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  3. Ambisome Injection 1's

Ambisome Injection 1's, Pack of 1 INJECTION
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Ambisome Injection is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Synonym :

LIPOSOMAL AMPHOTERICIN B

Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ambisome Injection

Ambisome Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Ambisome Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Ambisome Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Ambisome Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Ambisome Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Ambisome Injection. Ambisome Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Ambisome Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Ambisome Injection

Treatment of Severe fungal infections

Directions for Use

Ambisome Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Ambisome Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Ambisome Injection damages fungal cell membranes and kills fungi. Ambisome Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

How Ambisome Injection Works

Ambisome Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Storage

Store in a cool and dry place away from sunlight
Side effects of Ambisome Injection
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Ambisome Injection

Since Ambisome Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Ambisome Injection. Ambisome Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Ambisome Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Ambisome Injection.

Drug-Drug Interactions

verifiedApollotooltip
Amphotericin bStreptozocin
Critical
Amphotericin bAmiodarone
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Ambisome Injection:
Taking Ambisome Injection and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Ambisome Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bAmiodarone
Severe
How does the drug interact with Ambisome Injection:
Coadministration of amiodarone together with Ambisome Injection may raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Even though Amiodarone and Ambisome Injection interact, they can be used if prescribed by a doctor. If you have heart issues or electrolyte imbalances, you may be at greater risk. If you experience unexpected dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, dizziness, nausea, or vomiting, or heart palpitations, get medical attention. Do not discontinue any medications without consulting a doctor.
Amphotericin bZiprasidone
Severe
How does the drug interact with Ambisome Injection:
Co-administration of Ziprasidone with Ambisome Injection may raise the chance of a significantly abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Ambisome Injection and Ziprasidone, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, or rapid or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, contact a doctor immediately. You may need regular monitoring of your electrolyte (magnesium, potassium) levels. Do not stop using any medications without talking to a doctor.
Amphotericin bDroperidol
Severe
How does the drug interact with Ambisome Injection:
Using droperidol together with Ambisome Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Ambisome Injection and Droperidol together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's conduction, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, heart palpitations, feeling weak, feeling sleepy, feeling confused, muscle pain, feeling nauseous or vomiting - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bIohexol
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Ambisome Injection and Iohexol may increase the risk of kidney problems.

How to manage the interaction:
Although taking Ambisome Injection and Iohexol together can cause an interaction, it can be taken if a doctor has suggested it. It's important to keep an eye on how much you pee. If you notice any changes, like peeing more or less than usual, nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bIoversol
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Ambisome Injection and Ioversol may increase the risk of kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Ambisome Injection and Ioversol, but it can be taken if prescribed by a doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Amphotericin bSirolimus
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Sirolimus with Ambisome Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Ambisome Injection and sirolimus together can result in an interaction, it can be taken if a doctor has prescribed it. Consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bTacrolimus
Severe
How does the drug interact with Ambisome Injection:
Taking tacrolimus with Ambisome Injection can increase the risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Ambisome Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Amphotericin bAciclovir
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Aciclovir with Ambisome Injection can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Aciclovir with Ambisome Injection together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.
Amphotericin bAdefovir dipivoxil
Severe
How does the drug interact with Ambisome Injection:
Combining Ambisome Injection with Adefovir dipivoxil can increase the risk of kidney damage.

How to manage the interaction:
Although taking Ambisome Injection and Adefovir dipivoxil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.

  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Ambisome Injection Substitute

Substitutes safety advice

  • AMPHOTIN 50MG INJECTION

    by Others

    ₹214.20per tablet

  • Amphotret 50 mg Injection 1's

    by Others

    ₹214.70per tablet

  • Ambilon 50 mg Injection 1's

    by Others

    ₹8003.20per tablet

  • Ambilip 50 mg Injection 1's

    by Others

    ₹6059.80per tablet

  • Amfocare 50 mg Injection 1's

    by Others

    ₹204.30per tablet

Product Substitutes

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Alcohol

Caution

The interaction of Ambisome Injection with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Ambisome Injection is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether Ambisome Injection is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking Ambisome Injection as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Ambisome Injection.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Ambisome Injection.

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Children

Caution

Ambisome Injection is not recommended for children below one month as the safety and effectiveness were not established.

FAQs

Ambisome Injection is used to treat severe fungal infections like leishmaniasis.

Ambisome Injection contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.

You are not recommended to take Ambisome Injection with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Ambisome Injection with other medicines.

Ambisome Injection may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.

Yes, a test dose of Ambisome Injection may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.

You are recommended to use Ambisome Injection for as long as your doctor has prescribed it. However, the usual treatment is for a minimum of 14 days. Please consult a doctor if you experience any difficulty while taking Ambisome Injection.

Ambisome Injection is not used to treat viral infections. Ambisome Injection is an antifungal that kills fungi and is used to treat severe fungal infections.

Ambisome Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis. It kills fungi by destroying the fungal outer cell membrane.

Ambisome Injection will be administered intravenously by a healthcare professional; do not self-administer.

Ambisome Injection is fungicidal in nature, it works by killing the infection-causing fungus.

Inform the doctor if you are allergic to any of the components in Ambisome Injection or if you experience allergic reactions during treatment with Ambisome Injection. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.

Ambisome Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis

Ambisome Injection may cause side effects like fever, chills, nausea, vomiting, headache, muscle cramps or pain. Most of these side effects of Ambisome Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - AMB0029

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Author Details

Doctor imageDoctor badge

Written By

Veda Maddala

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.5407.pdf
  2. https://www.drugs.com/mtm/amphotericin-b.html
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