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compositionComposition:STREPTOMYCIN-1GM
prescription
Prescription Medicine
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Ambistryn S 1gm Injection is an antibiotic used to treat and prevent bacterial infections like tuberculosis (TB), pneumonia, influenza, plague and other infections. It contains Streptomycin, which kills bacteria and treats infection. It may cause common side effects such as vomiting, nausea, vertigo, skin rash, and fever.

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Written By Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

STREPTOMYCIN-1GM

Manufacturer/Marketer :

Abbott India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ambistryn S 1gm Injection

Ambistryn S 1gm Injection is a prescription antibiotic injection used to treat severe bacterial infections, including tuberculosis, plague, and tularemia. It works by stopping the growth of these harmful bacteria in your body. Your doctor will determine the exact schedule for your treatment based on the type of infection.

Because this medicine is injected directly into a muscle, it can be taken with or without food. To get the best results, it is vital to receive these injections consistently at the exact times your doctor schedules. Staying well-hydrated and eating balanced meals during your recovery will also support your body in fighting off the infection.

While using Ambistryn S 1gm Injection, you may experience mild side effects like soreness at the injection site or slight dizziness. However, you should consult your doctor immediately if you experience serious symptoms such as ringing in your ears, hearing loss, or a significant decrease in urination.

Talk to your doctor before starting this treatment if you have a history of kidney disease, hearing problems, or nerve disorders. Do not take this medicine if you have ever had a severe allergic reaction to similar antibiotics.

This injection can interact with certain other medications, including strong water pills and other antibiotics, which can increase the risk of side effects. Avoid alcohol while undergoing treatment to prevent unnecessary strain on your organs. If you are pregnant, breastfeeding, or elderly, make sure to consult your doctor before receiving this medicine.

Uses of Ambistryn S 1gm Injection

Here are the main bacterial infections where Ambistryn S 1gm Injection is used to eliminate bacteria and help control serious illness:

  • Tuberculosis: Helps clear active tuberculosis infections, typically when used alongside other prescribed medications to destroy the bacteria.
  • Plague: Treats this rare and severe bacterial infection by rapidly halting the multiplication of the bacteria.
  • Tularemia: Stops the spread of the bacteria responsible for rabbit fever, promoting a complete recovery.
  • Bacterial Endocarditis: Helps treat serious infections of the heart valves when combined with other specific antibiotics.

Key Benefits

Ambistryn S 1gm Injection provides several important benefits by controlling serious bacterial infections and supporting recovery:

  • Treats Serious Bacterial Infections: It effectively kills susceptible bacteria responsible for severe and potentially life-threatening infections.
  • Relieves Infection Symptoms: As the infection clears, it helps reduce symptoms such as fever, persistent cough, inflammation, and general weakness.
  • Prevents the Spread of Infection: Early treatment helps stop bacteria from spreading to other organs, reducing the risk of serious complications.
  • Supports Faster Recovery: By controlling the infection promptly, Ambistryn S 1gm Injection helps restore strength, improve overall health, and promote recovery when used as prescribed.
Side effects of Ambistryn S 1gm Injection
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Eosinophil levels can be lowered by eating fruits and vegetables, avoiding smoking, and consuming alcohol in moderation.
  • Several foods, such as ginger, garlic, pepper, turmeric, and honey, might boost immunity.
  • Avoid dairy products, including cheese, yoghurt, and milk.
  • Drink water and keep yourself hydrated.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Ambistryn S 1gm Injection will be administered by a healthcare professional.
  • Do not self-administer.

How Ambistryn S 1gm Injection Works

Ambistryn S 1gm Injection contains streotomycin, an aminoglycoside antibiotic that helps treat bacterial infections. Ambistryn S 1gm Injection works by binding to the protein-making machinery inside bacteria, preventing them from producing the essential proteins they need to grow, multiply, and survive. Without these proteins, the bacteria are unable to function properly and eventually die. Together, these actions help stop the spread of the infection, eliminate the bacteria, and allow your body's natural immune system to clear the remaining infection.
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Alcohol

Caution

Alcohol should not be taken along with Ambistryn S 1gm Injection, it might lead to excessive sleepiness, coughing and mucus formation.

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Pregnancy

Caution

Ambistryn S 1gm Injection should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Ambistryn S 1gm Injection.

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Breast Feeding

Caution

Ambistryn S 1gm Injection is excreted in breast milk. Inform the doctor if you are a breastfeeding mother. Ambistryn S 1gm Injection is given to breastfeeding mothers only if the doctor thinks the benefits outweigh the risks.

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Driving

Caution

Drive with caution if you have taken Ambistryn S 1gm Injection as it might cause dizziness and make driving difficult.

