inj 50mg and Ioversol, but it can be taken if prescribed by a doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Amphotericin bEverolimus
Severe
How does the drug interact with Ambi-v Inj 50mg:
Coadministration of Ambi-v Inj 50mg and Everolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Ambi-v Inj 50mg with Everolimus together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bSirolimus
Severe
How does the drug interact with Ambi-v Inj 50mg:
Coadministration of Sirolimus with Ambi-v Inj 50mg can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Ambi-v Inj 50mg and sirolimus together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bFoscarnet
Severe
How does the drug interact with Ambi-v Inj 50mg:
Using foscarnet together with Ambi-v Inj 50mg can cause serious side effects to the kidneys. Using these drugs together can also increase the risks of seizures (fits) and an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Ambi-v Inj 50mg and Foscarnet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: seizures, an irregular heart rhythm, feeling sick, swelling, sudden weight gain or loss, severe pain in your upper stomach that spreads, strong heartbeats, feeling dizzy, or chest pain. Do not discontinue any medications without consulting a doctor.
Amphotericin bTemsirolimus
Severe
How does the drug interact with Ambi-v Inj 50mg:
Coadministration of Ambi-v Inj 50mg and Temsirolimus may increase the risk of kidney problem.

How to manage the interaction:
Although taking Ambi-v Inj 50mg and Temsirolimus together can cause an interaction, it can be taken if a doctor has suggested it. If you experience any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting the doctor.
Amphotericin bAciclovir
Severe
How does the drug interact with Ambi-v Inj 50mg:
Coadministration of Aciclovir with Ambi-v Inj 50mg can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Aciclovir with Ambi-v Inj 50mg together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food or drink interactions have been found with Ambi-V 50 mg Injection 1's.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Ambi-V 50 mg Injection 1's is used to treat severe fungal infections like leishmaniasis.
Ambi-V 50 mg Injection 1's contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.
You are not recommended to take Ambi-V 50 mg Injection 1's with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Ambi-V 50 mg Injection 1's with other medicines.
Ambi-V 50 mg Injection 1's may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.
Yes, a test dose of Ambi-V 50 mg Injection 1's may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.
No. Ambi-V 50 mg Injection 1's is not effective against viral infections. It is an antifungal medicine that works by damaging fungal cell membranes and is used only for the treatment of severe fungal infections and certain parasitic infections such as leishmaniasis.
Ambi-V 50 mg Injection 1's is administered as an intravenous (IV) infusion by a healthcare professional. It should not be self-administered and is not available as a tablet or pill for treating severe systemic fungal infections because it is poorly absorbed from the stomach.
Ambi-V 50 mg Injection 1's is fungicidal in nature, it works by killing the infection-causing fungus.
Inform the doctor if you are allergic to any of the components in Ambi-V 50 mg Injection 1's or if you experience allergic reactions during treatment with Ambi-V 50 mg Injection 1's. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.
Ambi-V 50 mg Injection 1's is an antifungal medication used to treat severe fungal infections like leishmaniasis
Common side effects include fever, chills, nausea, vomiting, headache, and muscle cramps or pain. Fever and chills commonly occur during the infusion and can often be managed by slowing the infusion or giving additional medicines. Inform your doctor or nurse if these symptoms are severe or persistent.
This medicine can affect your kidneys and lower your body's levels of essential minerals like potassium. Regular blood tests allow your healthcare team to monitor your organ function and keep you safe. Talk to your doctor about how often you will need these tests.
This medicine is generally used during pregnancy only if the potential benefits outweigh the risks to the unborn baby. Your doctor will make this decision based on your specific medical situation. Talk to your doctor if you are pregnant or breastfeeding.
While kidney function often decreases during treatment, it usually returns to normal or improves after the medicine is stopped. Your healthcare team will monitor you closely to prevent severe damage. Talk to your doctor if you have concerns about your kidney health.
Some patients may feel dizzy, weak, or tired after receiving this medicine. It is highly recommended to have someone else drive you home, especially after your first few treatment sessions. Talk to your doctor or pharmacist about whether it is safe for you to drive.
Because of the risk of infusion reactions and the need for careful preparation, this medicine is almost always given in a hospital or specialised infusion clinic. In rare cases, home-care nurses may give it if appropriate monitoring is set up. Talk to your doctor to see what options are available for you.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7Th To 12Th Floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103.
Other Info - AMB0547
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