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compositionComposition:AMPHOTERICIN B-50MG
prescription
Prescription Medicine
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AMPHOTIN 50MG INJECTION is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

United Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About AMPHOTIN 50MG INJECTION

AMPHOTIN 50MG INJECTION is a prescription injection used to treat serious, potentially life-threatening fungal infections throughout the body. It is also prescribed to treat certain severe parasitic infections when other options are not suitable.

Because this medication is given as an injection or slow infusion into a vein, it is typically given by a healthcare professional in a hospital or specialised clinic. The frequency of your treatment depends on your specific medical condition and how well your body responds to the therapy. Staying well-hydrated and maintaining a balanced diet are important lifestyle habits that can support your body's recovery during this therapy.

Some people may experience side effects during treatment, such as fever, shaking, chills, nausea, or changes in kidney function. It is highly important to consult your doctor immediately if you experience severe symptoms like extreme weakness, an irregular heartbeat, or difficulty breathing.

Talk to your doctor before starting this medicine if you have a history of kidney disease, liver damage, heart conditions, or low levels of potassium or magnesium. Do not take this if you have had a severe, life-threatening allergic reaction to this medicine or any of its ingredients in the past.

This medicine can interact with other drugs, especially those that can cause kidney damage, as well as certain water pills or steroids. Always tell your healthcare provider if you are pregnant, breastfeeding, or if you are caring for an elderly patient, as these groups require careful medical supervision during treatment.

Uses of AMPHOTIN 50MG INJECTION

AMPHOTIN 50MG INJECTION is used in the treatment of severe fungal infections. The detailed uses of AMPHOTIN 50MG INJECTION are as follows:

  • Severe fungal infections: This medicine is used to treat deep and potentially life-threatening fungal infections in organs like the lungs, blood, or brain. It works by stopping the growth and spread of the fungi causing the illness.
  • Visceral leishmaniasis: It is also used to treat a serious parasitic infection that affects internal organs, especially when other first-line treatments are not effective.

Key Benefits

AMPHOTIN 50MG INJECTION helps treat severe fungal infections that can affect different parts of the body, supporting recovery and improving overall health.

The following are the benefits of this medication:

  • Highly effective at reaching and clearing severe infections that other antifungal medicines might not be strong enough to cure.
  • Rapidly targets the cell walls of fungi, helping prevent the infection from spreading to other vital organs in your body.
  • This medication is a trusted choice for doctors managing critical, systemic infections, helping patients recover and regain their health.
Side effects of Amphotin 50mg Injection
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Your doctor will determine the dosage and timing of AMPHOTIN 50MG INJECTION based on the severity of your infection. Typically, it is administered once daily.
  • AMPHOTIN 50MG INJECTION is administered by a healthcare professional in the hospital.
  • Do not self-administer it.

How AMPHOTIN 50MG INJECTION Works

AMPHOTIN 50MG INJECTION works by targeting the protective outer layer, or cell membrane, of the fungi causing your infection. It binds specifically to a component in this membrane called ergosterol. By doing this, the medicine creates physical holes or pores in the fungal cell wall. Once these holes are made, essential nutrients and minerals inside the fungal cell leak out. Without these vital components, the fungal cells cannot survive or multiply. This action effectively destroys the fungus, allowing your body's natural immune system to clear the rest of the infection.
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Alcohol

Caution

The interaction of AMPHOTIN 50MG INJECTION with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

AMPHOTIN 50MG INJECTION is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether AMPHOTIN 50MG INJECTION is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking AMPHOTIN 50MG INJECTION as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving AMPHOTIN 50MG INJECTION.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving AMPHOTIN 50MG INJECTION.

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Children

Caution

AMPHOTIN 50MG INJECTION is not recommended for children below one month as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using AMPHOTIN 50MG INJECTION. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of AMPHOTIN 50MG INJECTION in elderly patients. Please consult your doctor.

What if I have taken an overdose of AMPHOTIN 50MG INJECTION

An overdose is highly unlikely when the medicine is given by a professional in a hospital. If you suspect an overdose or experience severe symptoms during or after your infusion, tell your medical team immediately or seek emergency medical care.