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Liver

Caution

Inform your doctor before receiving the Ambistryn S 1gm Injection if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Inform your doctor before receiving the Ambistryn S 1gm Injection if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Ambistryn S 1gm Injection should only be given to children if required. The dose should be monitored closely as an overdose to children may lead to unpleasant side effects.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Ambistryn S 1gm Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Ambistryn S 1gm Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Ambistryn S 1gm Injection

Because this medicine is typically injected by a healthcare professional, an overdose is highly unlikely. However, if you receive too much or experience severe breathing problems or extreme dizziness, seek emergency medical care immediately.

Diet & Lifestyle Advise

  • Increase your water intake: Drink at least 8 to 10 glasses of water daily to help your kidneys process and clear the medicine efficiently.
  • Eat a protein-rich diet: Include foods like poultry, fish, beans, and eggs to help your body rebuild tissues and recover from severe bacterial infections.
  • Avoid consuming alcohol: Refrain from drinking alcohol during your treatment to prevent extra strain on your kidneys and liver.
  • Get sufficient rest: Aim for 8 hours of sleep each night to give your immune system the energy it needs to fight off the illness.

Health Queries

I have been receiving Streptomycin injections for tuberculosis for the past month and have developed painful lumps at the injection site on my buttocks. Is this a normal side effect, and what is the recommended remedy or treatment for this?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

Developing painful lumps (induration) at the injection site is a relatively common reaction to repeated intramuscular Streptomycin injections. It usually happens when medicine accumulates in the muscle tissue. To manage this, use a warm compress: Apply it to the area for 15-20 minutes a few times daily to improve blood flow and help dissolve the lump. Rotate Sites: Ensure your healthcare provider rotates the injection sites (alternating buttocks or thighs). Pain Relief: Over-the-counter paracetamol can help ease the discomfort. Please inform your doctor or nurse. They can inspect the lumps to rule out infection and suggest alternative injection techniques if needed.

I am receiving Streptomycin injections three times a week for Category II bone tuberculosis. Is lower back and side pain a common side effect of this medication?

Chandrakanta Jena

Chandrakanta Jena

Pharm D

Lower back and side pain is not a common direct side effect of streptomycin. However, because streptomycin can occasionally affect the kidneys, this pain could sometimes indicate kidney irritation. More commonly, since you are being treated for bone tuberculosis, the pain may actually be related to the infection itself, especially if it affects your spine or surrounding tissues. Please do not worry, but do contact your doctor promptly. They can easily run a simple blood test to check your kidney function and evaluate your back to ensure your tuberculosis treatment is progressing safely and effectively.
health query

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How Soon It Starts Working

The time required for Ambistryn S 1gm Injection to start to work: The time required for Ambistryn S 1gm Injection to show its action is unknown. The time for which the effects of Ambistryn S 1gm Injection last: The duration of action for Ambistryn S 1gm Injection is unknown.

What if you forget to take Ambistryn S 1gm Injection

If you miss a scheduled injection, contact your doctor or healthcare provider right away to get instructions on when to receive your next dose. Do not take a double dose to make up for a missed one.

Storage

• Store the dry powder vials at controlled room temperature, between 20°C and 25°C (68°F to 77°F). • Keep the vials inside their original outer box to protect them from direct light.

Drug Warnings

  • Check the solution: Do not use the injection if the liquid looks cloudy, discoloured, or contains tiny floating particles.
  • Change injection spots: Always inject into a different area of your muscle each time to reduce pain and prevent hard lumps from forming.
  • Watch for ear symptoms: Notify your doctor immediately if you notice even mild ringing in your ears, as this can be an early sign of hearing damage.
  • Keep your medical appointments: Attend all scheduled blood tests so your doctor can regularly check how well your kidneys are working.
  • Finish the entire course: Always complete the full treatment course prescribed by your doctor, even if your symptoms disappear early.

Drug-Drug Interactions

verifiedApollotooltip

Here are the medicines that may interact with Ambistryn S 1gm Injection and increase the risk of serious side effects:

  • Other Aminoglycoside Antibiotics: Using Ambistryn S 1gm Injection with other aminoglycoside antibiotics may increase the risk of kidney damage and permanent hearing loss.
  • Kidney- or Ear-Damaging Medicines: Certain chemotherapy medicines and loop diuretics (such as furosemide) may increase the risk of kidney injury or hearing problems when used with Ambistryn S 1gm Injection.
  • Muscle Relaxants: Ambistryn S 1gm Injection can enhance the effects of muscle relaxants, increasing the risk of muscle weakness and breathing difficulties.
StreptomycinCidofovir
Critical
StreptomycinMagnesium sulfate
Severe

Drug-Drug Interactions

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StreptomycinCidofovir
Critical
How does the drug interact with Ambistryn S 1gm Injection:
Using cidofovir with Ambistryn S 1gm Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Ambistryn S 1gm Injection with Cidofovir is not recommended, please consult your doctor before taking it. If you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
StreptomycinMagnesium sulfate
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Taking Magnesium sulfate with Ambistryn S 1gm Injection can increase the risk of muscle weakness.