Diet & Lifestyle Advise

  • Stay well-hydrated: Drink plenty of water and clear fluids as advised by your doctor. Adequate hydration is crucial to help protect your kidneys while receiving this medicine.
  • Eat mineral-rich foods: Since this medicine can cause your body to lose potassium and magnesium, incorporate foods like bananas, leafy greens, avocados, and nuts into your diet if your doctor agrees.
  • Prioritise rest: Give your body ample time to heal by getting plenty of sleep and avoiding strenuous physical activities during your treatment course.
  • Eat small, frequent meals: If you experience nausea or a loss of appetite, eating smaller portions throughout the day can help you maintain your strength.
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How Soon It Starts Working

The time required for AMPHOTIN 50MG INJECTION to start to work: AMPHOTIN 50MG INJECTION ideally shows its action within 1 to 3 hours after administration The time for which the effects of AMPHOTIN 50MG INJECTION last: The duration of action for AMPHOTIN 50MG INJECTION is clinically unknown.

What if you forget to take AMPHOTIN 50MG INJECTION

Since this medication is given by a healthcare professional in a clinical setting, it is unlikely that you will miss a dose. However, if you miss an appointment for your injection, contact your healthcare provider or clinic immediately to reschedule your treatment.

Storage

•Unopened vials of AMPHOTIN 50MG INJECTION powder must be stored in a refrigerator at temperatures between 2°C to 8°C (36°F to 46°F).
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

  • Inspect the solution: Your healthcare provider will inspect the vial before use; the liquid must be free of unusual particles or cloudiness unless using a specific lipid version, which is naturally milky.
  • Expect blood tests: Prepare for regular blood and urine tests during your treatment so your doctor can monitor your kidney health, liver function, and mineral levels.
  • Manage infusion reactions: Let your nurse know if y ouexperience fever or chills during the injection; your doctor can give you preventive medicines like acetaminophen or antihistamines beforehand.
  • Monitor the injection site: Tell your nurse immediately if you feel any burning, pain, redness, or swelling where the needle is inserted.
  • Complete the full course: Even if you start feeling much better, do not skip or stop treatments early, as the infection could return.

Drug-Drug Interactions

verifiedApollotooltip
  • Other medicines that can cause kidney damage (e.g., certain antibiotics, cancer medicines, or pain relievers): Combining AMPHOTIN 50MG INJECTION with these medications can significantly increase the risk of kidney problems.
  • Water pills (diuretics) and steroids (e.g., furosemide, prednisone): Taking these alongside AMPHOTIN 50MG INJECTION can cause your blood potassium levels to drop dangerously low.
  • Heart medications (e.g., digitalis): Low potassium levels caused by AMPHOTIN 50MG INJECTION can increase the risk of toxic heart rhythms from digitalis.
Amphotericin bStreptozocin
Critical
Amphotericin bIopamidol
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Amphotin 50mg Injection:
Taking Amphotin 50mg Injection and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Amphotin 50mg Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bIopamidol
Severe
How does the drug interact with Amphotin 50mg Injection:
Coadministration of Amphotin 50mg Injection and Iopamidol may increase the risk of kidney problem.

How to manage the interaction:
Taking Amphotin 50mg Injection with Iopamidol together can result in an interaction, but it can be taken if a doctor has advised it. It's important to keep an eye on how much you pee. If you notice any changes like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bTacrolimus
Severe
How does the drug interact with Amphotin 50mg Injection:
Taking tacrolimus with Amphotin 50mg Injection can increase the risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Amphotin 50mg Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Amphotericin bIotalamic acid
Severe
How does the drug interact with Amphotin 50mg Injection:
Coadministration of Amphotin 50mg Injection and Iotalamic acid may decrease the excretion rate of Iothalamic acid which could result in a higher serum level.

How to manage the interaction:
Although there is a possible interaction between Amphotin 50mg Injection and Iotalamic acid, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
Amphotericin bDronedarone
Severe
How does the drug interact with Amphotin 50mg Injection:
Dronedarone used with Amphotin 50mg Injection may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although there is a possible interaction between Amphotin 50mg Injection and Dronedarone, you can take these medicines together if prescribed by a doctor. You should also notify a doctor if you suffer any of the following symptoms: weakness, weariness, sleepiness, disorientation, muscular pain, cramps, dizziness, nausea, or vomiting. Do not stop using any medications without talking to a doctor.
Amphotericin bIodamide
Severe
How does the drug interact with Amphotin 50mg Injection:
Coadministration of Amphotin 50mg Injection and Iodamide may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Amphotin 50mg Injection and Iodamide, you can take these medicines together if prescribed by a doctor. It's important to keep an eye on how much you pee. If you notice any changes, let the doctor know. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Amphotericin bArsenic trioxide
Severe
How does the drug interact with Amphotin 50mg Injection:
Using arsenic trioxide together with Amphotin 50mg Injection cholesteryl sulfate can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Co-administration of Amphotin 50mg Injection with Arsenic trioxide can result in an interaction, but it can be taken if a doctor has advised it. If you experience irregular heartbeat, feeling suddenly dizzy or lightheaded, fainting, a fast or strong heartbeat, feeling weak or tired, feeling sleepy or confused, muscle pain, or feeling sick to your stomach. Do not stop using any medications without talking to a doctor.
Amphotericin bEverolimus
Severe
How does the drug interact with Amphotin 50mg Injection:
Coadministration of Amphotin 50mg Injection and Everolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Amphotin 50mg Injection with Everolimus together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bHuman immunoglobulin
Severe
How does the drug interact with Amphotin 50mg Injection:
Taking Human immunoglobulin with Amphotin 50mg Injection, may raise the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Human immunoglobulin and Amphotin 50mg Injection, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
Amphotericin bFoscarnet
Severe
How does the drug interact with Amphotin 50mg Injection:
Using foscarnet together with Amphotin 50mg Injection can cause serious side effects to the kidneys. Using these drugs together can also increase the risks of seizures (fits) and an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Amphotin 50mg Injection and Foscarnet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: seizures, an irregular heart rhythm, feeling sick, swelling, sudden weight gain or loss, severe pain in your upper stomach that spreads, strong heartbeats, feeling dizzy, or chest pain. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food or drink interactions have been found with AMPHOTIN 50MG INJECTION.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

AMPHOTIN 50MG INJECTION is used to treat severe fungal infections like leishmaniasis.
AMPHOTIN 50MG INJECTION contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.
You are not recommended to take AMPHOTIN 50MG INJECTION with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking AMPHOTIN 50MG INJECTION with other medicines.
AMPHOTIN 50MG INJECTION may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.
Yes, a test dose of AMPHOTIN 50MG INJECTION may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.
No. AMPHOTIN 50MG INJECTION is not effective against viral infections. It is an antifungal medicine that works by damaging fungal cell membranes and is used only for the treatment of severe fungal infections and certain parasitic infections such as leishmaniasis.
AMPHOTIN 50MG INJECTION is administered as an intravenous (IV) infusion by a healthcare professional. It should not be self-administered and is not available as a tablet or pill for treating severe systemic fungal infections because it is poorly absorbed from the stomach.
AMPHOTIN 50MG INJECTION is fungicidal in nature, it works by killing the infection-causing fungus.
Inform the doctor if you are allergic to any of the components in AMPHOTIN 50MG INJECTION or if you experience allergic reactions during treatment with AMPHOTIN 50MG INJECTION. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.
AMPHOTIN 50MG INJECTION is an antifungal medication used to treat severe fungal infections like leishmaniasis
Common side effects include fever, chills, nausea, vomiting, headache, and muscle cramps or pain. Fever and chills commonly occur during the infusion and can often be managed by slowing the infusion or giving additional medicines. Inform your doctor or nurse if these symptoms are severe or persistent.
This medicine can affect your kidneys and lower your body's levels of essential minerals like potassium. Regular blood tests allow your healthcare team to monitor your organ function and keep you safe. Talk to your doctor about how often you will need these tests.
This medicine is generally used during pregnancy only if the potential benefits outweigh the risks to the unborn baby. Your doctor will make this decision based on your specific medical situation. Talk to your doctor if you are pregnant or breastfeeding.
While kidney function often decreases during treatment, it usually returns to normal or improves after the medicine is stopped. Your healthcare team will monitor you closely to prevent severe damage. Talk to your doctor if you have concerns about your kidney health.
Some patients may feel dizzy, weak, or tired after receiving this medicine. It is highly recommended to have someone else drive you home, especially after your first few treatment sessions. Talk to your doctor or pharmacist about whether it is safe for you to drive.
Because of the risk of infusion reactions and the need for careful preparation, this medicine is almost always given in a hospital or specialised infusion clinic. In rare cases, home-care nurses may give it if appropriate monitoring is set up. Talk to your doctor to see what options are available for you.

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Country of origin

INDIA

Manufacturer/Marketer address

FC/B-1 (Extn.), Mohan Co-operative Industrial Estate Mathura Road, New Delhi - 110 044.
Other Info - AMP0051
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