How to manage the interaction:
Although taking Magnesium sulfate and Ambistryn S 1gm Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience symptoms such as muscle weakness and shortness of breath, chest pain or tightness, excessive sweating, body aches, or muscle stiffness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
StreptomycinTorasemide
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Taking Torasemide together with Ambistryn S 1gm Injection may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Ambistryn S 1gm Injection and torasemide together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as blurred vision, dry mouth, dry skin, frequent urination, nausea, and stomach pain, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
StreptomycinPolymyxin b
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Using Polymyxin b together with Ambistryn S 1gm Injection can increase the risk or severity of developing hearing loss, breathing problems, and kidney problems.

How to manage the interaction:
Although taking polymyxin B and Ambistryn S 1gm Injection together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, a decrease in hunger, increased or decreased urine, weight gain or loss that occurs suddenly, fluid retention, swelling, difficulty breathing, bone pain, muscle pain, fatigue, weakness, dizziness, confusion, and irregular heartbeat, hearing loss, ringing in the ears, vertigo, consult a doctor. Do not discontinue any medication without consulting a doctor.
StreptomycinAdefovir dipivoxil
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Using Adefovir dipivoxil together with Ambistryn S 1gm Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Ambistryn S 1gm Injection with Adefovir dipivoxil is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, irregular heart rhythm. Do not discontinue any medication without consulting a doctor.
StreptomycinMannitol
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Taking Ambistryn S 1gm Injection with Mannitol can increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Ambistryn S 1gm Injection with Mannitol together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, increased or decreased urination, or swelling, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
StreptomycinTubocurarine
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Co-administration of Ambistryn S 1gm Injection with Tubocurarine may increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Ambistryn S 1gm Injection and Tubocurarine, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or increased heart rate, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
StreptomycinCisatracurium
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Co-administration of Ambistryn S 1gm Injection with Cisatracurium may increase the risk or severity of side effects like decreased breathing rate, irregular heart rhythms, or problems with movement and memory.

How to manage the interaction:
Co-administration of Ambistryn S 1gm Injection with Cisatracurium can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
StreptomycinHuman immunoglobulin
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Co-administration of Human immunoglobulin with Ambistryn S 1gm Injection can increase the risk or severity of kidney problems.

How to manage the interaction:
Co-administration of Human immunoglobulin with Ambistryn S 1gm Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
StreptomycinRocuronium bromide
Severe
How does the drug interact with Ambistryn S 1gm Injection:
Coadministration of Rocuronium bromide with Ambistryn S 1gm Injection may increase the risk or severity of developing hearing loss, breathing problems, and kidney problems.

How to manage the interaction:
There may be a possibility of interaction between Rocuronium bromide and Ambistryn S 1gm Injection, but it can be taken if prescribed by a doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, swelling, increased or decreased urination, body aches, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Ambistryn S 1gm Injection when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- BACTERIALS]

FAQs

No, you must complete the entire course of treatment exactly as prescribed to ensure the infection is completely cleared and does not return.
It can affect your inner ear, which may lead to temporary or permanent hearing loss or ringing in your ears. Your doctor will monitor your hearing closely.
It is best to avoid alcohol because it can dehydrate your body and increase the risk of side effects like dizziness or strain on your kidneys.
This medicine is generally not recommended during pregnancy because it can cause hearing damage to the unborn baby.
Dizziness or loss of balance can be a serious side effect affecting your inner ear. Sit down safely and contact your doctor right away.
No, this medicine does not absorb well through the stomach and must be injected into a muscle to treat systemic infections effectively.
Ambistryn S 1gm Injection is administered by a trained healthcare professional, usually as an intramuscular (deep muscle) injection. In some situations, it may also be given intravenously (into a vein), depending on your condition and your doctor's recommendation. The dose and route are determined based on your age, weight, kidney function, and the type and severity of the infection.
Before starting treatment, your doctor may perform hearing (audiometry) and kidney function tests to establish a baseline. During treatment, regular blood tests (including kidney function and electrolyte levels such as potassium, calcium, and magnesium) and hearing tests may be performed to detect side effects early and ensure the medicine remains safe and effective.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Streptomycin Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 064210S009Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Mitchell Waters, Prasanna Tadi. Streptomycin. NIH National Library of Medicine. National Centre for Biotechnology Information. Statpearls [Internet]. July 2022. [Accessed on 7th September 2022]Check here
  4. NCPC International Corp. Streptomycin. [Revised in January 2018] [Accessed on 7th September 2022]Check here
  5. Chaves RG, Lamounier JA Breastfeeding and maternal medications. J Pediatr (Rio J). 2004;80(5 Suppl):S189-98Check here
  6. Taj Pharmaceuticals Limited. Streptomycin Injection. [Accessed on 7th September 2022]Check here

Country of origin

India

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - AMB0004
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